A5100661455- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Virus-based gene therapy research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- interferon and immune responses
- Immune Response and Inflammation
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- Galectins and Cancer Biology
Shandong Academy of Agricultural Sciences
2016-2025
First Affiliated Hospital Zhejiang University
2015-2024
Zhejiang University
2015-2024
National Clinical Research Center for Digestive Diseases
2022-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2012-2024
Southern Medical University
2013-2024
Ministry of Agriculture and Rural Affairs
2024
Hunan Agricultural University
2024
Zhujiang Hospital
2024
Ningbo University
2023-2024
Hemoglobin is released from lysed RBCs in numerous clinical settings. High mobility group box 1 (HMGB1) a nuclear and cytosolic DNA-binding protein injured cells that has been shown to play an important role inducing inflammation. Because both of these endogenous molecules are frequently present sites necrosis inflammation, we studied their interaction on the activation macrophages. We report this article hemoglobin HMGB1 synergize activate mouse macrophages release significantly increased...
Patients with acute-on-chronic liver failure (ACLF) represent a heterogeneous population. The aim of the study is to identify distinct groups according etiologies precipitating events. A total 405 ACLF patients were identified from 1,361 cirrhosis acute decompensation and categorized types insults. Clinical characteristics prognosis between hepatic group extrahepatic compared, performance prognostic models was tested in different groups. Two (hepatic-ACLF extrahepatic-ACLF) among...
MiR-199a-3p (miR-199a) can enhance the chemosensitivity of hepatocellular carcinoma (HCC). Because easy degradation miRNA by direct infusion, effective vehicle-mediated delivery miR-199a may represent a new strategy for improving HCC chemotherapy. Considering mesenchymal stem cell (MSC)-derived exosomes as promising natural nanovectors drug and molecule delivery, we aimed to determine whether from adipose tissue-derived MSCs (AMSCs) could be used deliver improve...
Exosomes are extracellular membrane vesicles of 50- to 130-nm diameter secreted by most tumor cells. can mediate the intercellular transfer proteins and RNAs, including microRNAs (miRNAs), promote both tumorigenesis premetastatic niche formation. In this study, we performed exosomal RNA sequencing identify candidate miRNAs that could be associated with colorectal cancer (CRC) its distant metastasis. The expression profiles miRNA, as isogenic human primary CRC cell line SW480 highly...
Acetaminophen (APAP)-induced liver injury (AILI) is a common disease in clinical practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI available clinics, but novel strategies are still needed due to complicated pathological changes and side effects NAC. Here, we found that astaxanthin (ASX) can prevent through Nrf2/HO-1 pathway. After with ASX, there was positive activation pathway models both vivo vitro accompanied by enhanced autophagy reduced...
IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor heterodimer IL-22RA1/CRF2-4. produced by T cells induces production of acute-phase reactants in vitro vivo, suggesting its involvement inflammation. Here we report identification a designated IL-22RA2 (IL-22 receptor-alpha 2) appears be naturally expressed soluble receptor. shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, CRF2-9) physically adjacent IL-20Ralpha...
Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection humans has not well characterized. In this study, we analysed frequency phenotypic characteristics of Tregs patients different virus (HBV) status, investigated effect on antiviral immune responses CHB patients, mechanism effect. A total 137 subjects, including 79...
Deficiency in autophagy, a lysosome-dependent cell degradation pathway, has been associated with variety of diseases especially cancer. Recently, the activation autophagy by hepatitis B virus X (HBx) protein, which is implicated (HBV)-associated hepatocellular carcinoma (HCC), identified hepatic cells. However, underlying mechanism and relevance HBx-activated to carcinogenesis caused HBV remain elusive. Here, transfection genomic DNA HBx hepatoma cells, we showed that HBV- or HBx-induced...
Chronic hepatitis B (CHB) is characterized by functionally impaired virus‐specific CD 8 + T ‐cell responses. However, the mechanism underlying this dysfunction has not been fully clarified. We examined role of a newly identified protein, immunoglobulin domain and mucin domain‐containing molecule‐3 ( im‐3), in regulating antiviral response CHB patients. im‐3 expression on peripheral cells from 20 patients healthy controls was determined flow cytometry. The phenotypes cytokine‐producing...
Chronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral host genetic characteristics that may influence disease manifestations clinical management.In this cross-sectional observational study, treatment-naïve Han ethnic adults with recently confirmed chronic HCV were enrolled at 28 hospitals across genotype interleukin 28B (IL28B) genotypes determined compared patient demographic parameters medical status.Among...
Purpose This paper aims to examine the effects of task and relationship conflicts on team creativity, moderating role shared leadership in inter-organizational teams. An normally comprises employees from collaborated organizations brought together conduct an initiative, such as product development. Practitioners researchers have witnessed prevalence conflict Despite significant scholarly investigation into importance a deep theoretical understanding framework remains elusive....
Background The COVID-19 pandemic continues to pose an international public health threat. Prevention is of paramount importance protect the high-risk group older adults until specific treatments for become available; however, little work has been done explore factors that promote preventive behaviors among this population. Objective This study aims investigate knowledge, perceived beliefs, and towards in China determine influence their practice behaviors. Methods From February 19 March 19,...
Human MxA, an interferon-inducible cytoplasmic dynamin-like GTPase, possesses antiviral activity against multiple RNA viruses. Recently, MxA has also been demonstrated to have the hepatitis B virus (HBV), a well-known DNA responsible for acute and chronic liver disease in humans. We investigated molecular mechanism anti-HBV of MxA. Our results that HepG2.2.15 cells, GTPase independently suppressed production surface antigen HBV without changing level core (HBcAg) distribution mRNA....
Background/Aims: To investigate the effects of emodin on concanavalin A (Con A)-induced hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: fulminant model was established successfully by intravenous administration Con (20 mg/kg) male Balb/c mice. Emodin administered gavage before after injection. The levels pro-inflammatory cytokines chemokines, numbers CD4+ F4/80+ cells infiltrated into liver, amounts phosphorylated p38 MAPK NF-γB mouse livers RAW264.7 EL4 were...
To explore the approaches and diagnostic yield of genetic testing for renal disease in children, we describe genotype phenotype national cohort children with from 13 different regions China recruited 2014 to 2018 by building up multicenter registration system (Chinese Children Genetic Kidney Disease Database, CCGKDD). diagnosis was confirmed 42.1% our 1001 pediatric patients clinical suspicion a disease. Of 106 distinct monogenetic disorders detected, 15 accounted 60.7% diagnoses. The 29.1%...
Abstract Background and Aims: Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role HBV infection humans has not well characterized. In this study, we analyzed the frequency cytokines secretion of circulating infected patients with different statuses, also evaluated potential association levels liver injury. Methods: The study population consisted 133 subjects, including 40 mild chronic hepatitis B (CHB) patients, 37 severe CHB 20 acute (AHB)...
The scaffold protein IQGAP1 shows elevated levels in several cancer types, but its expression hepatocellular carcinoma is unknown. We found that 58% of human tissue samples had increased compared to adjacent normal tissue. Overexpressing raised the vivo tumorigenicity cells, and forced overexpression vitro stimulated cell proliferation. Cell growth was reduced by knockdown or mutation IQGAP1, treatment cells with a phosphotidylinositol 3-kinase inhibitor. To determine mechanism which...
The aim of this study was to evaluate the prevalence PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) expression, and explore prognostic significance expression alone in combination with Ki67 p53 non-small-cell lung cancer (NSCLC).We detected 30 samples normal tissue, 32 lymph node metastases 279 primary cancers by immunohistochemistry, analysed correlation tumour tissues. results showed that higher (75%) than tumours (44.8%) tissues (0%). associated histological type,...
MicroRNAs, which regulate mRNAs, operate through a variety of signaling pathways to participate in the development colorectal cancer (CRC). In this study, we found that microRNA (miR)‐143‐3p expression was significantly lower both CRC and liver metastatic tissues from compared with normal colonic tissues. Functional assays showed miR‐143‐3p inhibited cell invasion migration vitro. Using bioinformatics approach, identified target mRNAs. Among candidate targets, only integrin alpha 6 ( ITGA6 )...