A5060769703- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Advanced Nanomaterials in Catalysis
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- Biomedical Ethics and Regulation
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Microfluidic and Bio-sensing Technologies
- Viral gastroenteritis research and epidemiology
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
Mengchao Hepatobiliary Hospital
2013-2025
Fujian Medical University
2013-2025
Capital Medical University
2024
Fuzhou Pulmonary Hospital of Fujian
2017
The role of genetic factors in the occurrence and progression CHB (CHB) is still not fully explored. In recent years, genome-wide association studies on patients have demonstrated that a large number CHB-associated single nucleotide polymorphisms exist gene intron, which may regulate expression at transcriptional level. Modification RNA m 6 A methylation one key mechanisms regulating expression. Here we show METTL16 , an regulator involved mRNA intron splicing, differentially expressed...
Abstract miR-34a targeting on Smad4 plays important role in TGF-β1 pathway which is a dominant factor for balancing collagen production and degradation hepatic stellate cells. TGF-β1/Smad4 regulated deposition hallmark of fibrosis. The potential regulation by LncRNAs cells (HSCs) still reserved to be revealed. In current study, it was hypothesized that interactor, lncRNA CCAT2 may regulate liver fibrotic remodeling. interaction between miR-34a-5p checked dual luciferase assay. the effects...
The peak of COVID-19 infections in China has just passed, and symptomatic manifestations patients vary widely, with a minority experiencing severe morbidity mortality. Early detection adverse outcomes remains critical for clinical governance prognosis COVID-19. This review synthesized both national international studies relevant to the prognostic evaluation summarized implications demographics (age gender), specific laboratory parameters, adjunctive examination results, complications,...
This study aimed to compare the serum lipid profiles between tenofovir disoproxil fumarate (TDF) and alafenamide (TAF) in long-term treatment of chronic hepatitis B (CHB). We analyzed data from treatment-naïve CHB patients administered with TDF or TAF, collected electronic medical records May 2017 September 2022. Serum indices, including total cholesterol (TC), triglycerides (TG), low-density (LDL) high-density lipoprotein (HDL), their ratios (TC/HDL, LDL/HDL), were assessed at baseline, 48...
To evaluate the efficacy and safety of telbivudine in chronic hepatitis B women during second third trimesters pregnancy. The week 12–34 pregnant were screened this prospective non-intervention study, with HBV DNA > 106 IU/mL alanine aminotransferase 50 IU/L. patients received treatment as a group or without antiviral control group. All infants recombinant vaccine 10 μg within 12 h birth, at 4 24, immunoglobulin G birth detected markers range from 7 to months after delivery. A total 241...
Addressing the inhibition and reversal of chronic hepatitis B fibrosis is an urgent global challenge, which highlights critical need to understand its underlying mechanisms. Inhibiting activation hepatic stellate cells (HSCs) important strategy for reversal. In particular, induction ferroptosis in HSCs presents a promising avenue curtailing liver fibrosis. Therefore, this study explores influence PR/SET domain 1 (PRDM1), transcriptional regulator, on progression by regulating HSC through...
Spontaneous bacterial peritonitis (SBP) is a life-threatening complication in patients with cirrhosis. We aimed to develop an explainable machine learning model achieve the early prediction and outcome interpretation of SBP. used CatBoost algorithm construct MODEL-1 46 variables. After dimensionality reduction, we constructed MODEL-2. calculated compared sensitivity negative predictive value (NPV) Finally, SHAP (SHapley Additive exPlanations) method provide insights into model's or...
Objective Hepatic encephalopathy (HE) is a serious complication of acute-on-chronic liver failure (ACLF) that requires early detection and intervention to positively impact patient prognosis. This study aimed develop reliable model predict HE in ACLF patients during hospitalization.
Introduction: Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive disease characterized by episodes of severe pruritus and jaundice. Although the symptom will relieve spontaneously without leaving any hepatic injury, ceaseless attacks would reduce life quality patients. However, there not validated treatment for BRIC yet. Considering limited cases unpredictability this disease, publications well-described case reports are necessary investigation development...
Hepatitis B virus (HBV) infection is still a worldwide disease, which may cause liver cirrhosis or even hepatocellular carcinoma. Telbivudine potent nucleoside analogue used in the treatment of chronic hepatitis (CHB); however, drug resistance has remained challenge. As early virological response can predict long-term efficacy nucleotide treatment, numerous studies have been conducted this area.The aim study was to establish baseline prognostic factors and statistical model...
Hepatitis B virus-related liver cirrhosis (HBV-LC) is susceptible to bacterial infections, which could lead adverse prognosis in patients. MicroRNAs (miRs/miRNAs) are easily detected peripheral blood and involved multiple diseases. The present pilot study aimed investigate differentially expressed (DE) miRNAs the serum of patients with HBV-LC infection, identify potential biomarkers. first batch clinical samples was collected, including four without chronic hepatitis (CHB) healthy controls....
Abstract In plasma, miR-34a could be one of potential biomarkers for frailty and is involved in the physiology processes which are benefit from exercise. One its targets, Smad4 play important role TGF-β1 pathway a dominant factor balancing collagen production degradation hepatic stellate cells. TGF-β1/Smad4 regulated deposition hallmark fibrosis. Thus, link between exercise disease. The regulation on by LncRNAs cells (HSCs) still reserved to revealed. current study, it was hypothesized that...
Objective: To investigate and analyze the energy metabolism characteristics correlation between risk of secondary bacterial infection in patients with hepatitis B virus-related chronic liver disease (HBV-CLD). Methods: Data 183 cases admitted to Mengchao Hepatobiliary Hospital Fujian Medical University from November 2017 2020 were retrospectively analyzed. 79 B, 51 B-related cirrhosis, 53 failure collected. Among them decompensated cirrhosis defined as severe group. The Quark RMR indirect...
Objective To investigate the baseline independent prognostic factors for 24 months survival of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (ACLF) patients treated with telbivudine. Methods The prospective cohort study was conducted in HBV-associated ACLF who were hospitalized Mengchao Hepatobiliary Hospital Fujian Medical University and volunteered to be telbivudine more than months. The observed at month 1, 3, 6, 12, after treatment. biochemical index, coagulant...