A5102859168- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Endometriosis Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Renal Transplantation Outcomes and Treatments
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Chemotherapy-induced organ toxicity mitigation
- Hedgehog Signaling Pathway Studies
- Oral and gingival health research
- HIV Research and Treatment
- Genital Health and Disease
- Peripheral Neuropathies and Disorders
- Ferroptosis and cancer prognosis
Southern Medical University
2025
Nanfang Hospital
2025
Peking Union Medical College Hospital
1990-2024
Hangzhou Medical College
2023-2024
Zhejiang Provincial People's Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Sun Yat-sen University
2024
Huashan Hospital
2013-2023
Fudan University
2011-2023
Klinikum rechts der Isar
2020-2021
Abstract Background The recent identification of a novel coronavirus, also known as severe acute respiratory syndrome coronavirus 2, has caused global outbreak illnesses. rapidly developing pandemic posed great challenges to diagnosis this infection. However, little is about the metatranscriptomic characteristics patients with disease 2019 (COVID-19). Methods We analyzed metatranscriptomics in 187 (62 cases COVID-19 and 125 non–COVID-19 pneumonia). Transcriptional aspects 3 core elements,...
Abstract COVID-19 caused by a novel coronavirus SARS-CoV-2 emerged in Wuhan, Hubei province since December 2019, and rapid outbreak throughout China globally. Cities outside are also facing great challenge require implementing of effective feasible strategy precision diagnosing pneumonia (NCP). We described multicenter prospective study on diagnostic suspected NCP patients from January 22 nd to February 9 th , 2020 Eastern cities. Nasopharyngeal swabs were collected the patients. The...
Summary Virus‐like particles encapsulating HBV‐RNA represent a serum biomarker for assessing viral replication activity in clinical practice. However, baseline levels of and their associations with replicative intermediates liver disease phases chronic hepatitis B remain unknown. In this cross‐sectional study, 102 patients were categorized into immune‐tolerant (IT), HBeAg‐positive immune active (HBeAg+IA), inactive carrier (IC) HBeAg‐negative (HBeAg‐IA) phases. samples 66 paired biopsies...
Nucleos(t)ide analogues rarely result in a durable off-treatment response chronic hepatitis B infection, whereas pegylated interferon (Peg-IFN) induces long-lasting only subset of patients. We assessed the effect sequential combination therapy with Peg-IFN-α2a and entecavir e antigen (HBeAg)-positive patients prior long-term investigated predictors to treatment. HBeAg-positive individuals who did not achieve HBeAg seroconversion during previous therapy, receiving added ongoing (sequential...
Preeclampsia (PE) is a syndrome exclusive to pregnancy, presenting substantial risks maternal and fetal health. Systemic immune-inflammatory response prominent feature of PE. A retrospective study was conducted involving 749 pregnant women in Guangzhou, China from September 2018 2024. Three hundred seventy participants were diagnosed with PE, 166 which had adverse pregnancy outcomes (APOs). Immuno-inflammatory markers expressed peripheral blood evaluated during the second-trimester. APOs...
Critically ill patients with coronavirus diseases 2019 (COVID-19) are of grave concern. Those usually underwent a stage excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit when used in early phase inflammation, namely, therapeutic window. Among Shanghai cohort and validation cohort, enrolled COVID-19 showing marked radiographic progression. Short-term, were...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly worldwide. This study is the first report tolerability, safety, pharmacokinetics (PK), and immunogenicity of a recombinant human anti-SARS-CoV-2 monoclonal antibody, etesevimab (CB6, JS016, LY3832479, or LY-CoV016), in healthy adults. paper describes randomized, double-blind, placebo-controlled, phase 1 study. A total 40 participants were enrolled receive single intravenous dose either placebo one four...
Reduced endometrium thickness and receptivity are two important reasons for recurrent implantation failure (RIF). In order to elucidate differences between these types of endometrial defects in terms molecular signatures, cellular interactions, structural changes, we systematically investigated the single-cell transcriptomic atlas across three distinct groups: RIF patients with thin (≤ 6 mm, TE-RIF), normal (≥ 8 NE-RIF), fertile individuals (Control).
INTRODUCTION: Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic venous malformation (VM) disease. The characteristic gastrointestinal (GI) bleeding from multiple VM lesions causes severe chronic anemia which renders most patients depend on lifelong blood transfusion and frequent endoscopic treatment with dismayed outcomes. Although recent case reports suggest that oral sirolimus (rapamycin) effective, comprehensive evaluation of its efficacy safety in need. METHODS: A prospective...
The aim of this study was to determine the effect bicyclol against cisplatin-induced hepatotoxicity and influence on antitumour capacity cisplatin in hepatocarcinoma 22 (H22) tumour-bearing mice. ICR mice were treated with (250 mg/kg, orally) 2 hr before injection (5 intraperitoneally) for 5 days (once daily) after H22 tumour cells implanted. All animals killed fifth day treatment weight each animal measured. Liver pathological changes examined by light microscopy biochemical assay....
Summary Background & Aims The strategies of adding on or switching to peginterferon (PEG‐IFN) improved the serological response rates in patients with chronic hepatitis B (CHB) who had previously experienced treatment nucleos(t)ide analogues. However, robust data which combination strategy is more effective remain lacking. Methods In this multicentre, parallel, open‐label, randomised, controlled trial, HBeAg‐positive CHB were treated entecavir ≥2 years, and surface antigen (HBsAg)...
Although long-term antiviral treatment with nucleos(t)ide analogs (NAs) can lead to histological improvement in patients chronic hepatitis B (CHB), a substantial proportion of still fail achieve regression fibrosis. Here, we investigated whether peginterferon alpha (Peg-IFNα） add-on therapy had benefits on fibrosis sustained severe even after NA treatment. We conducted retrospective analysis data from 50 CHB receiving 48 weeks Peg-IFNα therapy. All enrolled advanced or cirrhosis (S score ≥...
Abstract Background Chronic hepatitis B is usually treated with nucleos(t)ide analogues (NAs). However, a cure rarely achieved, even years of treatment. Here, we investigated whether viral replication completely halted and how long covalently closed circular DNA (cccDNA) persists in patients successfully NAs. Methods A series longitudinal serum samples collection cross-sectional liver biopsies were obtained from Viral variants HBV RNA enumerated by deep sequencing. intermediates hepatocytes...