Wenli Zhu

ORCID: 0009-0005-2006-6378
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About
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Research Areas
  • Chemical Synthesis and Reactions
  • Sulfur-Based Synthesis Techniques
  • Synthesis of Indole Derivatives
  • Rice Cultivation and Yield Improvement
  • Organoselenium and organotellurium chemistry
  • Food Quality and Safety Studies
  • Click Chemistry and Applications
  • Fermentation and Sensory Analysis
  • Proteins in Food Systems
  • Plant biochemistry and biosynthesis
  • Gestational Diabetes Research and Management
  • Meat and Animal Product Quality
  • Vanadium and Halogenation Chemistry
  • Asymmetric Synthesis and Catalysis
  • Lipid metabolism and biosynthesis
  • Tryptophan and brain disorders
  • Genetics and Neurodevelopmental Disorders
  • Neuroscience and Neural Engineering
  • Catalytic C–H Functionalization Methods
  • Inflammatory Bowel Disease
  • Catalytic Cross-Coupling Reactions
  • Food Chemistry and Fat Analysis
  • Multicomponent Synthesis of Heterocycles
  • Radical Photochemical Reactions
  • Peroxisome Proliferator-Activated Receptors

Wuhu Fourth People Hospital
2022-2025

The Fourth People's Hospital
2022-2025

Zhejiang Medicine (China)
2025

Sichuan Agricultural University
2024

Xinjiang University
2022-2024

Yangzhou University
2024

Hunan University
2024

Chemical Synthesis Lab
2024

Obstetrics and Gynecology Hospital of Fudan University
2022

National Institute of Clean and Low-Carbon Energy
2022

Direct C(sp 3 )-H selenation, which is most atom economical, remains a formidable challenge, and only few examples have been reported to date. In this article, we introduce the transition metal-free selenation with β-ketosulfones diselenides as material source.

10.1039/d4ob00006d article EN Organic & Biomolecular Chemistry 2024-01-01

<title>Abstract</title> Heat Shock Protein Family A Member 1B (<italic>Hspa1b</italic>) is an RNA-binding protein (RBP), which essential for transcriptional regulation and post-transcriptional control of RNAs. While previous studies have demonstrated its protective role in stress adaptation post-injury depression, function major depressive disorder (MDD) remains unclear. To investigate the <italic>Hspa1b</italic> MDD, we established a mouse model with hippocampal overexpression. Integrated...

10.21203/rs.3.rs-6192393/v1 preprint EN cc-by Research Square (Research Square) 2025-03-28

Peroxygenated compounds have wide applications in various fields, including chemistry, pharmaceutical medicine, and materials science. However, there is still a need for more efficient environmentally friendly synthesis methods such compounds. Herein, we investigated the two-step, one-pot, regioselective of α/β-aromatic peroxy thiols. We explored substrates solvents reaction identified optimal conditions. successfully obtained several thiols moderate to good yields via selective generation...

10.1021/acs.joc.3c02518 article EN The Journal of Organic Chemistry 2024-02-09

Available online A mild and efficient photocatalytic-induced radical method has been developed for [4 ​+ ​1] cycloaddition reaction of 1,4-disubstituted 1,2,3-triazoles with N-tosylhydrazides primary amines. The is catalyzed by 20 ​mol% I2 under metal, azide oxidant-free conditions. based upon the photocatalytic generation allyl-type radicals, followed iodine-catalyzed production azoalkenes, which react rapidly various anilines.

10.1016/j.gresc.2023.05.001 article EN cc-by-nc-nd Green Synthesis and Catalysis 2023-05-24

A protocol for selective and efficient synthesis of symmetrical unsymmetrical

10.1021/acs.joc.4c00790 article EN The Journal of Organic Chemistry 2024-07-22

Mandelates and their derivatives are widely used in organic synthesis, drug discovery, biodegradable polymers other related fields. Therefore, the effective simple synthesis of these compounds has attracted much attention. In this paper, a nickel(II)-catalyzed esterification mandelic acids with different alcohols was realized for acid esters. This transformation conducted under mild reaction conditions yields up to 95%, successfully utilized gram-scale medicine cyclandelate.

10.1016/j.arabjc.2022.104407 article EN cc-by-nc-nd Arabian Journal of Chemistry 2022-11-11

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10.2139/ssrn.4768848 preprint EN 2024-01-01

As a starchy and edible tropical plant, cassava (Manihot esculenta Crantz) has been widely used as an industrial raw material dietary source. However, the metabolomic genetic difference in specific germplasms of storage root was unclear. In this study, two M. Crantz cv. sugar GPMS0991L pink BRA117315 were research materials. This study found that rich sucrose fructose, starch glucose, respectively. Combined transcriptomic analysis indicated metabolism had significantly changing metabolites...

10.2139/ssrn.4364314 article EN 2023-01-01

Long QT syndrome is one of the most common hereditary arrhythmias in clinic. Mutations AKAP9 gene can lead to long type 11 (LQT11). In this study, a human induced pluripotent stem cell line ZZUSAHi004-A from 3-year-old male patient with carrying heterozygous mutation using non-integrative Sendai viral reprogramming technology. showed normal karyotype (46, XY), expressed pluripotency markers and could differentiate into all three germ layers vitro. serve as disease model understanding LQT11...

10.1016/j.scr.2022.102966 article EN cc-by-nc-nd Stem Cell Research 2022-11-12

As a starchy and edible tropical plant, cassava (Manihot esculenta Crantz) has been widely used as an industrial raw material dietary source. However, the metabolomic difference in different colors of storage root is unclear. In this study, two specific germplasms WFSR with white flesh PFSR pink were research materials. A previous study found that was rich sucrose fructose, starch glucose. Combined transcriptomic analysis indicated metabolism had SCMs enrichment highest degree DEGs,...

10.2139/ssrn.4259898 article EN 2022-01-01
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