A5073278624- Asthma and respiratory diseases
- Inflammatory Bowel Disease
- Microscopic Colitis
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- HIV Research and Treatment
- Nutrition, Genetics, and Disease
- Gene expression and cancer classification
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Digestive system and related health
- Single-cell and spatial transcriptomics
- Biosimilars and Bioanalytical Methods
- Advanced Breast Cancer Therapies
- Scientific Computing and Data Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Galectins and Cancer Biology
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Pregnancy-related medical research
- Autoimmune and Inflammatory Disorders Research
Incyte (United States)
2022-2024
Lung Institute
2023
Cedars-Sinai Medical Center
2023
Wilmington University
2002-2023
Cytobank (United States)
2018-2019
Vala Sciences (United States)
2017
Indiana University
2015
Prometheus Biosciences (United States)
2014-2015
University of California, San Francisco
2008-2014
University of Michigan
2009
Polymorphism in the genes for cytochrome (CYP)2C9 and vitamin K epoxide reductase complex subunit 1 (VKORC1) affect pharmacokinetics pharmacodynamics of warfarin. We developed validated a warfarin-dosing algorithm multi-ethnic population that predicts best dose stable anticoagulation, compared its performance against other regression equations.We determined allele haplotype frequencies CYP2C9 VKORC1 on 167 Caucasian, African-American, Asian Hispanic patients On subset where complete data...
Abstract Epithelial plasticity has been suggested in lungs of mice following genetic depletion stem cells but is unknown physiological relevance. Viral infection and chronic lung disease share similar pathological features cell loss alveoli, basal (BC) hyperplasia small airways, innate immune activation, that contribute to epithelial remodeling function. We show a subset distal airway secretory cells, intralobar serous (IS) are activated assume BC fates influenza virus infection....
Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential mesenchymal stromal cells (MSCs), significant heterogeneity and lack critical quality attributes (CQAs) based on capacity likely have contributed to inconsistent clinical outcomes. This exists not only between MSC lots derived from different donors, tissues manufacturing conditions, but also within given lot in form functional subpopulations. We therefore explored functionally relevant morphological...
Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to post-acute sequelae of SARS-CoV-2 (PASC) that persist for weeks years following initial viral infection. Clinical manifestations PASC are heterogeneous and often involve multiple organs. While many hypotheses have been made on the mechanisms its associated symptoms, biological drivers still unknown. We enrolled 494 patients with COVID-19 at their presentation a hospital or clinic followed them...
CDK2 is a critical regulator of the cell cycle. For variety human cancers, dysregulation CDK2/cyclin E1 can lead to tumor growth and proliferation. Historically, early efforts develop inhibitors with clinical applications proved unsuccessful due challenges in achieving selectivity over off-target CDK isoforms associated toxicity. In this report, we describe discovery (4-pyrazolyl)-2-aminopyrimidines as potent class that display CDKs 1, 4, 6, 7, 9. SAR studies led identification compound 17,...
Even with effective viral control, HIV-infected individuals are at a higher risk for morbidities associated older age than the general population, and these serious non-AIDS events (SNAEs) track plasma inflammatory coagulation markers. The cell subsets driving inflammation in aviremic HIV infection not yet elucidated. Also, whether ART-suppressed causes premature induction of found uninfected elderly or if novel network ensues when co-exist is unclear. In this study we measured combinational...
Background The understanding of Post-acute sequelae SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment symptoms encompassing the acute illness period. To gain insight into various disease trajectories PASC, we assessed symptom evolution and clinical factors associated with development PASC over 3 months, starting Methods We conducted a prospective cohort study to identify parameters PASC. performed cluster case control analyses data, including symptomatology collected...
We sought to better understand the immune response during immediate post-diagnosis phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by identifying molecular associations with longitudinal disease outcomes. Multi-omic analyses identified differences in cell composition, cytokine levels, and subset-specific transcriptomic epigenomic signatures between individuals on a more serious trajectory (Progressors) as compared those milder course (Non-progressors). Higher levels...
A series of exceptionally selective CDK2 inhibitors are described. Starting from an HTS hit, we successfully scaffold hopped to a 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one core structure, which imparted promising initial selectivity within the CDK family. Extensive further SAR identified additional factors that drove above 200× for CDKs 1/4/6/7/9. General kinome was also greatly improved. Finally, use in vivo metabolite identification allowed us pinpoint sulfonamide dealkylation as...
BackgroundThe issue of overdiagnosis in low-dose computed tomography (LDCT) screening trials could be addressed by the development complementary biomarkers able to improve detection aggressive disease. The mutation profile LDCT screening–detected lung tumors is currently unknown.MethodsTargeted next-generation sequencing was performed on 94 tumors. Associations with clinicopathologic features, survival, and risk a plasma microRNA signature classifier were analyzed.ResultsThe mutational...
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a rapid response scientific community further understand and combat its associated pathologic etiology. A focal point been on immune responses mounted during post-acute phases of infection, but immediate post-diagnosis phase remains relatively understudied. We sought better collecting blood from study participants soon after positive test identifying molecular associations with longitudinal...