A5102890903- Tendon Structure and Treatment
- Alzheimer's disease research and treatments
- Electrospun Nanofibers in Biomedical Applications
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Planarian Biology and Electrostimulation
- Dementia and Cognitive Impairment Research
- Cellular Mechanics and Interactions
- Neuroscience and Neuropharmacology Research
- Exercise and Physiological Responses
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Facial Rejuvenation and Surgery Techniques
- Kruppel-like factors research
- Orthopedic Surgery and Rehabilitation
- Connective tissue disorders research
- Laser Applications in Dentistry and Medicine
- Nerve injury and regeneration
- Collagen: Extraction and Characterization
Zhejiang University
2021-2025
First Affiliated Hospital Zhejiang University
2023-2025
Xiangya Hospital Central South University
2021-2024
Central South University
2020-2024
Shanghai Jiao Tong University
2017-2023
Shanghai Ninth People's Hospital
2019-2023
National Engineering Research Center for Nanotechnology
2019
Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, unstable adhesion interfaces severely limited application suture-free high-quality healing. In this work, by controlling the interfacial distribution of free -COOH groups cationic-π structures on both sides hydrogels, a series PZBA-EGCG-ALC with varying degrees asymmetric properties are successfully prepared using simple...
Abstract Background Peritendinous adhesion is among the common complications after tendon injury. Numerous studies have been carried out to prevent its formation, including modifications of surgical procedures, postoperative cares, application medicines, etc. This study dynamically monitored fluctuations inflammation, state oxidative stress, and histopathologic changes around injured provide theoretical basis for further exploration in mechanisms peritendinous formation. Methods Eighteen...
Keloids are benign skin tumors with a high recurrence rate following surgical excision. Abnormal intracellular signaling is one of the key mechanisms involved in its pathogenesis. Over‑activated phosphoinositide 3‑kinase/RAC‑alpha serine/threonine‑protein kinase/mammalian target rapamycin (PI3K/Akt/mTOR) pathway and overproduction histone deacetylases 2 (HDAC2) have also been observed keloid fibroblasts (KFs). The present study aimed to explore possibility reversing KF pathological phenotype...
Abstract TGFβ1 signaling is a critical driver of collagen accumulation in pulmonary fibrotic diseases and well-characterized regulator cancer associated fibroblasts (CAF) activation lung cancer. Myofibroblasts induced by other factors are key players the pathogenesis fibrosis tumor. Tremendous attention has been gained to targeting myofibroblasts order inhibit progression myofibroblast-induced tumor metastasis. Here we determined therapeutic efficacy simultaneously PI3K HDAC pathways CAF...
Abstract Electrospun membranes with biomimetic fibrous structures and high specific surfaces benefit cell proliferation tissue regeneration but are prone to cause chronic inflammation foreign body response (FBR). To solve these problems, we herein report an approach functionalize electrospun antibacterial anti-inflammatory components modulate inflammatory responses improve implantation outcomes. Specifically, polylactic acid (PLA)/gelatin (Gel) fibers were grafted chitosan (CS) ibuprofen...
Abstract Herbal extracts including asiatic acid (AA) have become popular candidates of anti‐photoaging agents due to their anti‐inflammatory and antioxidant properties minimal side effect. Nevertheless, low bioavailability poor solubility limits practical application. In this study, a highly bioavailable form AA called AAGS (compounded by glucosamine) was investigated for its effect using both in vitro vivo models along with UVB irradiation. The results showed that alleviated UVB‐induced...
Shank3 is a postsynaptic scaffolding protein of excitatory synapses. Mutations or variations SHANK3 are associated with various psychiatric and neurological disorders. We set to determine its normal expression pattern in the human brain, change, if any, age Alzheimer’s disease (AD)-type β-amyloid (Aβ) Tau pathogenesis. In general, immunoreactivity (IR) exhibited largely neuropil differential laminar/regional distribution across brain regions. youth adults, subsets pyramidal/multipolar...
Amyloid plaques and neurofibrillary tangles (NFT) are hallmark lesions of Alzheimer's disease (AD) related to β-amyloid (Aβ) deposition intraneuronal phosphorylated-tau (pTau) accumulation. Sortilin C-terminal fragments (shortened as "sorfra") can deposit senile plaque-like within AD brains. The course pattern sorfra plaque formation relative Aβ pTau pathogenesis remains unknown. In the present study cerebral subcortical brain regions in postmortem human brains (n=46) from aged subjects were...
Extracellular β-amyloid (Aβ) deposition and intraneuronal phosphorylated-tau (pTau) accumulation are the hallmark lesions of Alzheimer’s disease (AD). Recently, “sorfra” plaques, named for extracellular sor tilin c-terminal fra gments, reported as a new AD-related proteopathy, which develop in human cerebrum resembling spatiotemporal trajectory tauopathy. Here, we identified sortilin aggregation change related to development granulovacuolar degeneration (GVD), tauopathy, sorfra plaques...
Background:Fibroblast activation protein (FAP) has shown high expression in inflammatory responses and fibrosis. Hypothesis:We speculated that FAP could serve as a diagnostic monitoring target the tendon healing process. Methods:A total of 72 Sprague-Dawley rats were randomly divided into crush group half-partial laceration group. Four each injected with radiotracers weekly for 4 weeks after surgery, aluminum fluoride–labeled 1,4,7-triazacyclononane-N,N′,N″-triacetic acid–conjugated...
Our previous work demonstrated the tendon-derived extracellular matrix (ECM) extracts as vital niches to specifically direct mesenchymal stem cells towards tenogenic differentiation. This study aims further define effective ECM molecules capable of teno-lineage induction on human adipose-derived (hASCs) and test their function for tendon engineering. By detecting teno-markers expression levels in hASCs exposed various substrate coatings, collagen I (COL1) fibromodulin (FMOD) were identified...
Approximately 10% of patients with plantar fasciitis experience persistent and often severe symptoms, though little is known about its etiology. The goal this study was to employ an objective, simple, economical approach measure the change in length windlass assess efficiency a specified therapy protocol applied over one-month period. Age, weight, normal foot type, gender were employed as matching factors matched design. Fifty individuals diagnosed unilateral equal number healthy volunteers...
Schwann cells (SCs) are myelinating of the peripheral nervous system, playing a crucial role in nerve regeneration. Nanosecond Pulse Electric Field (nsPEF) is an emerging method applicable electrical stimulation that has been demonstrated to be effective stimulating cell proliferation and other biological processes. Aiming assess whether SCs undergo significant changes under nsPEF help explore potential for new regeneration methods, cultured RSC96 were subjected at 5 kV 10 kV, followed by...
Abstract Topography modified cell behavior remains less explored in diseased cells. This study investigated the reversing effect on pathological phenotype of keloid fibroblasts via culturing cells a parallel microgrooved surface. The results showed that this particular topography with 3 μm groove depth and 10 width could significantly elongate align cultured reduced (nucleus) area increased body aspect ratio major axis ( p < 0.05). Importantly, elongated gradually lost their fibrotic...
Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described the original literature defining this disease. These could be both axonal dendritic origin, while dystrophy relative to plaque formation has been more extensively studied. Here, we demonstrate an early occurrence of hippocampal CA1 subicular...