A5025145840- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- Cytokine Signaling Pathways and Interactions
- Veterinary Oncology Research
- Glioma Diagnosis and Treatment
- Dermatology and Skin Diseases
- Whipple's Disease and Interleukins
- IL-33, ST2, and ILC Pathways
- Photoacoustic and Ultrasonic Imaging
- Cutaneous Melanoma Detection and Management
- bioluminescence and chemiluminescence research
- Cancer, Stress, Anesthesia, and Immune Response
- Oral Health Pathology and Treatment
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Psoriasis: Treatment and Pathogenesis
- Click Chemistry and Applications
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Advanced Biosensing Techniques and Applications
- Head and Neck Cancer Studies
Blaze Bioscience (United States)
2014-2021
University of South Australia
2019
The University of Queensland
2019
Overlake Hospital Medical Center
2018
University of Washington Medical Center
2018
University of Washington
2018
Cedars-Sinai Medical Center
2014
Seattle University
2004
HistoGenetics (United States)
2001-2004
The proinflammatory cytokines IL-17A and IL-17F have a high degree of sequence similarity share many biological properties. Both been implicated as factors contributing to the progression inflammatory autoimmune diseases. Moreover, reagents that neutralize significantly ameliorate disease severity in several mouse models human disease. mediates its effects through interaction with cognate receptor, IL-17 receptor (IL-17RA). We report here IL-17RA-related molecule, IL-17RC is for IL-17F....
Cytokines that signal through Class II receptors form a distinct family includes the interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has defined cytokine subfamily AK155, IL-19, IL-20, IL-22, IL-24. Within this subfamily, IL-24 exhibit substantial sharing receptor complexes; all three are capable signaling IL-20RA/IL-20RB, IL-20 both can also use IL-22R/IL-20RB. However, biological effects these cytokines appear quite distinct: immune activity with...
Abstract Interleukin (IL)-21 was recently discovered using a functional cloning approach based on expression of its receptor. It is similar in domain organization and primary sequence to IL-2 IL-15. Like these cytokines, IL-21 uses the common γ chain IL-2/15 receptor, which forms heterodimeric receptor complex with IL-21R. produced by activated T cells, it influences proliferation B cells cytolytic activity natural killer cells. The elucidation unique biological effects represents an intense...
IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor heterodimer IL-22RA1/CRF2-4. produced by T cells induces production of acute-phase reactants in vitro vivo, suggesting its involvement inflammation. Here we report identification a designated IL-22RA2 (IL-22 receptor-alpha 2) appears be naturally expressed soluble receptor. shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, CRF2-9) physically adjacent IL-20Ralpha...
Object The intraoperative clear delineation between brain tumor and normal tissue in real time is required to ensure near-complete resection without damaging the nearby eloquent brain. Tumor Paint BLZ-100, a ligand chlorotoxin (CTX) conjugated indocyanine green (ICG), has shown potential be targeted contrast agent. There are many infrared imaging systems use, but they not optimized low concentration amount of ICG. authors present novel proof-of-concept near-infrared (NIR) system using...
Fluorescence-guided surgery (FGS) can improve extent of resection in gliomas. Tozuleristide (BLZ-100), a near-infrared imaging agent composed the peptide chlorotoxin and fluorophore indocyanine green, is candidate molecule for FGS glioma other tumor types.To perform phase 1 dose-escalation study to characterize safety, pharmacokinetics, fluorescence tozuleristide adults with suspected glioma.Patients received single intravenous dose 3 29 h before surgery. Fluorescence images cavity Situ...
Abstract There is a need in surgical oncology for contrast agents that can enable real-time intraoperative visualization of solid tumors complete resections while sparing normal surrounding tissues. The Tumor Paint agent BLZ-100 peptide–fluorophore conjugate specifically bind and fluoresce the near-infrared range, minimizing light scatter signal attenuation. In this study, we provide preclinical proof concept use imaging as administered before surgery to dogs with variety naturally occurring...
BLZ-100 is a single intravenous use, fluorescent imaging agent that labels tumor tissue to enable more complete and precise surgical resection. It composed of chlorotoxin peptide covalently bound the near-infrared fluorophore indocyanine green. in clinical development for intraoperative visualization human tumors. The nonclinical safety pharmacokinetic (PK) profile was evaluated mice, rats, canines, nonhuman primates (NHP). Single bolus administration well tolerated, no adverse changes were...
<h3>Importance</h3> Surgical cure of head and neck squamous cell carcinoma (HNSCC) remains hampered by inadequately resected tumors poor recognition lesions with malignant potential. BLZ-100 is a chlorotoxin-based, tumor-targeting agent that has not yet been studied in HNSCC. <h3>Objective</h3> To evaluate uptake models HNSCC oral dysplasia. <h3>Design, Setting, Participants</h3> This was an observational study (including sensitivity specificity analysis) orthotopic xenograft mouse model...
BLZ-100 (tozuleristide) is an intraoperative fluorescent imaging agent that selectively detects malignant tissue and can be used in real time to guide tumor resection. The purpose of this study was assess the safety, tolerability, pharmacokinetics explore pharmacodynamics fluorescence skin tumors. In first-in-human study, administered intravenously 21 adult patients 2 days before excising known or suspected cancers. Doses were 1, 3, 6, 12, 18 mg, with 3–6 patients/cohort. Fluorescence...
Context.— Resection of breast carcinoma with adequate margins reduces the risk local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection margin assessment. In this study, fluorescence imaging was conducted ex vivo on gross pathology specimens. Objectives.— To determine potential tozuleristide to detect fresh specimens feasibility fluorescence-guided assessment surgical margins. Design.—...
Objective: Intraoperatively delineating between normal tissue and tumorous in real time ensures near-complete tumor resection. Recently, this has been shown by using targeted fluorescent agents that bind to cells, conjugated a fluorophore can be detected with fluorescence imaging methods. One promising ligand for vivo is chlorotoxin (CTX), which indocyanine green (ICG), named BLZ-100. In conjunction BLZ-100, we are nearing completion of developing optimizing an system (SIRIS) in-vivo BLZ-100...
Abstract Tumor PaintTM technology is designed to provide real-time visualization of tumors during surgery at improved resolution over existing methods. BLZ-100 a Paint product consisting chlorotoxin (CTX) peptide conjugated near-infrared (NIR) fluorophore that being advanced toward clinical studies. CTX-based products have been shown illuminate broad range cancers in mouse models. To facilitate translation, preclinical feasibility study was conducted dogs with naturally occurring solid...
Complete initial resection can give cancer patients the best opportunity for long-term survival. There is unmet need in surgical oncology optical imaging that enables simple and precise visualization of tumors consistent contrast with surrounding normal tissues. Near-infrared (NIR) agents camera systems detect them represent an area active research development. The investigational Tumor Paint agent BLZ-100 a conjugate chlorotoxin peptide NIR dye indocyanine green (ICG) has been shown to...
Abstract Over 230,000 new breast cancer cases occur in the US annually. Complete surgical removal of tumor tissue is critical to reduce risk local recurrence. About 24% patients who undergo conservation surgery require a second due positive margins. Second surgeries can be psychologically and financially costly patients. BLZ-100, peptide-fluorophore conjugate, Tumor Paint product candidate being developed provide real-time, high resolution, intraoperative optical contrast between normal...
<p>ROI analysis of ex vivo and in situ tumor normal tissues.</p>