A5004655678- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Aortic aneurysm repair treatments
- Anatomy and Medical Technology
- Adipose Tissue and Metabolism
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- 3D Printing in Biomedical Research
- Circadian rhythm and melatonin
- Ovarian function and disorders
- Sirtuins and Resveratrol in Medicine
- Polymer Surface Interaction Studies
- Collagen: Extraction and Characterization
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Anesthesia and Pain Management
- Tendon Structure and Treatment
Xijing Hospital
2016-2025
Air Force Medical University
2016-2025
Kunming Medical University
2025
Kunming Children's Hospital
2025
State Key Laboratory of Chemical Engineering
2022-2025
Zhejiang University
2022-2025
Fujian Medical University
2012-2025
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
Ningxia Medical University
2023-2024
Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, unstable adhesion interfaces severely limited application suture-free high-quality healing. In this work, by controlling the interfacial distribution of free -COOH groups cationic-π structures on both sides hydrogels, a series PZBA-EGCG-ALC with varying degrees asymmetric properties are successfully prepared using simple...
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent its strong antioxidative activity. However, roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown. Since SIRT1 Nrf2 are pivotal regulators mellitus patients suffering from injury, we hypothesized that HKL ameliorates via the SIRT1-Nrf2 signaling pathway....
Aging is accompanied with unfavorable geometric and functional changes in the heart involving dysregulation of Akt autophagy. This study examined impact Akt2 ablation on life span cardiac aging as well mechanisms involved a focus autophagy mitochondrial integrity. Cardiac geometry, contractile, intracellular Ca
Diabetes mellitus (DM) increases myocardial oxidative stress and endoplasmic reticulum (ER) stress. Melatonin confers cardioprotective effect by suppressing damage. However, the mechanism of melatonin on ischemia-reperfusion (MI/R) injury in type 2 diabetic state are still unknown. In this study, we developed high-fat diet-fed streptozotocin (HFD-STZ) rat, a well-known model, to evaluate MI/R with focus silent information regulator 1 (SIRT1) signaling, stress, PERK/eIF2α/ATF4-mediated ER...
The objective of this study was to evaluate the safety and efficacy surgical versus transcatheter approach correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial.pmVSD is common congenital heart disease children. Surgical closure pmVSD well-established therapy but requires open-heart surgery with cardiopulmonary bypass. Although associated significant incidence complete atrioventricular block, it may provide less invasive...
Background/Aims: As a vasodilatory drug used to treat angina, nicorandil has been shown induce an infarct-limiting effect in various experimental animal models of myocardial ischemia-reperfusion (IR). There are multiple mechanisms causing the IR injury, among which, endoplasmic reticulum (ER) stress and ER stress-initiated apoptosis implicated play important role. However, whether is involved nicorandil-induced cardioprotection unknown. Methods: Post-ischemic functional recovery, lactate...
Abstract Melatonin confers profound protective effect against myocardial ischemia–reperfusion injury ( MI / RI ). Activation of N otch1/ H airy and enhancer split 1 es1) signaling also ameliorates . We hypothesize that melatonin attenuates ‐induced oxidative damage by activating es1 pathway with phosphatase tensin homolog deleted on chromosome 10 P ten)/ A kt acting as the downstream in a membrane receptor‐dependent manner. Male S prague D awley rats were treated (10 mg/kg/day) for 4 wk then...
Significance Many surgeries require surgical mesh to be attached firmly at target areas strengthen tissues, support organs, or repair wounds. Common methods of attachment include sutures, staples, and spiral tacks, but they damage tissues prolong surgeries. Adhesion has been considered a promising alternative method attach meshes existing approaches adhesion are too weak for most applications. Here, we develop composites hydrogels that can adhere stably. We demonstrate the applications...
Sepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin cleaved product fibronectin type III domain-containing protein 5 (FNDC5) that protects heart from ischemia/reperfusion injury through upregulation mitochondrial ubiquitin ligase (MITOL). Gasdermin D (GSDMD)-dependent pyroptosis plays pivotal role by regulating homeostasis. whether irisin can regulate MITOL to...
There is a continuing need for artificial bone substitutes repair and reconstruction, Magnesium phosphate cement (MPC) has exceptional degradable properties exhibits promising biocompatibility. However, its mechanical strength needs improved low osteo-inductive potential limits therapeutic application in regeneration. We functionally modified MPC by using polymeric carboxymethyl chitosan-sodium alginate (CMCS/SA) gel network. This had the advantages of: compressive strength, ease of...
Bovine pericardium (BP) has been used as leaflets of prosthetic heart valves. The are sutured on metallic stents and can survive 400 million flaps (~10-year life span), unaffected by the suture holes. This flaw-insensitive fatigue resistance is unmatched synthetic leaflets. We show that endurance strength BP under cyclic stretch insensitive to cuts long 1 centimeter, about two orders magnitude longer than a thermoplastic polyurethane (TPU). results from high collagen fibers soft matrix...
Melatonin, a circadian molecule secreted by the pineal gland, confers protective role against cardiac hypertrophy induced hyperthyroidism, chronic hypoxia, and isoproterenol. However, its pressure overload-induced underlying mechanisms remains elusive. In this study, we investigated pharmacological effects of melatonin on pathological transverse aortic constriction (TAC). Male C57BL/6 mice underwent TAC or sham surgery at day 0 were then treated with (20 mg/kg/day, via drinking water) for 4...
Abstract Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, biological cardiac-derived CTRP9 remains unclear. We hypothesize responds ischemia/reperfusion (MI/R) injury as cardiokine. explored MI/R via genetic manipulation CTRP9-knockout (CTRP9-KO) animal model. Inhibition exacerbated, whereas its overexpression...
Myocardial ischemia/reperfusion (MI/R) injury imposes devastating cardiovascular sequelae in particular cardiac dysfunction as a result of restored blood flow. However, the mechanism behind MI/R remains elusive. Mitochondrial ubiquitin ligase (MITOL/MARCH5) is localized at mitochondria-ER contact site and may be activated response to variety pathophysiological processes, such apoptosis, mitochondrial injury, ER stress, hypoxia, reactive oxygen species (ROS) generation. Irisin cleaved product...
Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM). However, the mechanisms underlying DCM-induced cardiac injury remain unclear. Recently, role cyclic GMP-AMP synthase/stimulator interferon gene (cGAS/STING) signaling and pyroptosis in DCM has been investigated. Based on our previous results, this study was designed to examine impact irisin, mitochondrial ubiquitin ligase (MITOL/MARCH5), cGAS/STING dysfunction effect gasdermin D (GSDMD)-dependent pyroptosis....
Abstract From degeneration causing intervertebral disc issues to trauma‐induced meniscus tears, diverse factors can injure the different types of cartilage. This review highlights adhesives as a promising and rapidly implemented repair strategy. Compared traditional techniques such sutures wires, offer several advantages. Importantly, they seamlessly connect with injured tissue, deliver bioactive substances directly site, potentially alleviate secondary problems like inflammation or...