A5033738107- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Viral Infections and Outbreaks Research
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Tuberculosis Research and Epidemiology
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- MicroRNA in disease regulation
- Vibrio bacteria research studies
- NF-κB Signaling Pathways
- Studies on Chitinases and Chitosanases
- Inflammasome and immune disorders
- Aquaculture disease management and microbiota
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
Fujian Medical University
2015-2024
Mengchao Hepatobiliary Hospital
2016-2024
Chinese University of Hong Kong
2018
Beijing Ditan Hospital
2018
Capital Medical University
2018
Fuzhou Pulmonary Hospital of Fujian
2016-2018
The yellow fever virus (YFV) recently reemerged in the large outbreaks Africa and Brazil, first imported patients into Asia have recalled concerns of YFV evolution. Here we show phylogenomics with serial clinical samples 2016 infections. Phylogenetics exhibited that strains were close to Angola 1971 only three amino acid changes presented new other lineages. Deep sequencing viral genomes discovered 101 intrahost single nucleotide variations (iSNVs) 234 polymorphisms (SNPs). Analysis iSNV...
Dengue fever (DF) could develop into dengue haemorrhagic (DHF) with increased mortality rate. Since the clinical characteristics and pathogen are same in DF DHF. It's important to identify different molecular biomarkers predict DHF patients from DF. We conducted a plasma proteomics study using quantification (TMT)-based quantitative methodology found differential expressed protein before they developed In total 441 proteins were identified up or down regulated. There enriched diverse...
Talaromyces marneffei (TM) is an emerging pathogenic fungus that can cause a fatal systemic mycosis in patients infected with human immunodeficiency virus (HIV). Although global awareness regarding HIV/TM coinfection increasing little known about the mechanism mediates rapid progression to HIV/AIDS disease coinfected individuals. The aim of this study was analyze serum proteome and identify associated protein biomarkers for TM HIV/AIDS.We systematically used multiplexed isobaric tandem mass...
Abstract Despite aminoglycosides (AGs) have superior antibacterial ability, all approved AGs by FDA are associated with adverse effects such as ototoxicity and nephrotoxicity. To solve these problems, hydrogels based on dynamic covalent bond cross‐linking were quickly prepared within 25 s using AGs, aldehyde hyaluronic acid (A‐HA), adipic dihydrazide graft (HA‐ADH) materials. FT‐IR, thermal analysis, SEM results exhibited that A‐HA/HA‐ADH/AGs successfully synthesized highly porous...
Cadaverine is produced in organisms from the amino acid lysine a decarboxylation reaction catalyzed by decarboxylase (EC 4.1.1.18). The inducible CadA plays vital role stress response for enteric bacteria. Vibrio vulnificus an extremely virulent human pathogen causing gastroenteritis when conditions that prevent survival of V. stomach or small intestine are overcome. A gene encoding was identified vulnificus. Subsequent analyses showed (VvCadA) decamer with 82-kDa subunit. Homogenous VvCadA...
Abstract miR-34a targeting on Smad4 plays important role in TGF-β1 pathway which is a dominant factor for balancing collagen production and degradation hepatic stellate cells. TGF-β1/Smad4 regulated deposition hallmark of fibrosis. The potential regulation by LncRNAs cells (HSCs) still reserved to be revealed. In current study, it was hypothesized that interactor, lncRNA CCAT2 may regulate liver fibrotic remodeling. interaction between miR-34a-5p checked dual luciferase assay. the effects...
Objectives To evaluate whether the serum sodium concentration is associated with progression and long-term prognosis of Chinese HIV/AIDS patients. Methods Three hundred eighty seven hospitalized patients were recruited into this retrospective cohort study. The strata moderate/severe hyponatremia, mild hyponatremia normonatremia. Disease was estimated using CD4 counts WHO clinical stage. Correlation analysis used to disease progression. Kaplan-Meier method Cox proportional hazards model...
Abstract Background: Previous studies have examined the bulk transcriptome of peripheral blood immune cells in acquired immunodeficiency syndrome patients experiencing immunological non-responsiveness. This study aimed to investigate characteristics specific cell subtypes who exhibit Methods: A single-cell sequencing mononuclear obtained from both responders (IRs) (CD4 + T-cell count >500) and non-responders (INRs) <300) was conducted. The transcriptomic profiles were used identify...
The prevalence of HIV/AIDS and tuberculosis (TB) within mainland China is unprecedented the convergence these two infectious diseases increasingly significantly endangering human health for socioeconomic development. To date, clinical manifestations, laboratory presentation, epidemiologic features HIV/TB coinfection cases in have not been described detail. assess incidence, characteristics outcome with HIV TB, we conducted a cross-sectional study coinfected reported from nine domestic...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has becoming globally public health threat. Recently studies were focus on SARS-CoV-2 RNA to design vaccine and drugs. It was demonstrated that virus could play as sponge host noncoding RNAs regulate cellular processes. Bioinformatic research predicted a series of motif genome where are targets human miRNAs. In this study, we used dual-luciferase reporter assays validate the interaction between 3'UTR S (S-3'UTR) gene bioinformatic...
<b><i>Background:</i></b> Effective antiretroviral therapy extends the survival of patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome, but these remain at higher risk for heart diseases compared general population. Previous studies have suggested that HIV-1 glycoprotein 120 (gp120) may be associated disease. However, underlying mechanisms by which gp120-mediated myocardial injury occurs unknown....
Soluble urokinase plasminogen activator receptor (suPAR) reflects the immune activation in circumstances of inflammation and infection. It has been considered as a risk biomarker associated with poor outcome various low-grade infectious diseases. The study is aimed at investigating whether suPAR predictive value short-term survival patients hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Serum expression was compared among different states chronic B virus Sixty HB-ACLF were...
In coronavirus disease 2019 (COVID-19) patients, interleukin (IL)-6 is one of the leading factors causing death through cytokine release syndrome. Hence, identification IL-6 downstream from clinical patients' transcriptome very valid for analyses its mechanism. However, study conditional and time consuming to collect optional size samples, as patients have heterogeneity. A possible solution deeply mine relative existing data. Several transcriptome-based studies on other diseases or...
This study aimed to investigate the epidemiology and etiological spectrums of BSI in Fujian over past 6 years post antiretroviral treatment (ART) era.A retrospective, observational was conducted include positive inpatients with HIV between September 2015 August 2021 Mengchao Hepatobiliary Hospital Medical University, largest designated HIV/AIDS care hospital Fujian, China. Demographic data laboratory including gender, age, blood cell counts, biochemistry results, CD4 CD8 HIV-RNA loads,...
Toll‑like receptor 2 (TLR2), is an important pattern recognition which serves a role in chronic inflammation of the liver. However, TLR2 progression human hepatocellular carcinoma (HCC) remains unknown. The aim present study was to examine effects activation signaling pathway on biological functions, such as proliferation and apoptosis. expression HCC tissues assayed by quantitative polymerase chain reaction, flow cytometry western blotting. B76/Huh7 cells were transfected with...
With the widespread use of integrase strand transfer inhibitors (INSTIs) in clinical setting, transmission INSTIs-resistance mutations may increase. Data regarding transmitted drug resistance (TDRM) to INSTIs Chinese HIV patients are limited. The aim this study was summarize TDRM, including frequency protease (PIs) and reverse transcriptase (RT) (RTIs) treatment-naïve Southeast China.HIV-1 positive were retrospectively selected between April 2018 October 2020 from Mengchao Hepatobiliary...
Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the interaction between host genetic factors and have revealed dozens of genes that impact diverse processes AIDS disease. To resolve more related AIDS, canonical correlation analysis was used determine restriction metabolic pathway gene expression. The results show HIV-1 postentry cellular viral cofactors from are coexpressed human transcriptome microarray datasets. Further,...
Acquired immune deficiency syndrome is a severe disease in humans caused by human immunodeficiency virus. Several genes were characterized as host genetic factors that impact the processes of AIDS disease. Recent studies on patients revealed series complicating with AIDS. To resolve gene interaction between and diseases, canonical correlation analysis was used to identify global other pathway expression. The results showed HLA-B, HLA-A, MH9, ZNED1, IRF1, TLR8, TSG101, NCOR2, GML are key...
Abstract In plasma, miR-34a could be one of potential biomarkers for frailty and is involved in the physiology processes which are benefit from exercise. One its targets, Smad4 play important role TGF-β1 pathway a dominant factor balancing collagen production degradation hepatic stellate cells. TGF-β1/Smad4 regulated deposition hallmark fibrosis. Thus, link between exercise disease. The regulation on by LncRNAs cells (HSCs) still reserved to revealed. current study, it was hypothesized that...