A5027946778- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Hepatitis C virus research
- COVID-19 diagnosis using AI
- Clostridium difficile and Clostridium perfringens research
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Streptococcal Infections and Treatments
- Long-Term Effects of COVID-19
- Immune responses and vaccinations
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 detection and testing
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Herpesvirus Infections and Treatments
- Diabetes and associated disorders
- COVID-19 and Mental Health
Shanghai Ninth People's Hospital
2022-2024
Shanghai Jiao Tong University
2022
Zhejiang Provincial People's Hospital
2019-2021
Hangzhou Medical College
2020-2021
Weatherford College
2021
Huashan Hospital
2016-2017
Fudan University
2016-2017
First Affiliated Hospital of Zhengzhou University
2014
Shanghai has been experiencing the Omicron wave since March 2022. Though several studies have evaluated risk factors of severe infections, analyses BA.2 infection and protective among geriatric people were much limited. This multicentre cohort study described clinical characteristics, assessed for infections. A total 1377 patients older than 60 enrolled, with 75.96% having comorbidities. The median viral shedding time hospitalization nine eight days, respectively. Severe critical associated...
Background/Aims: To investigate the role of selected serum microRNA (miRNA) levels as potential noninvasive biomarkers for differentiating S0-S2 (early fibrosis) from S3-S4 (late in patients with a chronic hepatitis B virus (HBV) infection.Methods: One hundred twenty-three treatmentnaive HBV infection who underwent liver biopsy were enrolled this study.The miRNAs measured using real-time quantitative polymerase chain reaction assay.A logistic regression analysis was performed to assess...
BACKGROUND The introduction of pegaspargase has greatly advanced the treatment acute lymphoblastic leukemia (ALL). In literature, only one case pegaspargase-induced multiple organ failure been reported, and patient died due to failure. CASE SUMMARY Herein, we present a rare 40-year-old man with ALL who developed after pegaspargase. had two phenomena reflecting poor prognosis, including discrepancy between clinical manifestations liver function persistently low alpha-fetoprotein (AFP) levels...
Abstract Based on molecular profiling, several prognostic markers for HCC are also used in clinic, but only a few genes have been identified as useful. We collected 72 post-operative liver cancer tissue samples. Genes expression were tested by RT-PCR. Multilayer perceptron and discriminant analysis built their ability to predict the prognosis of patients tested. Receiver operating characteristic (ROC) was performed multivariate with Cox’s Proportional Hazard Model confirming...
Dual oxidase 1 (DUOX1), which is the main source of reactive oxygen species (ROS) production in airway, can be silenced human lung cancer and hepatocellular carcinomas. However, prognostic value DUOX1 expression carcinoma patients still unclear. We investigated liver patients. mRNA was determined tumor tissues non-tumor by real‑time PCR. For evaluation expression, Kaplan-Meier method Cox's proportional hazards model (univariate analysis multivariate analysis) were employed. A simple risk...
The aim of this cohort study was to determine the characteristics and clinical outcome 287 patients with drug-induced liver injury (DILI) in a Chinese hospital. Between January 2008 2013, individuals who were diagnosed DILI selected. complete medical records each case reviewed, factors for extracted analyzed using univariate multivariate analysis. Two hundred eighty-seven cases identified as included study. A total 105 different drugs considered be related hepatotoxicity. main causative...
The Omicron variant is characterized by striking infectivity and antibody evasion. analysis of BA.2 infection risk factors limited among geriatric individuals understanding these would promote improvement in the public health system reduction mortality. Therefore, our research investigated for discriminating severe/critical from mild/moderate patients. Baseline characteristics enrolled patients (aged over 60 years) with infections were analyzed. A logistic regression was conducted to...
We determined the association between various clinical parameters and significant liver necroinflammation in patients with chronic hepatitis B (CHB) related cirrhosis. Two hundred CHB cirrhosis were recruited final analysis. Clinical laboratory values characteristics obtained from medical record. performed analyses of relationships independent variables by using binary logistic regression analysis discriminant Significant (grade≥2) was found 58.0% (80/138) antiviral therapy 48.4% (30/62) non...
Early determination of coronavirus disease 2019 (COVID-19) pneumonia from numerous suspected cases is critical for the early isolation and treatment patients.The purpose study was to develop validate a rapid screening model predict COVID-19 using random forest algorithm in China.A total 914 initially multiple centers were prospectively included. The computer-assisted embedding method used screen variables. adopted build based on training set. evaluated by confusion matrix receiver operating...
Acute liver failure (ALF) is a complex syndrome characterized by overactivation of innate immunity, and the recruitment differentiation immune cells at inflammatory sites. The present study aimed to explore role microRNA (miRNA/miR)‑21 its potential mechanisms underlying responses in ALF. Baseline serum miR‑21 was analyzed patients with ALF healthy controls. In addition, antagomir injected via tail vein into C57BL/6 mice, lipopolysaccharide/D‑galactosamine (LPS/GalN) mice after 48 h....
Abstract Novel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this from huge numbers suspects gives clinicians a big challenge. The aim the study was to develop rapid screening model for early predicting NCP Zhejiang population, as well its utility areas. A total 880 participants who were initially suspected January 17 February 19 included. Potential predictors selected via stepwise logistic regression analysis. established based on...
Objective To observe the effect of prednisolone combined with antiviral therapy on patients early severe hepatitis B.Methods Sixty cases B were randomly divided into treatment group and control group(30 cases).Patients in given conventional medical anti-virus telbivudine,while 30 mg addition to group,when TBIL decreased one half,prednisolone was reduced by 5 every week until withdraw; Serum biochemical values changes,adverse reactions complications two groups observed before after...
Objective To study interleukin-23 (IL-23) levels in serum and dendritic cells of acute-on-chronic liver failure (ACLF) patients with chronic hepatitis B (CHB) to explore its relationship the prognosis. Methods Peripheral blood mononuclear were collected from 40 ACLF CHB (including survival group 27 cases non-survival 13 cases) 26 healthy controls. Monocytes induced immature cell vitro TNF-α was added induce maturation. IL-23 mRNA detected by real time polymerase chain reaction (PCR),...
Liver cirrhosis is often considered as the final stage in development of liver diseases. However, effective etiological treatment can change its pathological state and even reverse. The most common cause China infection hepatitis virus. review focuses on changes fibrosis degree patients with HBV-related after long-term antiviral agents, such entecavir tenofovir. Key words: Liver cirrhosis; Antiviral therapy; Regression
Objective To assess the clinical characteristics and prognostic factors of bacterial liver abscess in patients with or without diabetes mellitus, to provide guides for diagnosis treatment. Methods A total 208 were enrolled during January 2014 2018 Zhejiang Provincial People’s Hospital, including 67 mellitus 141 mellitus. Clinical characteristics, laboratory examinntion, imaging findings, etiology results, treatment prognosis analyzed. Multiple logistic regression analysis was...
Abstract Novel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this from huge numbers suspects gives clinicians a big challenge. The aim the study was to develop rapid screening model for early predicting NCP Zhejiang population, as well its utility areas. A total 880 participants who were initially suspected Jan 17 Feb 19 included. Potential predictors selected via stepwise logistic regression analysis. established based on...