A5111900908- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Cancer-related molecular mechanisms research
- Amoebic Infections and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Parasitic Infections and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parasite Biology and Host Interactions
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Synthesis and biological activity
- Liver physiology and pathology
- Parasites and Host Interactions
- Gastroesophageal reflux and treatments
- Extracellular vesicles in disease
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Phytase and its Applications
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
Southern Medical University Shenzhen Hospital
2018-2025
Xinjiang Medical University
2011-2018
First Affiliated Hospital of Xinjiang Medical University
2011-2018
The role of autotransplantation in end-stage hepatic alveolar echinococcosis (AE) is unclear. We aimed to present our 15-case experience and propose selection criteria for autotransplantation. All patients were considered have unresectable AE by conventional resection due critical invasion retrohepatic vena cava, hepatocaval region along with three veins, the tertiary portal arterial branches. successfully underwent ex vivo extended right hepatectomy without intraoperative mortality. median...
Colorectal cancer (CRC) is a common malignant tumor. Circular RNAs (circRNAs) have been reported to take part in the progression of CRC. However, functions circ_0084615 CRC development are still undefined. In this study, we aimed explore and underlying mechanisms CRC.qRT-PCR, western blot assay IHC were utilized for levels circ_0084615, miR-599, ONECUT2 or EIF4A3. 5-ethynyl-2'-deoxyuridine (EdU) colony formation conducted cell proliferation ability. Wound-healing transwell applied evaluate...
Summary Echinococcosis is a chronic parasitic infectious disease regulated by T‐cell subsets. CD4 + CD25 FoxP3 regulatory T (Treg) cells and Th17 have been described as two distinct subsets the opposite effect on inflammation. Th17/Treg balance controls inflammation may play an important role in pathogenesis of immune evasion. To assess whether this was broken, we detected functions different levels including cell frequencies, related cytokines secretion key transcription factors patients...
A close relationship between cancer progression and microRNAs (miRNAs) regulation has been demonstrated. Abnormal microRNA-206 (miR-206) expression shown to be related the development of malignancies. However, role miR-206 in hepatocellular carcinoma (HCC) remains unclear. Here, we evaluated function HCC. Results showed that was decreased 27 human HCC tissues compared with adjacent normal tissues. Conversely, cMET up-regulated tissues, levels were negatively correlated expression. Abnormally...
Gallbladder cancer (GBC) is a refractory primary cancer. Some GBC patients are prone to recurrence even after surgical resection. In such cases, chemotherapy the most common non-surgical treatment. The emergence of programmed cell death protein 1 (PD-1) inhibitors and targeted therapy have provided an additional option for those suffering from advanced tumors. This was retrospective study involving with treated at Shanghai Eastern Hepatobiliary Surgery Hospital between June 2019 2022. who...
Introduction: A prediction model for the 1-, 3-, and 5-year survival rates of metastatic colon cancer (mCC) patients was developed by analyzing important risk factors prognosis mCC based on SEER database. Method: The characteristic 10,946 diagnosed with between 2010 2015 obtained from population randomly divided into a training cohort an internal validation in 7:3 ratio. Univariate multivariate cox independent predictors were performed, nomogram constructed. accuracy verified calibration...
Background: This research explores the significance of miR-215-5p and vasculogenic mimicry (VM) in forecasting prognosis for hepatocellular carcinoma (HCC). Methods: We analyzed HCC-associated miRNA expression profiles using data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Samples included tissue blood 80 early-stage HCC patients serum 120 healthy individuals. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was employed to measure zinc finger...
Objectiye To investigate the value of liver transplantation for treatment end-stage hepatic alveolar echinococcosis(HAE).Methods The clinical data 8 patients with HAE who received at First Affiliated Hospital Xinjiang Medical University from December 2000 to August 2010 were retrospectively analyzed.The operation time,anhepatic phase,infusion suspension red blood cells and postoperative complications observed.Results median phase infusion 635 minutes(range,490-760 minutes),66...
Objective To observe bone mesenchymal stem cells (BMSCs) influence on the development of liver fibrosis.Methods We choose 20 female Wistar rats which randomly divided into intervention group (10 rats) and control rats).Interventional were accepted water involve consistency as 0.01％ diethylnitrosamine.In 4,8,12 week we transplant 1 × 106 BMSCs suspension male rat to interventional through caudal vein.Control injected equal normal saline vein.The breed in same condition for 21 weeks observed...
A Correction to this paper has been published: https://doi.org/10.1038/s41417-021-00338-0
Objective To evaluate laparoscopic radical resection of liver hydatid cyst as compared with conventional open surgery.Methods From May 2006 to January 2013 clinical data 41 patients undergoing hepatic were those 112 cases treated by surgery.Operation time,blood loss,conversion rate,length hospitalization and recurrence rate analyzed.Results There was not statistical significant difference in operative time blood loss between the two groups (t =1.97,P ＞ 0.05) =2.00,P 0.05).Five converted...
Objective To investigate the clinical safety and prognosis of laparoscopic pericystectomy in treatment hepatic cystic echinococcosis.Methods The data 21 patients with echinococcosis who received at First Affiliated Hospital Xinjiang Medical University were retrospectively analyzed.Albendazole [10 mg/(kg · d)] was administered orally to all 1 week before operation.All followed up via outpatient examination phone call till June 2012.The rate transfer open surgery operation time,volume blood...
Objective To study the operative techniques and surgical results of hepatic alveolar echinococcosis. Methods Forty three patients with echinococcosis treated in our Hospital from 2000 to 2008 were studied retrospectively. They divided into two groups: radical resection group (19 cases) palliative (24 cases). Results There 1 surgeryrelated death, 2 remote metastases, intrahepatic dissemination, 4 recurrent jaundice 3 cholangitis group. biliary fistula, patient emaciation Among 30 followed-up...
Objective To summarize the clinical experience of living donor liver transplantation (LDLT) relatives for end-stage disease (ESLD). Methods Clinical data 12 donors (7 males and 5 females; 19 to 51 years age; 28 mean age) recipients 13 39 who underwent LDLT in First Affiliated Hospital, Xinjiang Medical University from September 2005 2012 were retrospectively analyzed. The real kinship between was carefully identified proved. informed consents all participating subjects obtained...
Objective To explore the clinical effect of laparoscopic fundoplication in treatment gastroesophageal reflux disease(GERD). Methods Clinical data patients with GERD The First Affiliated Hospital Xinjiang Medical University by laparoscopy was analyzed from January 2008 to June 2014.Among patients, simple Toupt carried out 9 cases, combined hiatal herniorraphy performed on other 73 cases(Nissen and Toupet 64). Results All had successfully completed operation, operation time ranged...
Early development of liver cancer is usually asymptomatic. The overall survival rate patients relatively low due to late diagnosis, despite hepatocellular carcinoma being a common diagnosis. high mortality was its overactivated cellular mitochondrial activities, namely thioredoxin reductase enzymatic activities and downstream activation nuclear factor kappa B (NF-κB) signaling pathways for cell migration. Our previous study on this candidate compound A2780 ovarian cells MCF-7 breast cells,...