A5086715649- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Trace Elements in Health
- Cancer Research and Treatments
- Electrochemical Analysis and Applications
- Environmental Toxicology and Ecotoxicology
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Systemic Lupus Erythematosus Research
- Radioactive element chemistry and processing
- Hepatitis C virus research
- Photodynamic Therapy Research Studies
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Porphyrin Metabolism and Disorders
- Software Engineering Research
- Cancer Treatment and Pharmacology
- Free Radicals and Antioxidants
- Multiple Myeloma Research and Treatments
- bioluminescence and chemiluminescence research
- Cutaneous Melanoma Detection and Management
- Peptidase Inhibition and Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Immunotherapy and Immune Responses
Blaze Bioscience (United States)
2015-2021
University of South Australia
2019
The University of Queensland
2019
University of Washington
1991-2018
Overlake Hospital Medical Center
2018
University of Washington Medical Center
2018
Bristol-Myers Squibb (United States)
2012
Seagen (United States)
2004-2006
Cleveland Clinic
1994-2005
Cornell University
2005
Ceruloplasmin (CP) was found to inhibit xanthine oxidase and ferritin-dependent peroxidation of phospholipid liposomes, as evidenced by decreased malondialdehyde formation.Ceruloplasmin also shown superoxide-mediated mobilization iron from ferritin, in a concentration-dependent manner, measured spectrophotometrically using the iron(I1) chelator bathophenanthroline sulfonate.Ceruloplasmin failed function peroxyl radical-scavenging antioxidant its inability free radical-initiated linoleic...
Fluorescence-guided surgery (FGS) can improve extent of resection in gliomas. Tozuleristide (BLZ-100), a near-infrared imaging agent composed the peptide chlorotoxin and fluorophore indocyanine green, is candidate molecule for FGS glioma other tumor types.To perform phase 1 dose-escalation study to characterize safety, pharmacokinetics, fluorescence tozuleristide adults with suspected glioma.Patients received single intravenous dose 3 29 h before surgery. Fluorescence images cavity Situ...
Abstract Mercuric ion, a well‐known nephrotoxin, promotes oxidative tissue damage to kidney cells. One principal toxic action of Hg(II) is the disruption mitochondrial functions, although exact significance this effect with regard toxicity poorly understood. In studies effects on superoxide (O ) and hydrogen peroxide (H 2 O production by rat mitochondria, (1–6 μM), in presence antimycin A, caused concentration‐dependent increase (up fivefold) H but an apparent decrease production. also...
Interferon lambdas (IFN-lambda) are Type III interferons with biological activity, including induction of antiviral genes, similar to I IFNs, but signal through a distinct receptor complex. The expression pattern for the IFN-lambda is more cell specific than widely distributed IFN-alpha receptor, suggesting in vivo, may have fewer side effects IFN-alpha, such as less hematologic toxicities. A PEGylated form (PEG-rIL-29) was well tolerated animals and did not result toxicity. Clinical data...
BLZ-100 is a single intravenous use, fluorescent imaging agent that labels tumor tissue to enable more complete and precise surgical resection. It composed of chlorotoxin peptide covalently bound the near-infrared fluorophore indocyanine green. in clinical development for intraoperative visualization human tumors. The nonclinical safety pharmacokinetic (PK) profile was evaluated mice, rats, canines, nonhuman primates (NHP). Single bolus administration well tolerated, no adverse changes were...
A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation a rat model of arthritis without steroid toxicity.
BLZ-100 (tozuleristide) is an intraoperative fluorescent imaging agent that selectively detects malignant tissue and can be used in real time to guide tumor resection. The purpose of this study was assess the safety, tolerability, pharmacokinetics explore pharmacodynamics fluorescence skin tumors. In first-in-human study, administered intravenously 21 adult patients 2 days before excising known or suspected cancers. Doses were 1, 3, 6, 12, 18 mg, with 3–6 patients/cohort. Fluorescence...
Context.— Resection of breast carcinoma with adequate margins reduces the risk local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection margin assessment. In this study, fluorescence imaging was conducted ex vivo on gross pathology specimens. Objectives.— To determine potential tozuleristide to detect fresh specimens feasibility fluorescence-guided assessment surgical margins. Design.—...
Ceruloplasmin (CP) effectively inhibited superoxide and ferritin-dependent peroxidation of phospholipid liposomes, using xanthine oxidase or gamma irradiation water as sources superoxide. In addition, CP superoxide-dependent mobilization iron from ferritin. suggesting that lipid by decreasing the availability also exhibited some scavenging activity evidenced its inhibition cytochrome c reduction. However, did not quantitatively account for inhibitory effects on release. The iron-catalyzed in...
Abstract The effects of transition metals on nonenzymatic and ceruloplasmin catalyzed epinephrine oxidation were investigated by studying rates in purified buffers the presence metal chelating agents. We found that does not “autoxidize” sodium chloride solutions prepared with deionized water was further chromatography over Chelex 100 resin prior to use. Epinephrine oxidized rapidly tap (1.20±0.12 nmoles/min) or (0.40±0.80 nmoles/min), but this prevented addition Desferal, a potent agent....
Interleukin-21 (IL-21), a pleiotropic immunostimulatory type I cytokine, has anticancer effects in animal models. Preclinical studies designed to assess the safety of recombinant human IL-21 (rIL-21) for use phase oncology are described. The rIL-21 (≤3.0 mg/kg per dose) was given intravenously cynomolgus monkeys ( Macaca fascicularis) once daily 5 days, followed by 9 nondosing days (1 cycle) ≤4 cycles. pharmacokinetics dose-dependent. Accumulation not observed after repeated dosing,...