A5100761771- Dementia and Cognitive Impairment Research
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Selenium in Biological Systems
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects of Natural Compounds
- Medical Research and Treatments
- Mental Health Treatment and Access
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Studies
- Machine Learning in Healthcare
- Alcohol Consumption and Health Effects
- Immune cells in cancer
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Heavy Metal Exposure and Toxicity
- Health disparities and outcomes
- Advanced Glycation End Products research
Jilin University
2013-2025
First Hospital of Jilin University
2013-2025
Jinzhou Medical University
2020-2025
Capital Medical University
2022-2024
University of Utah
2014-2024
Nanyang Technological University
2024
China National Center for Food Safety Risk Assessment
2020-2024
Guangxi Medical University
2020-2023
Ningbo Medical Center Lihuili Hospital
2023
Tianjin Infectious Diseases Hospital
2022
OBJECTIVE : To describe the prevalence of activities daily living (ADL) dependence and medical conditions relationship between illnesses ADL performance in older population Shanghai, China. DESIGN Probability sample survey community residents. SETTING The Jing An district interviews were carried out at homes persons. PARTICIPANTS There 3763 noninstitutionalized elders screened, 3745 whom completed interview. MEASUREMENTS dependent variables five basic items: eating, dressing, transferring,...
Objective: There are few studies of successful aging in China. This study was designed to investigate the distribution, and related factors, an elderly Chinese population.Methods: A cross-sectional, community-dwelling population surveyed Shanghai, We defined based on a multi-dimensional model. Correlates were explored through Shanghai Successful Aging Project Questionnaire, which includes sociodemographic questions, battery standardized instruments, including version Mini-mental State...
Background Early diagnosis of Alzheimer's disease (AD) is imperative for the prevention progression and development effective treatments. Objective Clinically, AD has been based on adherence to clinical criteria. It recently proposed that diagnostic criteria should also incorporate biomarker findings. However, most studied candidates or group biomarkers, including pathological processes proteins, needs further research. The current study aimed investigate capabilities following plasma...
Melatonin (MT) has potential protective effect on cerebral ischemia-reperfusion injury (CIRI), but its underlying regulatory mechanism not been identified.This study aimed to explore the role of miR-26a-5p-neuron-restrictive silencing factor (NRSF/REST), Janus kinase-2 (JAK2)-signal transducer and activator transcription-3 (STAT3) pathway in protection MT against CIRI vivo vitro.Sprague Dawley rats were induced with (IR) model; PC12 cells oxygen-glucose deprivation/reperfusion (OGD/R) vitro...
Objectives: Studies of the prevalence and risk factors for behavioral psychological symptoms dementia (BPSD) have primarily been conducted in nursing home clinic populations. Few population-based studies community-living persons with dementia. Methods: In this cross-sectional study, aged 65 above who were living community screened Chinese version Mini-Mental State Examination (CMMSE) Ability Daily Living (ADL-14) scale. Participants a diagnosis according to DSM-IV criteria made by trained...
Objective China’s national hepatitis burden is high. This study aims to provide a detailed national-level description of the reported incidence viral in China during 2004–2016. Design Observational study. Setting Data were obtained from National Notifiable Disease Reporting System, and changing trends estimated by joinpoint regression analysis. Participants In this system, 16 927 233 cases occurring 2004–2016 identified. Primary outcome measure Incidence rates per 100 000 person-years...
Bovine collagen oligopeptides (BCOP) are small molecule isolated from bovine collagen, which have been proved to modulate the metabolism. However, effects of BCOP on wound healing is rarely known by public. This study aims evaluate beneficial using an excisional model established in mice. Moreover, role PI3K/Akt/mTOR pathway migration fibroblasts vitro further elucidated. It was observed that could significantly reduce size area, increasing albumin and prealbumin levels also inhibit...
Sepsis is a systemic inflammatory reaction caused by infection. Multiple organ failure ultimately leads to high morbidity and mortality. Unfortunately, therapies against these responses have been unsuccessful due the insufficient underlying pathophysiological evidence. Protein interacting with C-kinase 1 (PICK1) has received considerable attention because of its important physiological functions in many tissues. However, role sepsis-induced acute lung injury (ALI) unclear. In this study, we...
To examine socio-demographic associations of transitions from alcohol use to disorders and remission in metropolitan China.Face-to-face interviewing by trained lay-interviewers on a multi-staged, clustered sample the general population Beijing Shanghai, China.A total 5201 adults aged 18-70 years with household registration.World Mental Health version Composite International Diagnostic Interview.Lifetime prevalence estimates for use, regular (at least 12 drinks year), DSM-IV abuse dependence...
Certain circulating cell subsets are involved in immune dysregulation human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) co-infection; however, the characteristics role of these subclusters unknown. Peripheral blood mononuclear cells (PBMCs) patients with HIV-1 infection alone (HIV-pre) those HIV-1-TB co-infection without anti-TB treatment (HIV-pre & TB-pre) for 2 weeks TB-pos) were subjected to single-cell RNA sequencing (scRNA-seq) characterize transcriptome different...
Abstract Objective To evaluate the feasibility, accuracy, and interoperability of a natural language processing (NLP) system that extracts diagnostic assertions pneumonia in different clinical notes institutions. Materials Methods A rule-based NLP was designed to identify 3 types from electronic health records (EHRs): emergency department notes, radiology reports, discharge summaries. The lexicon classification logic were tailored for each note type. first developed evaluated using annotated...
The aim of this study was to propose an analytical approach develop high-performing predictive models for congestive heart failure (CHF) readmission using operational dataset with incomplete records and changing data over time. Our involves three steps: pre-processing, systematic model development, risk factor analysis. For variables that were absent in >50% removed. Moreover, the divided into a validation derivation datasets which separated temporal subsets based on changes different...
Alcohol-associated liver disease is exhibiting an increasing burden. In terms of pathogenesis, inflammation closely related to alcohol-induced injury. The neutrophil-to-lymphocyte ratio (NLR) a novel inflammatory biomarker. Here, we aim evaluate the role NLR and other biomarkers in predicting short-term mortality alcoholic cirrhotic patients.This was retrospective study that included 459 male cirrhosis patients. Among them, 345 patients completed follow-up. Based on their 30-day information,...
Viral integration profiles attract increased interest in the study of HBV-related hepatocellular carcinoma (HCC), but their features early stage infection and changes due to antiviral treatments remain largely unknown.Liver biopsies paired blood samples were obtained from HBeAg-positive patients before after 48 weeks entecavir treatment, a probe-based capture strategy was applied for analyzing HBV integrations these samples. Serum markers, including viral DNA, pgRNA, HBsAg, longitudinally...
Antibiotic allergies are overdiagnosed. This may lead to unnecessary use of second-line broader-spectrum agents in place narrower-spectrum guideline-recommended first-line therapies especially for uncomplicated respiratory tract infections. The extent which this occurs children with infections is unknown.We included outpatient encounters patients < 18 years acute (sinusitis, bronchitis, bronchiolitis, upper infection, pharyngitis, otitis media). Patients were classified as penicillin...