A5057093655- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Urinary and Genital Oncology Studies
- Adipose Tissue and Metabolism
- Genomics and Chromatin Dynamics
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Misinformation and Its Impacts
- Vaccine Coverage and Hesitancy
- Genomic variations and chromosomal abnormalities
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Pharmacogenetics and Drug Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Sanofi (United States)
2020-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2009-2020
Pfizer (United States)
2019
United States Military Academy
2010-2015
Rosetta Stone (United States)
2007-2013
Columbia University
2012
Merck (Japan)
2010
Royal College of Surgeons in Ireland
2004
University of Pennsylvania
2004
Mercer (Czechia)
1998
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes in turn induce changes higher-order disease traits. Therefore, identifying the vary response DNA and also associate traits has potential provide functional information required only identify validate susceptibility genes affected by DNA, understand networks which such operate how these Toward end, we profiled more than 39,000 transcripts...
Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and metabolic processes. Despite rapid progress the understanding of these enzymes, a systematic investigation full spectrum functionality individual P450s, interrelationship or networks connecting them, genetic control each gene/enzyme is lacking. To this end, we genotyped, expression-profiled, measured P450 activities 466 human liver samples applied systems biology approach via integration genetics, gene...
Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation genes two neurodegenerative diseases, late‐onset Alzheimer's disease ( AD ) Huntington's HD ). We identified networks differentially co‐expressed DC gene pairs that either gained or lost correlation cases relative to control group, with former dominant for both patterns replicating independent human cohorts...
Genome-wide association studies (GWAS) have demonstrated the ability to identify strongest causal common variants in complex human diseases. However, date, massive data generated from GWAS not been maximally explored true associations that fail meet stringent level of required achieve genome-wide significance. Genetics gene expression (GGE) shown promise towards identifying DNA variations associated with disease and providing a path functionally characterize findings GWAS. Here, we present...
To map the genetics of gene expression in metabolically relevant tissues and investigate diversity SNPs (eSNPs) multiple from same individual, we collected four approximately 1000 patients undergoing Roux-en-Y gastric bypass (RYGB) clinical traits associated with their weight loss co-morbidities. We then performed high-throughput genotyping profiling carried out a genome-wide association analyses for more than 100,000 representing tissues: liver, omental adipose, subcutaneous stomach....
Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus several metabolic tissues, resulting in an energy imbalance systems level.To provide inter-tissue view of obesity with respect molecular states are associated physiological states, we developed framework for constructing tissue-to-tissue coexpression networks between genes hypothalamus, liver or adipose tissue. These have scale-free...
Background In hepatocellular carcinoma (HCC) genes predictive of survival have been found in both adjacent normal (AN) and tumor (TU) tissues. The relationships between these two sets the general process tumorigenesis disease progression remains unclear. Methodology/Principal Findings Here we investigated HCC by comparing gene expression, DNA copy number variation using ∼250 AN TU samples representing, respectively, pre-cancer state, result tumorigenesis. Genes that participate were defined...
Abstract Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated several glycemic and metabolic traits genome-wide association studies (GWAS). Here, we demonstrate that humans, alleles are increased expression subcutaneous adipose tissue (SAT) an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio fasting levels, but lower body fat). In human adipocyte models, knockdown of preadipocytes accelerates differentiation. mice, Fam13a...
Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed numerous other diseases. However, its mechanism of action in the liver has yet to be characterized systematic manner. To comprehensively identify genes regulatory elements associated with metformin treatment, we carried out RNA-seq ChIP-seq (H3K27ac, H3K27me3) on primary human hepatocytes from same donor treated vehicle control, or compound C, an AMP-activated protein kinase (AMPK) inhibitor (allowing...
To identify the genes and pathways that underlie cardiovascular metabolic phenotypes we performed an integrated analysis of a mouse C57BL/6J x A/J F2 (B6AF2) cross by relating genome-wide gene expression data from adipose, kidney, liver tissues to physiological endpoints measured in population. We have identified large number trait QTLs including loci driving variation cardiac function on chromosomes 2 6 hotspot for adiposity, energy metabolism, glucose traits chromosome 8. Integration...
Expression quantitative trait locus (eQTL) studies in human liver are crucial for elucidating how genetic variation influences variability disease risk and therapeutic outcomes may help guide strategies to obtain maximal efficacy safety of clinical interventions. Associations between expression microarray genome-wide genotype data from four eQTL (n = 1,183) were analyzed. More than 2.3 million cis-eQTLs 15,668 genes identified. When eQTLs filtered against a list 1,496 drug response genes,...
Vesicoureteric reflux (VUR) is the retrograde flow of urine from bladder into ureters. It most common urological anomaly in children, and a major cause end-stage renal failure hypertension both children adults. VUR seen approximately 1-2% Caucasian newborns frequently familial.In order to search for genetic loci involved VUR, we performed genome-wide linkage scan using 4710 single-nucleotide polymorphisms (SNPs) 609 individuals 129 Irish families with >1 affected member.Nonparametric (NPL)...