A5070906733- Arsenic contamination and mitigation
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Retinoids in leukemia and cellular processes
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- Polysaccharides and Plant Cell Walls
- Heart Failure Treatment and Management
- Hepatitis Viruses Studies and Epidemiology
- NF-κB Signaling Pathways
- Respiratory viral infections research
- Cardiac electrophysiology and arrhythmias
- Drug Transport and Resistance Mechanisms
- Acute Lymphoblastic Leukemia research
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Ginkgo biloba and Cashew Applications
- Sphingolipid Metabolism and Signaling
- Medicinal Plants and Bioactive Compounds
- Natural product bioactivities and synthesis
- Influenza Virus Research Studies
- Ion channel regulation and function
Guiyang Medical University
2015-2024
China Railway Corporation
2024
Guangdong Medical College
2022-2024
Jiangxi University of Traditional Chinese Medicine
2012-2024
Xi'an Shiyou University
2024
Beijing University of Posts and Telecommunications
2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Anhui Medical University
2010-2023
Anhui Medical University
2010-2023
Guangzhou Medical University
2022
Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral host genetic characteristics that may influence disease manifestations clinical management.In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV were enrolled at 28 hospitals across genotype interleukin 28B (IL28B) genotypes determined compared patient demographic parameters medical status.Among...
// Fei Luo 1, 2, * , Baofei Sun 3, Huiqiao Li 4, Yuan Xu 5 Yi Liu 2 Xinlu Lu Jun 3 Qingling Wang Shaofeng Wei Le Shi Xiaolin Qizhan Aihua Zhang 1 Institute of Toxicology, School Public Health, Nanjing Medical University, 211166, Jiangsu, People's Republic China The Key Laboratory Modern Ministry Education, Environmental Pollution Monitoring and Disease Control, Guiyang 550025, Guizhou, 4 Department Epidemiology Biostatistics, Thoracic GI Oncology Branch, Center for Cancer Research, National...
Abstract Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main damaging effects on public health. Exposure can cause hepatic fibrosis, but molecular mechanisms which this occurs are complex and elusive. It not known if miRNAs involved in arsenic‐induced liver fibrosis. We found that livers mice exposed arsenite, there were elevated levels microRNA‐21 (miR‐21), phosphorylated mammalian target rapamycin (p‐mTOR), arginase 1 (Arg1); low phosphatase tensin homolog...
EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, therapeutic options for sensitizing first TKIs and delaying emergence of mutant are limited. In this study, we show that quercetin directly binds glucose-6-phosphate dehydrogenase (G6PD) inhibits its enzymatic activity through competitively abrogating NADP+ binding catalytic domain. This inhibition subsequently reduces intracellular...
Context: Gardenia jasminoides J. Ellis (Rubiaceae) is a shrub tree species distributed all over the world. Now its pharmacological activities such as anti-atherosclerosis have been extensively studied.
A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated predictive value of qAnti-HBc in HBeAg-positive patients undergoing PEG-IFN therapy. total 140 who underwent therapy 48 weeks and follow-up 24 were enrolled this study. Serum samples taken every 12 post-treatment. The baseline response was evaluated. Patients divided into 2 groups according to...
Currently, most arsenic (As) studies in populations are concerned with water-borne arsenicosis. However, residents Xingren County of Guizhou Province, Southwest China, represent a unique case arsenicosis which is related to indoor combustion high As-containing coal. This study aimed assess the alterations As levels and its risk factors coal-borne during past 20 years. Four follow-up investigations were selected from year 1998 2017, total 245, 272, 584, 309 involved four investigations,...
Arsenic poisoning is a geochemical disease that seriously endangers human health. The liver one of the important target organs for arsenic poisoning, several studies have shown oxidative stress plays an role in arsenic-induced damage. However, specific mechanism has not yet been fully elucidated, and currently, there are no effective intervention measures prevention treatment In this study, effect Nrf2/GPX4 signaling pathway damage was first evaluated. results show can activate increase...
dietary fiber (ADF) contains 95% water-insoluble fiber, resulting in poor application performance. To address this issue, ADF was modified by four methods (cellulase, sodium hydroxide, high-temperature, and
Endemic arsenicosis is a public health problem that affects thousands of people worldwide.However, the biological mechanism involved not well characterized, and there no specific treatment.Exposure to arsenic may be associated with immune-related problems.In present work, we performed an investigation determine whether Th17/Treg balance was abnormal in peripheral blood mononuclear cells (PBMCs) patients caused by burning coal.Furthermore, investigated effect Ginkgo biloba extract (GBE) on...
Chronic arsenic exposure is a risk factor for human fatty liver disease, and the ERK signaling pathway plays an important role in regulation of lipid metabolism. However, whether progression arsenic-induced metabolism disorder specific mechanism remain unclear. Here, by constructing rat model induced chronic exposure, we demonstrated that might regulate disorders through PPAR pathway. Arsenic could upregulate expression PPARγ CD36 liver, decrease PPARα CPT-1 increase organ coefficient...
Abstract Chronic exposure to fluoride continues be a public health problem worldwide, affecting thousands of people. Fluoride can cause abnormal proliferation and activation osteoblast osteoclast, leading skeletal fluorosis that pain harm joints bones even lead permanent disability. Nevertheless, there is no recognized mechanism explain the bone lesions fluorosis. In this work, we performed population study in vitro experiments investigate pathogenic relation methylation promoter p16 . The...
Chronic exposure to inorganic arsenic is a major environmental public health issue worldwide affecting more than 220 million of people. Previous studies have shown the correlation between poisoning and cellular senescence; however, knowledge regarding mechanism effective prevention measures has not been fully studied. First, associations among ERK/CEBPB signaling pathway, oxidative stress, arsenic-induced skin cell senescence were confirmed using HaCaT model. In arsenic-exposed group,...
Long‐term arsenic (As) exposure can cause liver injury, hepatic cirrhosis, and cancer. Meanwhile, Dictyophora polysaccharides (DIP) have excellent antioxidation, anti‐inflammation, immune protection effects. There are currently few reports on the effects of DIP As‐induced hepatotoxicity its pharmacological value. Therefore, this study was aimed at elucidating exploring preventive role in antifibrosis. In our study, SD rat As poisoning model established by feeding method to explore influence...
The purpose of this study is to understand the mechanism sodium arsenite (NaAsO2)-induced apoptosis L-02 human hepatic cells, and how Dictyophora polysaccharide (DIP) protects cells from arsenic-induced apoptosis. results revealed that DIP pretreatment inhibited NaAsO2 induced by increasing anti-apoptotic Bcl-2 expression decreasing pro-apoptotic Bax expression. Proteomic analysis showed arsenic treatment disrupted metabolism associated proteins, including ribosomal proteins (RPs). After...
This study aimed to establish multivariate prediction models according a response-guided therapy (RGT) based strategy at baseline and week 12 24 of follow-up predict the functional cure for HBeAg-negative patients with chronic hepatitis B (CHB) treated pegylated interferonα (PEG-IFNα).A total 242 CHB were PEG-IFNα 52 weeks followed up weeks. Responses end (EOF) defined as surface antigen (HBsAg) loss, either responders or non-responders.The three most meaningful predictors an age ≤ 40 years,...