A5018304938- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Pickering emulsions and particle stabilization
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
- Black Holes and Theoretical Physics
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Immune Response and Inflammation
- Healthcare professionals’ stress and burnout
- Advanced Cellulose Research Studies
- Photodynamic Therapy Research Studies
- Cosmology and Gravitation Theories
- Lignin and Wood Chemistry
- Proteins in Food Systems
- Ubiquitin and proteasome pathways
- Food Chemistry and Fat Analysis
Zhejiang University
2025
Stomatology Hospital
2018-2025
Huashan Hospital
2015-2024
Fudan University
2015-2024
Northeast Forestry University
2021-2024
Shanghai University of Electric Power
2024
Fudan University Shanghai Cancer Center
2018-2024
Shanghai Medical College of Fudan University
2024
Guangxi Transportation Research Institute
2024
National Institute for Communicable Disease Control and Prevention
2023-2024
We consider the problem of exact integration $T\bar{T}$-deformation two dimensional quantum field theories, as well some higher extensions in form $\det T$-deformations. When action can be shown to only depend algebraically on background metric solution deformation equation Lagrangian given closed terms solutions (extended) Burgers' equation. present such examples and dimensions.
FBP1, fructose-1,6-bisphosphatase-1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to 6-phosphate and inorganic phosphate. The mechanism that it functions antagonize glycolysis was epigenetically inactivated through NF-kappaB pathway in gastric cancer has been reported. However, its role liver carcinogenesis still remains unknown. Here, we investigated expression DNA methylation FBP1 primary HCC colon tumor. lowly expressed 80% (8/10) human...
Abstract The identification of serum biomarkers to improve the diagnosis and prognosis hepatocellular carcinoma has been elusive date. In this study, we took a mass spectroscopic approach characterize metabolic features liver in patients discover more sensitive specific for progression. Global profiling 50 pairs matched tissue samples from was performed. A series 62 metabolites were found be altered significantly tumors; however, levels acetylcarnitine correlated most strongly with tumor...
Abstract COVID-19 caused by a novel coronavirus SARS-CoV-2 emerged in Wuhan, Hubei province since December 2019, and rapid outbreak throughout China globally. Cities outside are also facing great challenge require implementing of effective feasible strategy precision diagnosing pneumonia (NCP). We described multicenter prospective study on diagnostic suspected NCP patients from January 22 nd to February 9 th , 2020 Eastern cities. Nasopharyngeal swabs were collected the patients. The...
In this study, a reactive oxygen species (ROS)-responsive nanoparticle system was designed for combining photodynamic therapy (PDT) and chemotherapy oral tongue squamous cell carcinoma (OTSCC)-targeted treatment. A PEGlated prodrug (RPTD) of doxorubicin (DOX) via thioketal linkage cRGD peptide modification synthesized then used to prepare nanoparticles encapsulating photosensitizer hematoporphyrin (HP). Thus, the obtained HP-loaded RPTD (RPTD/HP) had regular spherical shape small size,...
Summary Virus‐like particles encapsulating HBV‐RNA represent a serum biomarker for assessing viral replication activity in clinical practice. However, baseline levels of and their associations with replicative intermediates liver disease phases chronic hepatitis B remain unknown. In this cross‐sectional study, 102 patients were categorized into immune‐tolerant (IT), HBeAg‐positive immune active (HBeAg+IA), inactive carrier (IC) HBeAg‐negative (HBeAg‐IA) phases. samples 66 paired biopsies...
Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are known to play a critical role in impairing antiviral responses, viral factors responsible for expansion of MDSCs chronic (CHB) remain obscure. In order elucidate mechanism monocytic (mMDSCs) and function suppression during persistent HBV infection, we analyzed circulation frequency mMDSCs 164 CHB patients 70 healthy...
Purpose . Plasmacytoma variant translocation 1 (PVT1) is a long noncoding RNA encoded by the human PVT1 gene, which has been verified to mediate tumorigenesis in gastric cancer. However, underlying molecular mechanisms of cancer (GC) remain largely unknown. Methods The tumorigenic ability was subcutaneous and orthotopic mouse models. Flow cytometry assay TdT-mediated dUTP Nick-End Labeling staining were conducted explore effects on cell apoptosis. We investigated relative gene protein that...
Overexpression of Flap endonuclease 1 (FEN1) has been previously implicated in hepatocellular carcinoma (HCC), while its expression features and mechanisms remain unclear.In the current study, differential genes (DEGs) were screened HCC tissues normal liver 4 Gene Expression Omnibus (GEO) datasets.FEN1, one hub co-overexpressed genes, was further determined overexpressed TCGA, local cohorts, hepatocarcinogenesis model.In addition, high FEN1 indicated poor prognosis patients.Loss-of-function...
Abstract Immunoglobulin G4-related sialadenitis (IgG4-RS) is an immune-mediated fibro-inflammatory disease and the pathogenesis still not fully understood. The aim of this study was to explore role mechanism interleukin-13 (IL-13) in cellular senescence during progress IgG4-RS. We found that expression IL-13 receptor α1 (IL-13Rα1) as well number senescent cells were significantly higher submandibular glands (SMGs) IgG4-RS patients. directly induced shown by elevated activity...
Purpose: N6-methyladenosine (m 6 A) RNA methylation has been implicated in various malignancies. This study aimed to identify the m A regulator-based prognostic signature for hepatocellular carcinoma (HCC) as well provide candidate targets HCC treatment. Methods: The least absolute shrinkage and selection operator (LASSO) analyses were performed a risk Cancer Genome Atlas (TCGA) datasets. was further validated International Consortium (ICGC) Pan-Cancer Analysis of Whole Genomes (PCAWG)...
Abstract Background DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mechanisms of PRIM1 and identify it potential molecular target for HCC. Methods Hub genes were screened between HCC tissues normal liver 3 gene expression omnibus (GEO) datasets the genome atlas (TCGA). The features prognostic value one hub analyzed by bioinformatic...
Spherical lignin nanoparticles (SLNs) are able to formulate Pickering emulsions with various applications. However, SLN-stabilized commonly comprise droplets in the micron range, resulting inevitable instability upon storage. Herein, nonadsorbing cellulose nanofibrils (CNF) shown induce stabilization of diluted via concentration-dependent depletion effects. Two regimes for such interactions established, including flocculation-induced droplet aggregation at intermediate CNF concentrations and...
The bonding joints of 2219 aluminum alloy with different deformations 30%, 45% and 55% were fabricated using hot-compression bonding, subsequent subjected to homogenization treatment. interfacial microstructure oxide evolution the systematically investigated. results showed that increasing deformation can effectively reduce formation voids promote grain boundary migration (IGBM). As increased from 30% 55%, flat interface transformed into curved boundaries, ultimately being occupied by...
Abstract B- and T-lymphocyte attenuator (BTLA) levels are increased in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This condition is characterized by susceptibility to infection T-cell immune exhaustion. However, whether BTLA can induce exhaustion increase the risk of remains unclear. Here, we report that significantly circulating intrahepatic CD4 + T cells from HBV-ACLF, positively correlated disease severity, prognosis, complications. were upregulated...
Mesoscale building blocks are instrumental in bridging multilevel hierarchical mineralization, endowing macroscale entities with remarkable functionality and mechanical properties. However, the mechanism orchestrating homogeneous morphology of mesoscale mineralized motifs collagen-based hard tissues remains unknown. Here, utilizing avian tendons as a mineralization model, we reveal robust correlation between spherules presence phosvitin. By designing phosvitin-stabilized biomineral cluster...
We compared hepatic and serum lipid changes in hepatocellular carcinoma (HCC) patients to have a better understanding of the molecular pathogenesis this disease discovery novel biomarkers. Hepatic profiling was conducted paired liver samples from 50 HCC 24 healthy controls. A total 20 40 signatures were identified, yet there hardly any significant correlation between them. The results indicated that triglycerides phosphatidylcholines contributed significantly altered lipids, whereas...
Background/Aims: To investigate the role of selected serum microRNA (miRNA) levels as potential noninvasive biomarkers for differentiating S0-S2 (early fibrosis) from S3-S4 (late in patients with a chronic hepatitis B virus (HBV) infection.Methods: One hundred twenty-three treatmentnaive HBV infection who underwent liver biopsy were enrolled this study.The miRNAs measured using real-time quantitative polymerase chain reaction assay.A logistic regression analysis was performed to assess...