A5102905617- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Bacterial Genetics and Biotechnology
- Physics of Superconductivity and Magnetism
- Quantum and electron transport phenomena
- Protein Structure and Dynamics
- Superconducting and THz Device Technology
- Topological Materials and Phenomena
- Protein Hydrolysis and Bioactive Peptides
- Animal Disease Management and Epidemiology
- Mast cells and histamine
- Advanced Thermoelectric Materials and Devices
- Drug-Induced Hepatotoxicity and Protection
- Reproductive Biology and Fertility
- Dermatology and Skin Diseases
- Antibiotic Resistance in Bacteria
- Drug Transport and Resistance Mechanisms
- Child Development and Digital Technology
- Renal and related cancers
- Probiotics and Fermented Foods
- Surface and Thin Film Phenomena
- Medical Imaging and Pathology Studies
- Nitric Oxide and Endothelin Effects
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
University of Manchester
2024
University of Pennsylvania
2024
Seagen (United States)
2024
Purdue University West Lafayette
2022
Novartis (United States)
2021
Novartis (Switzerland)
2021
University of Iowa Hospitals and Clinics
2021
Fred Hutch Cancer Center
2020
University of Utah
2019
University of California, San Francisco
2015
Extensive efforts have been undertaken to combine superconductivity and the quantum Hall effect so that Cooper-pair transport between superconducting electrodes in Josephson junctions is mediated by one-dimensional edge states. This interest has motivated prospects of finding new physics, including topologically-protected quasiparticles, but also extends into metrology device applications. So far it proven challenging achieve detectable supercurrents through conductors. Here we show domain...
A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation a rat model of arthritis without steroid toxicity.
The impenetrability of the blood-brain barrier (BBB) to most conventional drugs impedes treatment central nervous system (CNS) disorders. Interventions for diseases like brain cancer, neurodegeneration, or age-associated inflammatory processes require varied approaches CNS drug delivery. Cystine-dense peptides (CDPs) have drawn recent interest as drug-delivery vehicles. Found throughout phylogenetic tree, often in drug-like roles, their size, stability, and protein interaction capabilities...
Information on the long-term treatment satisfaction with secukinumab for patients plaque psoriasis in real-world settings is limited. The objective of this study was to describe who initiated using data from an electronic medical records-based dermatology database. Patients aged ≥ 18 years Modernizing Medicine Data Services' affiliate's database received 3/1/2018-1/21/2020 were included. Satisfaction treatment's effectiveness clearing skin evaluated a 5-point Likert scale during 12-month...
Chronic wasting disease (CWD) is a highly infectious, fatal prion that affects cervid species. One promising method for CWD surveillance the use of detection dog–handler teams wherein dogs are trained on volatile organic compound signature fecal matter. However, using matter from CWD-positive deer poses biohazard risk; prions can bind to soil particles and remain infectious in contaminated areas extended periods time, it very difficult decontaminate affected areas. solution noninfectious...
Despite extensive preclinical testing, cancer therapeutics can result in unanticipated toxicity to non-tumor tissue patients. These toxicities may pass undetected experiments due modeling limitations involving poor biomimicry of 2-dimensional vitro cell cultures and lack interspecies translatability vivo studies. Instead, primary cells be grown into miniature 3-dimensional structures that recapitulate morphological functional aspects native tissue, termed "organoids." Here, human...
The rapid development of infrared spectroscopy, observational astronomy, and scanning near-field microscopy has been enabled by the emergence sensitive mid- far-infrared photodetectors. Owing to their exceptional signal-to-noise ratio fast photoresponse, superconducting hot-electron bolometers (HEBs) have become a critical component in these applications. While HEBs are traditionally made from sputtered thin films like Nb or NbN, potential layered van der Waals (vdW) superconductors is...
FGF21, an important metabolic regulator, has recently been suggested as a biomarker for heart failure (HF). FGF21 is involved in the integrated mitochondrial stress response, and shown to be upregulated with DNA damage, which occurs more frequently dilated cardiomyopathy. In this study, we investigated whether can used HF. We collected blood cardiac tissue samples from ischemic non-ischemic HF patients who have undergone VAD transplantation. also mice due 1) combination of transverse aortic...