A5087858249- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Liver Disease and Transplantation
- Liver physiology and pathology
- Vaccine Coverage and Hesitancy
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- 3D Printing in Biomedical Research
- Inflammatory Biomarkers in Disease Prognosis
- Mathematical Biology Tumor Growth
- Ocular Oncology and Treatments
- Nanopore and Nanochannel Transport Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Traditional Chinese Medicine Studies
- Lung Cancer Treatments and Mutations
- Biological and pharmacological studies of plants
- Long-Term Effects of COVID-19
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Artificial Intelligence in Healthcare
Nanjing Second Hospital
2014-2025
Nanjing University of Chinese Medicine
2019-2023
Second Affiliated Hospital of Nanjing Medical University
2023
Nanjing Municipal Center for Disease Control And Prevention
2023
Southeast University
2016
With the outbreak of COVID-19, which is fast transmitting and highly contagious, development rapid, specific, sensitive detection kits has become a research hotspot. The existing assay methods for SARS-CoV-2 are mainly based on enzymatic reactions, require expensive reagents, hindering popular use, especially in resource-constrained areas. Herein, we propose an aptamer-based method via binding spike protein using functionalized biomimetic nanochannels. To get analogous effect human ACE2,...
Leukocyte immunoglobulin-like receptor subfamily B (LILRB), including 5 subtypes, is a group of inhibitory receptors in the immune system. The LILRB family known to be involved tumor progression various cancer types, especially liver cancer. However, expression patterns and prognostic values members tissues remain unclear.We used Oncomine database, GEPIA Kaplan-Meier Plotter, Timer, TISIDB assess value patients. We also verified tumor-free at protein level by using immunohistochemistry....
To investigate the usefulness of inflammation biomarkers to serve as a predictors portal vein thrombosis (PVT) postoperatively (post) in patients with hypertension after splenectomy and periesophagogastric devascularization.A total 177 liver cirrhosis were recruited from January 2013 December 2017. They divided into PVT group (n=71) non-PVT (n=106), according ultrasound examination findings at 7-day post. Inflammation involving platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte...
Background: Hepatocellular carcinoma (HCC) is a common clinical malignant disease and the second leading cause of cancer-related death worldwide. Dendrobium commonly applied nourishing drug in traditional Chinese medicine. Gigantol phenolic compound extracted from Dendrobium. The has attracted attention for its anticancer effects. However, mechanism gigantol HCC not been extensively explored. Methods: Potential targets were predicted by SwissTargetPrediction. HCC-related genes obtained...
The present retrospective study aimed to investigate the mid‑term safety and efficacy of hepatectomy combined with microwave ablation partial spleen for treatment liver cancer complicated hypersplenism. A analysis was performed on 23 patients who underwent cancer, hypersplenism that secondary cirrhosis. splenic ablated volumes were calculated according a contrast‑enhanced computed tomography scan prior 2 weeks after operation. Complete blood count function tests examined following surgery,...
Hepatocellular carcinoma (HCC) is the second leading causes of cancer-related death. HCC usually based on chronic liver disease, mainly including hepatitis C virus infection or B (HBV) infection.The objective study was to evaluate impact nucleos(t)ide analog (NA) use prognosis patients with HBV-related small hepatocellular carcinomas (HBV-SHCC).In this retrospective study, there were 134 who had been treated long-term NA before SHCC diagnosis as NA-experienced group, 43 received NA-naïve...
Liver cancer (LC) is one of the most common malignant tumors worldwide. Since mechanism LC pathogenesis and metastasis cannot be carried out directly on human body, it particularly important to establish liver cell lines for research in vitro. In this study, tissue block adherence method combined with clumps digestion was used primary hepatocytes (PHHs) a successful rate 60% (45/75). Short tandem repeat (STR) analysis proved cells were derived from its paired tissues. These hepatocellular...
The aim of this study is to investigate the effect platelet on improvement deteriorated liver function after resection. Six patients with hepatocellular carcinoma and cirrhosis have received partial hepatectomy in institution. Their Child–Pugh grade was B, count below 7,000/µl. After hepatectomy, 20 units transfusion were carried out, side effects investigated 4 weeks, number platelets increased approximately 15,000/µl. Liver functions, such as aspartate transaminase (AST), alanine...
Objective To evaluate the predictive effect of preoperative CTP score,MELD score and MELD-Na on short-term prognosis (≤ 3 months) after liver transplantation,to analyze factors which correlated with survival,and to seek indicators that accurately predicted outcomes.Methods The clinical data 73 consecutive patients end-stage diseases who underwent transplantation in a single center were retrospectively analyzed.The area under ROC curve (AUC) was used determine power.Correlated analyzed by...
The clinical significance of systemic inflammation assessed with laboratory analysis blood samples has been validated in a variety cancers. present study was conducted to investigate prognostic preoperative aspartate aminotransferase-to-platelet ratio index (APRI) for the outcome hepatocellular carcinoma (HCC) patients receiving post-operative adjuvant transarterial chemoembolization (PATACE). A total 201 who underwent PATACE were retrospectively analyzed. nomogram HCC developed using...
Hepatocellular carcinoma (HCC) is considered the sixth most common cancer and third cause of cancer-related death worldwide. In addition, HCC second cancer, only to lung in China (1). Over last 3 decades, incidence rates mortality have gradually increased United States (2). Analysis data from 1990–2014 World Health Organization (WHO) EU indicated that would continue increase through 2020 EU, North America Latin America. However, eastern Asia, are predicted be two five fold compared with...
Objective To analyze many indicators during perioperative period of liver transplantation in patients with end-stage disease, only to seek related factors that can accurately predict short-term(≤three months)outcome. Methods We analyzed retrospectively clinical data consecutive diseases undergone a single treatment center. Logistic regression analysis was used the including recipient gender, age, body mass index, preoperative serum albumin level, sodium concentration, urea nitrogen...
The persistent coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is still infecting hundreds of thousands people every day. Enriching the kits for SARS-CoV-2 detection and developing drugs patient treatments are urgently needed combating spreading virus, especially after emergence various mutants. Herein, an electrochemical biosensor has been fabricated in this work via its papain-like cysteine protease (PLpro) screening...