A5102019240- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Alzheimer's disease research and treatments
- Analytical Chemistry and Chromatography
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Interaction Studies and Fluorescence Analysis
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Chromatography in Natural Products
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photosynthetic Processes and Mechanisms
- Dementia and Cognitive Impairment Research
- Regulation of Appetite and Obesity
- Plant Gene Expression Analysis
- Single-cell and spatial transcriptomics
- Advanced Drug Delivery Systems
- HER2/EGFR in Cancer Research
- Wood and Agarwood Research
- Cholinesterase and Neurodegenerative Diseases
- Infant Nutrition and Health
- Forest Ecology and Biodiversity Studies
Research Institute of Tropical Forestry
2022-2025
Central South University
2019-2025
Zhejiang University
2015-2025
Chinese Academy of Forestry
2022-2025
State Forestry and Grassland Administration
2025
South China Normal University
2017-2020
State Key Laboratory of Chemical Engineering
2013-2016
The objective of this study is to explore the specific roles a crucial N6-methyladenosine (m6A) methyltransferase, methyltransferase-like 14 (METTL14), in fibroblast-like synoviocytes (FLSs) activation rheumatoid arthritis (RA). RA rat model was induced by administering intraperitoneally collagen antibody alcohol. Primary were isolated from joint synovium tissues rats. shRNA transfection tools used downregulate METTL14 expression vivo and vitro. injury shown hematoxylin eosin (HE) staining....
α-synuclein (α-syn) pathologies are central to the development of synucleinopathies including Parkinson's disease (PD). Positron emission tomography (PET) imaging α-syn is one strategy facilitate diagnosis, understanding, and treatment synucleinopathies, but has been restricted by lack specific PET probes. In this work, we identified 2,6-disubstituted imidazo[2,1-b][1,3,4]thiadiazole (ITA) as a new α-syn-binding scaffold. Through autoradiography studies, discovered an iodinated lead compound...
Aging increases the risk for Alzheimer's disease (AD), driving pathological changes like amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in prefrontal cortex (PFC). We present first subcellular-resolution spatial transcriptome atlas of human (PFC), generated with Stereo-seq from six male AD cases at varying neuropathological stages age-matched controls. Our analyses revealed distinct transcriptional alterations across PFC layers, highlighted disruptions laminar...
The abundance of phenolic compounds (including anthocyanins) in leaves is associated with photosynthetic performance, but the regulatory mechanism unclear. Schima superba Gardn. et Champ. and Cryptocarya concinna Hance., which exhibit distinct anthocyanin accumulation patterns, are dominant tree species early- late-successional stages, respectively, subtropical forests China. RNA-seq analyses concentrations, antioxidant capacity characteristics were performed on young mature these two under...
Continuous capture with affinity chromatography is one of the most important units for continuous manufacturing monoclonal antibody (mAb). Due to complexity three-column periodic counter-current (3C-PCC), three approaches (experimental, model-based, and simplified approaches) were studied process development optimization. The effects residence time interconnected load (RT C ), breakthrough percentage first column (s) feed protein concentration (c 0 ) on productivity capacity utilization...
Chitosan obtained by deacetylation of chitin is the only pseudo-natural cationic polymer and has been widely used for a variety applications. It can crosslink with small molecules or form polyelectrolyte complexes polyanions, these reactions are usually carried out in aqueous solutions under mild conditions without toxic additives organic solvents, which beneficial its application medical pharmaceutical industries. However, reaction processes be affected several factors such as charge...
A new hydrophobic charge-induction chromatography resin was prepared with 5-aminobenzimidazol as functional ligand and polyacrylic ester beads matrix. Adsorption isotherms adsorption in columns were investigated using human immunoglobulin G bovine serum albumin model proteins, the influence of pH NaCl concentration discussed. Results showed that density 195 μmol/mL gel, protein selectivity can be improved by controlling salt addition. An optimized purification process (sample loading at 8.0...
Sortilin is a member of the vacuolar protein sorting 10 (VPS10P) domain receptor family, which carries out signal transduction and transport in cells. serves as third, G-protein uncoupled, neurotensin that can modulate various brain functions. More recent data indicate an involvement sortilin mood disorders, dementia Alzheimer-type neuropathology. However, regarding normal pattern regional cellular expression human are not available to date. Using postmortem adult brains free neuropathology,...
In recent years, some new Qi-Nan clones of Aquilaria sinensis, which have the characteristics easily induced and high-quality agarwood, been selected propagated by grafting seedlings. To date, research on seedlings is limited. this study, effects physiological endophytic fungi within a short period after were studied means histochemical observations, index determinations Illumina sequencing. The results showed that healing time ordinary A. sinensis was at least 10 days shorter than Qi-Nan,...
In this study, Aquilaria sinensis ‘Qinan’, a strain of A. that easily forms agarwood, was selected and propagated by grafting seedlings. Existing research has mainly focused on the characteristics agarwood formation, but little attention been paid to growth ‘Qinan’. rate, photosynthetic capacity, leaf size, carbon nitrogen contents, antioxidant capacity were evaluated during early stage in ‘Qinan’ grafted Compared with sinensis, exhibited higher net rate (9.2 μmol m−2 s−1 7.8 sinensis)...