A5056126101- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Nanocomposite Films for Food Packaging
- biodegradable polymer synthesis and properties
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Microencapsulation and Drying Processes
- Carbon and Quantum Dots Applications
- Diabetic Foot Ulcer Assessment and Management
- Radiation Therapy and Dosimetry
- Phytoestrogen effects and research
- Protein purification and stability
- Ion Transport and Channel Regulation
- Luminescence Properties of Advanced Materials
- Medicinal Plants and Neuroprotection
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
Fuzhou University
2015-2025
Fujian Provincial Cancer Hospital
2025
Harbin Institute of Technology
2012
University of Shanghai for Science and Technology
2011
Institute of Food Science and Technology
2011
Institute of Food Science & Technology
2011
This paper proposes a highly efficient antibacterial system based on synergistic combination of photodynamic therapy, photothermal and chemotherapy. Chitosan oligosaccharide functionalized graphene quantum dots (GQDs-COS) with short-term exposure to 450 nm visible light are used promote rapid healing in bacteria-infected wounds. The GQDs undergo strong photochemical transformation rapidly produce radical oxygen species heat under illumination, while the COS has an innate antimicrobial...
Most anticancer treatments only induce the death of ordinary cancer cells, while stem cells (CSCs) in quiescent phase cell division are difficult to kill, which eventually leads drug resistance, metastasis, and relapse. Therefore, CSCs also important targeted therapy. Herein, we developed dual-targeted glutathione (GSH)-responsive novel nanoparticles (SSBPEI-DOX@siRNAs/iRGD-PEG-HA) efficiently specifically deliver both doxorubicin small interfering RNA cocktails (siRNAs) (survivin siRNA,...
Multiresponsive and biocompatible self-healing ε-PL/A-Pul/BPEI hydrogels were prepared in aqueous solution by Schiff base reaction with aldehyded pullulan (A-Pul), ε-poly-L-lysine (ε-PL) branched polyethyleneimine (BPEI) as materials. The imine bonds rapidly cross-linked into a hydrogel network within 80 s. Scanning electron microscopy images showed that the exhibited structure average pore size from 58 to 82 μm. Rheology tests indicated maintained good mechanical properties. Water contact...
Herein, a dual drug-loaded hydrogel delivery system was constructed using aldehyded pullulan (A-Pul), ε-poly-l-lysine (ε-PL), and branched polyethylenimine (BPEI) in an aqueous solution via Schiff base reaction. CDDP DOX were loaded into the network of hydrogels for combination drug therapy. Gelation time changed from 40 s to 240 when reaction solutions stored at different temperatures. Scanning electron microscopy images swelling dynamics demonstrated that had homogeneous porous structure...
Nano-sensitizers play key roles in tumor radiotherapy several ways to overcome radioresistance and enhance radioresponse. This review summarizes the recent advances of nano-sensitizers improving cancer radiotherapy.
Summary RNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species‐dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu + )‐containing disulfide assembled ‐siRNA), demonstrating remarkable species independence efficient systemic gene silencing across different species. Our results indicate this approach effectively utilizes the vascular system to deliver...
To investigate the cellular function of SOX18 in nasopharyngeal carcinoma (NPC) by analyzing its effects on tumor cell proliferation, apoptosis, migration and invasion, to verify expression prognostic significance clinical samples, thereby providing a basis for precise diagnosis treatment. was analyzed NPC lines samples. Gene silencing techniques were utilized reduce cells, followed assays evaluate migration, invasion. Additionally, changes Wnt/β-catenin signaling pathway examined. High...
Cisplatin (CDDP) has been considered as one of the most effective anticancer drugs against cervical cancer, but lack selectivity CDDP to tumor tissues often leads serious toxic side effects. In this study, CDDP-incorporated Cy5.5-PEG- g-A-HA nanoparticles were prepared endue ability selectively target tumors and fluorescence imaging in vivo. The exhibited a spherical shape with particle sizes between 216.4 281.5 nm had pH Cl- concentration dependence on controlled sustained release, which...
Abstract Despite aminoglycosides (AGs) have superior antibacterial ability, all approved AGs by FDA are associated with adverse effects such as ototoxicity and nephrotoxicity. To solve these problems, hydrogels based on dynamic covalent bond cross‐linking were quickly prepared within 25 s using AGs, aldehyde hyaluronic acid (A‐HA), adipic dihydrazide graft (HA‐ADH) materials. FT‐IR, thermal analysis, SEM results exhibited that A‐HA/HA‐ADH/AGs successfully synthesized highly porous...
Aldehyde hyaluronic acid-cisplatin (A-HA-CDDP) complex nanoparticles were readily prepared, and CDDP was stably loaded into the core of NPs through imine bond coordinate linkages. The results show that prepared successfully by a chemical complexation reaction rather than physical mixing. Compared to many HA evaluated in other studies, A-HA-CDDP with bonds between A-HA displayed better sustained release behavior pH sensitivity. Therefore, acidic tumor environment could accelerate from NPs....