A5102961903- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- Fluoride Effects and Removal
- Hepatitis C virus research
- Bone and Dental Protein Studies
- Folate and B Vitamins Research
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Carcinogens and Genotoxicity Assessment
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Malaria Research and Control
- Pediatric health and respiratory diseases
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Microbial infections and disease research
- RNA modifications and cancer
Fujian Medical University
2006-2023
Education Department of Fujian Province
2007-2023
Gansu Provincial Center for Disease Control and Prevention
2016-2022
Fujian Institute of Microbiology
2022
National Center for AIDS/STD Control and Prevention,China CDC
2021
Guiyang Medical University
2018-2019
Center for Disease Control
2012-2014
Centers for Disease Control and Prevention
2010
An outbreak of polychlorinated biphenyl (PCB) poisoning from the consumption contaminated rice oil, covering four counties in central Taiwan, was investigated. There were 1843 cases by end 1980. The highest frequency incidence occurred during period March to July 1979. severity clinical manifestations varied. Most patients showed symptoms mild or moderate severity. major age group affected between 11 and 20 years old. victims students factory workers. amount PCB intake each victim estimated...
HIV subtypes convey important epidemiological information and possibly influence the rate of disease progression. In this study, progression in patients infected with CRF01_AE, CRF07_BC, subtype B was compared largest molecular epidemiology study ever done China. A national data set pol sequences assembled by pooling from public databases Beijing laboratory network. Logistic regression used to assess factors associated risk AIDS at diagnosis ([AIDSAD], defined as a CD4 count < 200 cells/µL)...
Abstract Chronic exposure to fluoride continues be a public health problem worldwide, affecting thousands of people. Fluoride can cause abnormal proliferation and activation osteoblast osteoclast, leading skeletal fluorosis that pain harm joints bones even lead permanent disability. Nevertheless, there is no recognized mechanism explain the bone lesions fluorosis. In this work, we performed population study in vitro experiments investigate pathogenic relation methylation promoter p16 . The...
The aim of this study was to investigate the shift in epidemiological features HIV/AIDS during last three decades Fujian Province, southeastern China, so as provide evidence for development novel control strategies.Data pertaining conventional surveillance, sentinel surveillance and survey Province period from 1987 2015 were collected. trends described, subtypes HIV strain genotyped. In addition, response antiretroviral therapy evaluated, genotypic resistance assayed.There an increasing...
This study aimed to investigate the epidemiological features of HIV-infected subjects co-infected with HBV/HCV in Fujian Province, southeastern China, and identify risk factors. Blood samples were collected from 2,028 HIV antibody-positive Province. Serum HBsAg anti-HCV antibody detected, CD4+ T cell count was measured. Of subjects, prevalence HIV-HBV, HIV-HCV, HIV-HBV-HCV co-infections 16.22%, 3.7%, 0.79%, respectively. Man (OR = 1.912, 95% CI: 1.371-2.667), key population 0.756,...
HIV/AIDS remains a global public health problem, and understanding the structure of social networks people living with is great importance to unravel HIV transmission, propose precision control reduce new infections. This study aimed investigate epidemiological characteristics transmission in Fujian province, southeastern China from 2015 2020 based on molecular network.Newly diagnosed, treatment-naive patients were randomly sampled province 2020. Plasma was for in-house genotyping resistance...
Abstract Background: Previous studies have examined the bulk transcriptome of peripheral blood immune cells in acquired immunodeficiency syndrome patients experiencing immunological non-responsiveness. This study aimed to investigate characteristics specific cell subtypes who exhibit Methods: A single-cell sequencing mononuclear obtained from both responders (IRs) (CD4 + T-cell count >500) and non-responders (INRs) <300) was conducted. The transcriptomic profiles were used identify...
Rabies is a global fatal infectious viral disease that characterized by high mortality after onset of clinical symptoms. Recently, there has been an increase in the incidence rabies China. The aim this study was to investigate human and characterize virus nucleoprotein gene dogs sampled from Fujian Province, Southeast China 2002 2012. Data pertaining cases Province during period through 2012 were collected, epidemiological profiles described. saliva brain specimens collected Quanzhou,...
Objective: To investigate the distribution of HIV-1 genetic subtypes and pretreatment drug resistance (PDR) among men who have sex with (MSM) from 19 cities 6 provinces in China. Methods: From April to November 2019, 574 plasma samples ART-naive infected MSM were collected Hebei, Shandong, Jiangsu, Zhejiang, Fujian, Guangdong provinces, total ribonucleic acid (RNA) was extracted amplified pol gene region by nested polymerase chain reaction (PCR) after reverse transcription. Then sequences...
BackgroundAt the end of 2009, a total 501 AIDS patients were receiving antiretroviral therapy (ART) in Fujian Province China, yet there no assessments to determine treatment efficacy and HIV-1 preventive potency under current health care delivery system. MethodsDuring period 2005–2009, we assessed outcomes initial ART by following up 381 for 12 months Province. CD4+ T-lymphocyte (CD4) count, plasma viral load (VL), patient characteristics analysed. The results compared between 4 groups...
To investigate the HIV-1 genotype and distribution of newly diagnosed cases in Fujian Province 2020, so as to provide insights into formulation precise AIDS control strategy province.
Objective To evaluate the survival capacity of Human Immunodeficiency virus (HIV) in microenvironment biological safety laboratory,and provide evidence for making disinfection and protective measures.Methods HIV-LWJ supernatant fluid samples were prepared suspended water or RPMI1640 medium containing 5％ serum.HIV suspension was exposed to 4 ℃,room temperature (20 ℃-25 ℃) 37 ℃,and smeared on surface sterilized metal slice,glass slice,plastics slice,paper slice fabric slice.Rinsing infecting...
Background One of the major characteristics human immunodeficiency virus type 1 (HIV-1) is its unusually high degree genetic variability, which involves in diagnosis, subtyping, vaccine design, and epidemiology. HIV-1 CRF01AE a main prevalent recombinant strain China. In this study, three full-length genomes from Fujian Province, China were cloned, sequenced, analyzed; further diversity defining epidemiologic analysis carried out. Methods Proviral DNA was extracted non-cultured peripheral...
Objective: To identify the influencing factors that leading to nonspecific responses indeterminate HIV antibody tests, provide scientific evidence for differential diagnosis of infection and control strategy. Methods: A case study was conducted. The samples in confirmed Western blot (WB) but were negative nucleic acid collected as group from WB results confirmatory laboratories Fujian province 2015-2016. general population matched with screening selected two compared groups by matching...
OBJECTIVE To characterize full length glycoprotein 120 gene variations of 21 HIV-1 CRF01_AE isolated in Fujian, China, so as to help the immunogenic research and vaccine design. METHODS Twenty-one peripheral blood samples were randomly collected form 100 HIV-1CRF01_AE infected persons Fujian 2004 approximately 2005. DNA was extracted, Nested-PCR used amplify envelop protein gp120 gene. The PVR products underwent Sepharose electrophoresis. Genotype identification done by BLAST program....