A5100336636- Hormonal and reproductive studies
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Muscle metabolism and nutrition
- Acute Ischemic Stroke Management
- Retinal Imaging and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinal Diseases and Treatments
- Plasma Applications and Diagnostics
- Plasma Diagnostics and Applications
- Environmental Monitoring and Data Management
- Sexual Differentiation and Disorders
- Ear Surgery and Otitis Media
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Exercise and Physiological Responses
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Reconstructive Facial Surgery Techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Stroke Rehabilitation and Recovery
- Tea Polyphenols and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Photonic and Optical Devices
Fudan University
2024-2025
Huashan Hospital
2024-2025
Peking University
2025
Peking University Sixth Hospital
2025
University Medical Center Groningen
2022-2025
University of Groningen
2022-2025
Liaocheng People's Hospital
2025
National Clinical Research
2025
State Key Laboratory of Medical Neurobiology
2025
Beijing University of Chinese Medicine
2024
Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety efficacy of testosterone treatment men who have limitations mobility not studied.
Green tea catechins (GTCs), which include (−)-epicatechin (EC), gallate (ECG), (−)-epigallocatechin (EGC) and (EGCG), possess a variety of biological activities. We have previously studied the effect dietary GTCs as mixture on membrane oxidation red blood cells found that were partially absorbed detected in rats given an oral ingestion 100 mg GTCs. To explain partial absorption their varying free-radical scavenging capacity at different pH, present paper was to study further pH stability...
Concerns about potential adverse effects of testosterone on prostate have motivated the development selective androgen receptor modulators that display tissue-selective activation androgenic signaling. LGD-4033, a novel nonsteroidal, oral modulator, binds with high affinity and selectivity. To evaluate safety, tolerability, pharmacokinetics, ascending doses LGD-4033 administered daily for 21 days lean body mass, muscle strength, stair-climbing power, sex hormones. In this placebo-controlled...
This article has been corrected. The original version (PDF) is appended to this as a supplement. Background: Erectile dysfunction and low testosterone levels frequently occur together. Objective: To determine whether addition of sildenafil therapy improves erectile response in men with levels. Design: Randomized, double-blind, parallel, placebo-controlled trial. (ClinicalTrials.gov registration number: NCT00512707) Setting: Outpatient academic research center. Participants: Men aged 40 70...
Steroid 5α-reductase inhibitors are used to treat benign prostatic hyperplasia and androgenic alopecia, but the role of 5α-dihydrotestosterone (DHT) in mediating testosterone's effects on muscle, sexual function, erythropoiesis, other androgen-dependent processes remains poorly understood.To determine whether muscle mass, strength, hematocrit level, prostate volume, sebum production, lipid levels attenuated when its conversion DHT is blocked by dutasteride (an inhibitor type 1 2).The...
Purpose: To investigate the vascular microcirculation changes in retinal nerve fiber layer (RNFL) normal, glaucoma suspect, and open-angle (OAG) groups using optical coherence tomography–based microangiography (OMAG). Methods: One eye from each subject was scanned with a Cirrus HD-OCT 5000–based OMAG prototype system montage scanning protocol centered at optic head (ONH). Blood flow signals were extracted algorithm. Retinal measured by calculating blood flux index vessel area density within...
Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that noncoding RNAs, including microRNAs long play important roles in development endometriosis.Expression profiling miRNAs endometrial tissue was using microarrays. The most differentially expressed were confirmed quantitative reverse transcriptase-polymerase chain reaction analysis additional...
Obesity is characterized by a chronic low-grade inflammatory condition. Two emerging biomarkers, the systemic immune-inflammation index (SII) and inflammation response (SIRI), have gained attention. However, relationships between obesity SII/SRI remain unclear.
Abstract Background To investigate the incidence of depression in middle-aged and elderly patients with diabetes China influencing factors to provide a theoretical basis improve mental health formulate prevention, control, intervention strategies. Methods The sample this study was obtained from Health Aging Tracking Survey (CHARLS) 2018 survey data, older diabetes(responding “Yes” questionnaire: “Have you ever been told by doctor that have or elevated blood glucose [including abnormal...
Recent studies have identified a complex relationship between methylation patterns and the development of various cancers. Breast cancer (BC) is second leading cause mortality among women. Approximately 5–20% BC patients are at risk brain metastases (BCBM). Although 5-methylcytosine (m5C) has been as an important regulatory modifier, its distribution in BCBM not well understood. This study aimed to investigate m5C BCBM. Samples from (231-BR cells) (MDA-MB-231 groups were subjected...
This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy.Seventy-one postmenopausal who previously underwent hysterectomy oophorectomy had total levels less than 31 ng/dL free 3.5 pg/mL received a standardized transdermal estradiol regimen during 12-week run-in period were randomized receive weekly intramuscular injections placebo 3, 6.25, 12.5,...
Men with prostate cancer who receive androgen deprivation therapy show profound skeletal muscle loss. We hypothesized that the deficiency activates not only ubiquitin-proteasome systems but also autophagy and affects key aspects of molecular cross talk between protein synthesis degradation. Here, 2-month-old male mice were castrated treated either testosterone (T) propionate or vehicle for 7 days (short term) 43 (long term), without hydroxyflutamide. Castrated showed rapid atrophy levator...
The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and mechanisms 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from dental plaque healthy human population. Broth microdilution minimum inhibitory concentrations (MICs) revealed that all isolates were nonsusceptible to oxacillin penicillin G. Most them also resistant trimethoprim (65.7%)...
The coronaviruses have inflicted health and societal crises in recent decades. Both SARS CoV-1 2 are suspected to spread through outdoor routes high-density cities, infecting residents apartments on separate floors or different buildings many superspreading events, often the absence of close personal contact. viability such mode transmission is disputed research literature, there little evidence dose–response relationship at apartment level. This paper describes a study examine airborne...
Testosterone increases fat-free mass (FFM) in men infected with human immunodeficiency virus (HIV), but its effects on muscle performance, physical function, mood, and quality of life are poorly understood. Sixty-one HIV-infected weight loss were randomized to receive weekly intramuscular injections 300 mg testosterone enanthate or placebo for 16 wk. The primary outcome interest was function (walking speed, stair-climbing power, load-carrying ability). Secondary measures included body...
Objective To determine the feasibility of detecting and differentiating middle ear effusions (MEEs) using an optical coherence tomography (OCT) otoscope. Study Design Cross‐sectional study. Setting US tertiary care children’s hospital. Subjects Methods Seventy pediatric patients undergoing tympanostomy tube placement were preoperatively imaged OCT A blinded reader quiz was conducted 24 readers from 4 groups tiered medical expertise. The primary outcome assessed ability to detect...
Objectives Cognitive Behavioral Therapy for Insomnia (CBT-I) is recommended as the first-line treatment insomnia disorders, yet its clinical application rate ranges from 1% to 29%. This study evaluated medical doctors' knowledge, attitudes, and practices regarding use of CBT-I in treatingpatients with insomnia.