A5019109963- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- CAR-T cell therapy research
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS drug development and treatment
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
Huashan Hospital
2015-2024
Fudan University
2015-2024
Shanghai Public Health Clinical Center
2014-2024
National Institute for Communicable Disease Control and Prevention
2022-2024
Zhujiang Hospital
2009-2024
Southern Medical University
2006-2024
Nanfang Hospital
2006-2024
Shanghai Medical College of Fudan University
2013-2023
Yale University
2020
Wenzhou Medical University
2016
Lung injury, whether induced by infection or caustic chemicals, initiates a series of complex wound-healing responses. If uncontrolled, these responses may lead to fibrotic lung diseases and loss function. Thus, resolution injury must be tightly regulated. The key regulatory proteins required for controlling the have yet identified. Here we show that deubiquitinase CYLD led development fibrosis in mice after with Streptococcus pneumoniae. inhibited transforming growth factor-β-signalling...
This study aimed to observe the efficacy of corticosteroids in non-severe COVID-19 pneumonia. A retrospective based on propensity score matching was designed explore effects corticosteroids. Primary outcomes included rate patients who developed severe disease and mortality. Secondary duration fever, virus clearance time, length hospital stay, use antibiotics. total 475 with pneumonia were enrolled, 55 received early, low-dose, short-term therapy, 420 non-corticosteroids therapy. Compared...
Molecular targeted drugs and chimeric antigen receptor (CAR) T cell therapy represent specific biological treatments that have significantly improved the efficacy of treating hematologic malignancies. However, they face challenges such as drug resistance recurrence after treatment. Combining molecular CAR-T cells could regulate immunity, improve tumor microenvironment (TME), promote apoptosis, enhance sensitivity to killing. This approach might provide a dual coordinated attack on cancer...
The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG islands, and minichromosome structure epigenetically regulated methylation. However, regulatory effect each island methylation on activity remains elusive. In present study, we analyzed distribution within in patient samples investigated impact...
Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are known to play a critical role in impairing antiviral responses, viral factors responsible for expansion of MDSCs chronic (CHB) remain obscure. In order elucidate mechanism monocytic (mMDSCs) and function suppression during persistent HBV infection, we analyzed circulation frequency mMDSCs 164 CHB patients 70 healthy...
Although increasing evidence suggests the presence of extracellular HBV RNA species, their origin and molecular forms are still under debate. In addition to infectious virions, is known secrete several species incomplete viral particles, including hepatitis B surface antigen (HBsAg) naked capsids, empty during its replication cycle. Here, we demonstrated that RNAs were associated with capsids virions in HepAD38 cells. Interestingly, found unenveloped circulate blood patients form CACs and,...
Abstract Background Patients with relapsed/refractory acute myeloid leukaemia (AML) FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have limited treatment options and poor prognosis. Therefore, novel modalities are needed. Since high expression of natural killer group 2 member D ligands (NKG2DLs) can be induced by FLT3 inhibitors, we constructed dual-target single-chain fragment variable (scFv)/NKG2D-chimeric antigen receptor (CAR) T cells, explored whether inhibitors...
The gamma-glutamyl-transpeptidase to platelet ratio (GPR) is a new liver fibrosis model, which reported be more accurate than aspartate transaminase (AST) index (APRI) and based on the four factors (Fib-4) for diagnosing significant cirrhosis in patients with chronic hepatitis B (CHB) West Africa. aim of this study assess diagnostic accuracy GPR Chinese CHB patients, explore whether deserves popularized China. A total 372 who underwent biopsies routine laboratory tests were retrospectively...
DNA methylation is being increasingly recognized to play a role in regulation of hepatitis B virus (HBV) gene expression. The aim this study was compare the CpG island distribution among different HBV genotypes. We analyzed 176 full-length genomic sequences obtained from GenBank database, belonging genotypes A through J, identify islands genomes. Our results showed that while 79 out contained three conventional (I-III) as previously described, 83 harbored only two known islands. Novel were...
The hepatitis B viral X protein (HBx) has been established to implicate in the development of HBV-related hepatocellular carcinoma (HCC) via multiple pathways. oncoprotein astrocyte elevated gene-1 (AEG-1) is overexpressed various tumors, including HCC, and plays critical roles promoting cell migration invasion. However, mechanisms for AEG-1 upregulation tumors are largely unknown. In this study, we found that HBx could elevate level without altering its mRNA level. When blocking expression...
To evaluate the performance of aspartate transaminase-to-platelet ratio index (APRI) and fibrosis based on four factors (FIB-4) to predict significant cirrhosis in hepatitis B virus e antigen (HBeAg)-negative chronic (CHB) patients with alanine transaminase (ALT) ≤ twice upper limit normal (2 ULN). Histologic laboratory data 236 HBeAg-negative CHB ALT 2 ULN were analyzed. Predicted stage, established scales cut-offs for APRI FIB-4, was compared METAVIR scores obtained from liver biopsy. In...
Summary The gamma‐glutamyl transpeptidase‐to‐platelet ratio ( GPR ) is a new serum diagnostic model, which reported to be more accurate than aspartate transaminase‐to‐platelet index APRI and fibrosis based on the four factors (Fib‐4) for diagnosis of significant cirrhosis in chronic HBV infection CHBVI patients West Africa. To evaluate performance model liver HB eAg‐positive with high DNA (≥5 log 10 copies/mL) normal or mildly elevated alanine transaminase ALT (≤2 times upper limit ULN ))...
Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are not free from significant hepatic lesions. Recently, there has been an improved understanding of the clinical significance quantitative core antibody (qAnti-HBc) during CHB management. In this cross-sectional study, we evaluated utility qAnti-HBc in identifying liver inflammation patients.A total 469 (training set, n = 363; validation 106) who underwent biopsy (LB) were included. The quantified and...
The gamma-glutamyl transpeptidase-to-platelet ratio (GPR) is a novel serum model, which was reported more accurate than aspartate transaminase-to-platelet index (APRI) and fibrosis based on four factors (FIB-4) for diagnosing significant cirrhosis in HBV mono-infection West Africa. We aimed to evaluate the diagnostic performance of GPR liver patients with chronic hepatitis B (CHB) non-alcoholic fatty disease (NAFLD).Of 131 patients, 41 (31.3%), 20 (15.3%), 10 (7.6%) were classified as having...
Abstract During March 2022 to January 2023, two Omicron waves hit Shanghai and caused a massive number of reinfections. To better understand the incidence clinical characteristics SARS‐CoV‐2 reinfection in Shanghai, China, we conducted multicenter cohort study. COVID‐19 patients first infected with BA.2 (March 1, 2022–May 23, 2022) who were quarantined Huashan Hospital, Renji Jing'an Central Hospital followed up for from June 31, 2023. Of 897 primary infections, 148 (16.5%) experienced...
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Abstract Inflammation is a hallmark of many important human diseases. Appropriate inflammation critical for host defense; however, an overactive response detrimental to the host. Thus, must be tightly regulated. The molecular mechanisms underlying tight regulation remain largely unknown. Ecotropic viral integration site 1 (EVI1), proto-oncogene and zinc finger transcription factor, plays roles in normal development leukemogenesis. However, its role regulating NF-κB–dependent remains In this...
To examine the clinical features and risk factors for adverse outcomes in chronic hepatitis B (CHB) superimposed with E virus (HEV).
The pathogenesis of liver in patients with hepatitis B virus-associated acute chronic failure (HBV-ACLF) remains largely unknown. We aimed to elucidate the molecular mechanism underlying HBV-ACLF by using multiple approaches including transcriptome analysis. performed transcriptomic sequencing analysis on (n = 6), cirrhosis 6) and normal control 5), then explored potential specimen from another 48 subjects further validated cellular mechanisms THP-1 cells. RNA-sequencing data indicated that,...
Limited research has been conducted on healthcare-associated infective endocarditis (HAIE), although it is of increasing importance. The aim this study to compare the epidemiology, clinical characteristics, and prognosis community-acquired IE (CA-IE) with HAIE non-nosocomial (NNHCA-IE). A retrospective, consecutive case-series analysis was organized performed during 20-year period in Huashan Hospital, Shanghai, China. total 154 patients were enrolled, including 126 (81.8%) who had CA-IE 28...