A5101543254- Reliability and Agreement in Measurement
- Hemodynamic Monitoring and Therapy
- Amino Acid Enzymes and Metabolism
- Multi-Criteria Decision Making
- Drug Transport and Resistance Mechanisms
- Statistical Methods in Clinical Trials
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Radio Frequency Integrated Circuit Design
- Metabolism, Diabetes, and Cancer
- Hemostasis and retained surgical items
- Pancreatic function and diabetes
- Advanced Statistical Methods and Models
- Semiconductor Quantum Structures and Devices
- Advanced Semiconductor Detectors and Materials
- Neuroendocrine Tumor Research Advances
- Surgical Sutures and Adhesives
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Optical Sensing Technologies
- Optimal Experimental Design Methods
- Cancer Genomics and Diagnostics
- Head and Neck Anomalies
- Chronic Kidney Disease and Diabetes
Children's Hospital of Philadelphia
2021
Creative Commons
2021
University of California, San Francisco
2013-2020
Powerchip (Taiwan)
2017
The University of Texas MD Anderson Cancer Center
2017
University of Illinois Chicago
2007-2015
Carnegie Mellon University
2014
ABS Consulting (United States)
2014
Baxter (United States)
1990-2013
California State University, Fullerton
2012
Measurements of agreement are needed to assess the acceptability a new or generic process, methodology, and formulation in areas laboratory performance, instrument assay validation, method comparisons, statistical process control, goodness fit, individual bioequivalence. In all these areas, one needs measurements that capture large proportion data within meaningful boundary from target values. Target values can be considered random (measured with error) fixed (known), depending on situation....
Despite having high-resolution structures for eukaryotic large ribosomal subunits, it remained unclear how these ribonucleoprotein complexes are constructed in living cells. Nevertheless, knowing where proteins interact with RNA (rRNA) provides a strategic platform to investigate the connection between spatial and temporal aspects of 60S subunit biogenesis. We previously found that function individual yeast (RPLs) precursor rRNA (pre-rRNA) processing correlates their location structure...
This paper proposes several Concordance Correlation Coefficient (CCC) indices to measure the agreement among k raters, with each rater having multiple (m) readings from of n subjects for continuous and categorical data. In addition, normal data, this also coverage probability (CP) total deviation index (TDI). Those are used intra, inter all raters. Intra-rater same rater. Inter-rater different raters based on average readings. Total-rater individual addition agreement, assess inter,...
Free flap reconstruction of the head and neck is routinely performed with success rates around 94% to 99% at most institutions. Despite experience meticulous technique, there a small but recognized risk partial or total loss in postoperative setting. Historically, microvascular surgeons involve resident house staff monitoring protocols, programs relied heavily on in-house physicians assure timely intervention for compromised flaps. In 2003, Accreditation Council Graduate Medical Education...
Background: Surgical hemostasis is achieved using adjunctive hemostats when conventional methods fail. Objective: This study compares the effectiveness of two gelatin-thrombin hemostats. Hypothesis: To determine effectiveness, were compared in vivo, vitro, and scanning electron microscopy (SEM). Methods: In a heparinized porcine liver abrasion model was used to compare hemostatic success, degree bleeding, blood loss at 2, 5, 10 minutes post-treatment. thrombin supernatant each hemostat Red...
Microporous Polysaccharide Hemospheres (MPH) are a new plant-derived polysaccharide powder hemostat. Previous studies investigated MPH as replacement to nonflowable hemostatic agents of different application techniques (e.g., oxidized cellulose, collagen); therefore, the purpose this study was determine if is surrogate for flowable similar handling and techniques, specifically thrombin-gelatin matrix.Hemostatic efficacy compared using heparinized porcine abrasion model mimicking capsular...
Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed numerous other diseases. However, its mechanism of action in the liver has yet to be characterized systematic manner. To comprehensively identify genes regulatory elements associated with metformin treatment, we carried out RNA-seq ChIP-seq (H3K27ac, H3K27me3) on primary human hepatocytes from same donor treated vehicle control, or compound C, an AMP-activated protein kinase (AMPK) inhibitor (allowing...
The goal of pharmacogenomics research is to discover genetic polymorphisms that underlie variation in drug response. Increasingly, involves large numbers patients and the application new technologies methodologies enable discovery. Pharmacogenomics Research Network (PGRN) has become a community‐driven network investigators spanning scientific clinical disciplines. Here, we highlight activities types resources PGRN members enhance drive basic translational pharmacogenomics.
This paper is an overview that summarizes recently developed tools in assessing agreement for methods comparison and instrument/assay validation medical devices. emphasizes concept, sample sizes, examples more than analytical formulas. We have considered a unified approach of evaluating among multiple instruments (k), each with replicates (m) both continuous categorical data. start the basic scenario two (k = 2), only one measurement (m 1). In this data, we also consider if target values are...
Objective: The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as targeted chemotherapeutic. Different particle coatings were employed assess their impact on cellular uptake in vitro. In vivo then performed demonstrate efficacy tumor-bearing mouse models.Materials method: Paclitaxel nanosuspensions prepared using homogenization process coated with excipients. Surface charge measured by zeta potential, potency high-performance liquid...
Human organic anion transporters (OATPs) are vital for the uptake and efflux of drugs endogenous compounds. Current identification inhibitors these is based on experimental screening. Virtual screening remains a challenge due to lack three-dimensional protein structures. Here, we describe workflow identify OATP2B1 transporter in DrugBank library over 5,000 druglike molecules. OATP member 2B1 highly expressed intestine, where it participates oral absorption drugs. Predictions from Random...
Abstract Aging is a time‐dependent complex biological phenomenon observed in various organs and organelles of all living organisms. To understand the molecular mechanism age‐associated functional loss aging kidneys, we have analyzed expression proteins kidneys young (19–22 wk) old (24 months) C57/BL6 male mice using 2‐DE followed by LC‐MS/MS. We found that levels 49 were upregulated ( p ≤ 0.05), while only ten downregulated 0.05) due to aging. The identified belong three broad categories:...
Ankyloglossia, or tongue-tie, is characterized by a short thickened lingual frenulum; this can be associated with impaired breastfeeding, speech, and dentofacial growth. The indications for performing frenotomy, frenuloplasty, other operative interventions are unclear.A meta-analysis was performed to identify the extent of benefit from frenotomy in breastfeeding measures, degree maternal pain during feeding randomized controlled trials. A structured literature review analyzed optimal type...
Hyaluronan (HA) is a glycosaminoglycan found in connective tissues and tissue spaces, including the peritoneal cavity. In vivo studies rat model of dialysis (PD) have shown that addition HA to PD solution during an intraperitoneal dwell can alter fluid transport protect membrane from effects inflammation repeated infusions solution. The current study sought evaluate safety its effect on solute when administered humans.13 patients were enrolled prospective, randomized crossover involving...