A5006869604- Pancreatic function and diabetes
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Developmental Biology and Gene Regulation
- Macrophage Migration Inhibitory Factor
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Antibiotic Resistance in Bacteria
- Image Processing and 3D Reconstruction
- Immune Cell Function and Interaction
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Water Treatment and Disinfection
- Sirtuins and Resveratrol in Medicine
- Folate and B Vitamins Research
- Clostridium difficile and Clostridium perfringens research
- Redox biology and oxidative stress
- Nanoplatforms for cancer theranostics
- Phytochemical and Pharmacological Studies
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
Westlake University
2019-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020-2025
Huazhong Agricultural University
2021-2022
Wenzhou Medical University
2016-2022
First Affiliated Hospital of Wenzhou Medical University
2016-2022
Broad Institute
2016-2019
Massachusetts General Hospital
2013-2019
Harvard University
2013-2019
Center for Human Genetics
2016
Institute of Biophysics
2011
Vitamin B12 (B12) deficiency is a critical problem worldwide. Such in infants has long been known to increase the propensity develop obesity and diabetes later life through unclear mechanisms. Here, we establish Caenorhabditis elegans model study how early-life impacts adult health. We find that causes increased lipogenesis lipid peroxidation worms, which turn induces germline defects ferroptosis. Mechanistically, show central role of methionine cycle-SBP-1/SREBP1-lipogenesis axis...
Metformin (MET), a worldwide used drug for type 2 diabetes, has been found with the largest amount by weight among all drugs in aquatic environment, including drinking water systems where this emerging micropollutant is inevitably transformed during chlorination process. Whether MET byproducts Y (C4H6ClN5) and C (C4H6ClN3) exist remains unknown. Although health-promoting properties, whether or how its affect health still uncharacterized. Here we reveal that byproduct are present highest...
The Notch signaling pathway controls cell growth, differentiation, and fate decisions, its dysregulation has been linked to various human genetic disorders cancers. To comprehensively understand the global organization of identify potential drug targets for Notch-related diseases, we established a protein interaction landscape pathway. By combining analyzing phenotypic data with bioinformatics analysis, greatly expanded this identified many key regulators, including...
Abstract Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring adult traits are largely unknown. Here, using body size as the primary readout, we reveal that maternal rather than paternal an evolutionarily conserved effect on humans, Drosophila , Caenorhabditis elegans . Elucidating mechanisms of such effects humans other long-lived animals remains challenging due their long life course difficulties conducting vivo studies....
Abstract Years of use the antidiabetic drug metformin has long been associated with risk vitamin B12 (B12) deficiency in type 2 diabetes (T2D) patients, although underlying mechanisms are unclear. Accumulating evidence shown that may exert beneficial effects by altering metabolism gut microbiota, but whether it induces human via modulation bacterial activity remains poorly understood. Here, we show both and other biguanide phenformin markedly elevate accumulation E. coli . By functional...
Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis pathways are principal determinants of survival. Reduced function cytoplasmic aminoacyl tRNA synthetases (ARS genes) increases mass and extends survival, whereas reduced proteasomal reduces These converge on AMP-activated protein kinase (AMPK)...
A hallmark of type 2 diabetes (T2D) is hepatic resistance to insulin's glucose-lowering effects. The serum- and glucocorticoid-regulated family protein kinases (SGK) activated downstream mechanistic target rapamycin complex (mTORC2) in response insulin parallel AKT. Surprisingly, despite an identical substrate recognition motif AKT, which drives sensitivity, pathological accumulation SGK1 resistance. Liver-specific Sgk1-knockout (Sgk1Lko) mice display improved glucose tolerance sensitivity...
Background . Macrophage migration inhibitory factor (MIF) is an important immunoregulatory cytokine involved in inflammation, which may be one reason resulting matrix deposition renal tissues after injury. However, the underlying mechanisms have not yet been elucidated. Methods and Results We uncovered a crucial role of MIF inflammation collagen vivo vitro In rats, ureteral obstruction induced tubular injury, accumulation, inflammatory cell infiltration. Additionally, enhanced levels...
Human granzyme H (GzmH) is constitutively expressed in human NK cells that have important roles innate immune responses against tumors and viruses. GzmH a chymotrypsin-like serine protease. Its substrate preference its mechanism of recognition are poorly understood. To provide structural insights into the mechanisms for GzmH, we solved crystal structures D102N-GzmH mutant alone complex with decapeptide an inhibitor to 2.2 Å, 2.4 2.7 respectively. The Thr(189), Gly(216), Gly(226) specificity...
The target of rapamycin complex 2 (TORC2) pathway is evolutionarily conserved and regulates cellular energetics, growth metabolism. Loss function the essential TORC2 subunit Rictor (RICT-1) in Caenorhabditis elegans results slow developmental rate, reduced brood size, small body increased fat mass truncated lifespan. We performed a rict-1 suppressor RNAi screen genes encoding proteins that possess phosphorylation sequence AGC family kinase SGK, key downstream effector TORC2. Only to dpy-21...
Background Given the high mortality of bacterial bloodstream infections (BSI), blood culture results do not meet clinical needs timely due to being time-consuming and having low positive rate. Whether we can identify severity type by cytokines is a controversial issue. Objective To investigate dynamic change in BSI. Methods 55 patients with Gram-positive (GP) BSI, 64 Gram-negative (GN) BSI 52 healthy controls were enrolled. We quantitatively detected interleukin (IL)-2, IL-4, IL-6, IL-10,...
The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of has been linked to various human diseases. receptor resides in multiple cellular compartments, its translocation plays a central role activation. However, the spatial regulation functions remains largely elusive. Using TurboID-based proximity labeling followed by affinity purification mass spectrometry, we establish spatially defined interaction network. receptors interact with different...
To gain further insights into the predisposing risk factors for central nervous system (CNS) involvement in patients with acute lymphocytic leukemia (ALL), impact of CD56 expression these was investigated.We reviewed clinical features 588 consecutive ALL treated systemic chemotherapy regimens between 2000 and 2014. The categorical data from CD56+ were compared those CD56- patients.Among studied, 18.9% showed expression. significantly associated CD33+, CD10-, CD15+, TdT-, CD5+...
Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of function. MicroRNAs (miRNAs/miRs) are small non-coding molecules may be involved in the progression many diseases. The aim present study was investigate roles miRNAs, including miR-125b, miR-326 miR-324p, obstructive injury. Blood samples were collected from 91 patients with ureteral obstruction 76 controls examine In addition, levels miR-324p determined by...
The target of rapamycin complex 2 (TORC2) pathway is evolutionarily conserved and regulates cellular energetics, growth metabolism. Loss function the essential TORC2 subunit Rictor (RICT-1) in Caenorhabditis elegans results slow developmental rate, reduced brood size, small body increased fat mass truncated lifespan. We performed a rict-1 suppressor RNAi screen genes encoding proteins that possess phosphorylation sequence AGC family kinase SGK, key downstream effector TORC2. Only to dpy-21...