A5074057226- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Chemical Reactions and Isotopes
- Computational Drug Discovery Methods
- Immune cells in cancer
- Cell Image Analysis Techniques
- Biosimilars and Bioanalytical Methods
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Advanced Biosensing Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- Cellular Mechanics and Interactions
- Genetic Associations and Epidemiology
Presage Biosciences (United States)
2022-2024
Imperial College London
2018
Sage Bionetworks
2011-2017
AstraZeneca (United Kingdom)
2013
Sorbonne Paris Cité
2013
Koo Foundation Sun Yat-Sen Cancer Center
2013
Université Paris Cité
2013
Inserm
2013
Framingham Heart Study
2013
National Heart Lung and Blood Institute
2013
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes in turn induce changes higher-order disease traits. Therefore, identifying the vary response DNA and also associate traits has potential provide functional information required only identify validate susceptibility genes affected by DNA, understand networks which such operate how these Toward end, we profiled more than 39,000 transcripts...
The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not other members, Rac Rho. This interaction dependent on presence G protein-binding domain. Cellular expression epitope-tagged WASP produces clusters are highly enriched polymerized actin. clustering observed with C-terminally deleted inhibited by coexpression...
IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis multiple autoimmune diseases. IL-17RA ubiquitously expressed receptor essential for biologic activity. Despite widespread expression, activity most classically defined its ability to induce expression cytokines, chemokines, and other mediators stromal cells. The lack responsiveness mouse genetically deficient poorly complemented human IL-17RA, suggesting...
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown. The objectives of this study were to discover genetic variants affecting gene expression in human lung tissue, refine susceptibility for asthma GWAS studies, and use genetics network analyses find key drivers asthma. We performed a genome-wide search quantitative trait (eQTL) 1,111 samples. eQTL...
Sulforaphane, a natural compound identified by drug repurposing, reduces hepatic glucose production and improves control in type 2 diabetes.
Cognitive impairment occurs in one-third of patients with Duchenne muscular dystrophy, a lethal X-linked, recessive disease caused by mutations the dystrophin gene which is expressed both brain and muscle, two transcripts having alternative first exons. Previous reports have indicated that 'brain-type' transcript predominates brain. Using situ hybridisation antisense oligonucleotides, expression four distinct mRNAs specific areas demonstrated here; 14 kb muscle-type brain-type were found to...
Cylindromatosis (CYLD) is a deubiquitinating enzyme that altered in patients with familial cylindromatosis, condition characterized by numerous benign adnexal tumors. However, the regulatory function of CYLD remains unsettled. Here we show development B cells, T and myeloid cells was unaffected CYLD-deficient mice, but activation these mediators innate adaptive immunity resulted enhanced NF-κB JNK activity associated increased TNF receptor–associated factor 2 (TRAF2) essential modulator...
Dendritic cells (DCs) are a phenotypically and functionally heterogenous population of leukocytes with distinct subsets serving different set specialized immune functions. Here we applied an in vitro whole cell panning approach using antibody phage display technology to identify cell-surface epitopes specifically expressed on human blood BDCA3(+) DCs. A single-chain fragment (anti-1F12 scFv) was isolated that recognizes conserved surface antigen both DCs mouse CD8alpha(+) We demonstrate...
Objective— Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene–disease associations, however, remain unclear. We hypothesized that genetic variants both strong and subtle effects drive gene subnetworks in turn affect CHD. Approach Results— surveyed CHD-associated interactions by constructing coexpression networks using whole blood expression profiles from 188 cases age- sex-matched controls. Twenty-four...
Journal Article WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia Get access Jonathan M.J. Derry, Derry 1Howard Hughes Medical InstituteStanford, CA 94305 Search for other works by this author on: Oxford Academic PubMed Google Scholar Julie A. Kerns, Kerns Kenneth I. Weinberg, Weinberg 3Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los AngelesLos Angeles, 90027 Hans D. Ochs, Ochs 4Department Pediatrics, University Washington...
Using cDNA selection with a YAC from the Xp11.2 region, we have identified novel gene (RBM3) that encodes polypeptide high sequence similarity to group of proteins bind RNA. On contig map, RBM3 is located between OATL1 and GATA1/TFE3 in sub-band Xp11.23, gives rise alternatively spliced transcripts variety human tissues. The longest open reading frame 157 amino acid protein predicted molecular weight 17 kDa. Its putative RNA-binding domain most closely resembles two previously characterized...
Background In hepatocellular carcinoma (HCC) genes predictive of survival have been found in both adjacent normal (AN) and tumor (TU) tissues. The relationships between these two sets the general process tumorigenesis disease progression remains unclear. Methodology/Principal Findings Here we investigated HCC by comparing gene expression, DNA copy number variation using ∼250 AN TU samples representing, respectively, pre-cancer state, result tumorigenesis. Genes that participate were defined...
The inability to identify the molecular causes of disease has led a disappointing rate development new medicines.By combining power community-based modeling with broad access large datasets on platform that promotes reproducible analyses, we can work toward more predictive maps deliver better therapeutics. A understanding is neededDrugs continue fail in clinical at startlingly high despite unprecedented amounts investment research and development, largely as result lack efficacy phase 2...
ABSTRACT Over 100 genetic loci harbor schizophrenia associated variants, yet how these common variants confer risk is uncertain. The CommonMind Consortium has sequenced dorsolateral prefrontal cortex RNA from cases (n=258) and control subjects (n=279), creating the largest publicly available resource to date of gene expression its regulation; ∼5 times larger than latest release GTEx. Using this resource, we find that ∼20% have could explain regulation brain expression. In five loci, modulate...
Signaling through the receptor activator of nuclear factor κB (RANK) is required for both osteoclast differentiation and mammary gland development, yet extent to which RANK utilizes similar signaling pathways in these tissues remains unclear. Mice expressing a kinase-inactive form inhibitor kinase α (IKKα) have defects those RANK-null mice apparently normal function. Because that completely lack IKKα severe skin skeletal are not associated with IKKα-kinase activity, we wished directly...