A5037050291- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Traditional Chinese Medicine Studies
- Immune cells in cancer
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Liver physiology and pathology
- Catalytic C–H Functionalization Methods
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Cancer Mechanisms and Therapy
- Catalytic Alkyne Reactions
- Pediatric Hepatobiliary Diseases and Treatments
- interferon and immune responses
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Ginseng Biological Effects and Applications
Shuguang Hospital
2016-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Integrated Chinese Medicine (China)
2022-2024
National Institute for Communicable Disease Control and Prevention
2023-2024
Shanghai University
2013-2024
Shanghai Traditional Chinese Medicine Hospital
2013-2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Shanghai Institute of Hematology
2022
Zhejiang University
2018-2021
Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is among the deadliest malignancies. Doxorubicin widely used in transarterial HCC can induce immunogenic cell death (ICD), but resulting immunogenicity still weak. We aim seek a strategy for improving efficacy of ICD based on an immunoregulatory drug called icaritin. Icaritin induced mitophagy apoptosis provoke mouse Hepa1-6 human Huh7 cells. A combination icaritin doxorubicin with molar ratio 1:2 played...
<h3>Objectives</h3> Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral alcoholics, miR-223, one of the most abundant microRNAs (miRNAs) neutrophils, modulates neutrophil function ethanol-fed <h3>Designs</h3> Three hundred alcoholics with (n=140) or without (n=160) 45 healthy controls were enrolled. Mice fed an diet for 10 days followed by a single binge ethanol....
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Importance Homeostatic model assessment for insulin resistance (HOMA-IR) and triglyceride glucose (TyG) index–related parameters [TyG index, glucose–waist circumference (TyG-WC), glucose–waist-to-height ratio (TyG-WHtR), glucose–body mass index (TyG-BMI)] are gradually considered as convenient alternative indicators in various metabolic diseases, but the specific diagnostic capacity comparison of non-alcoholic fatty liver disease (NAFLD), metabolic-associated (MAFLD), fibrosis remain...
Background Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account the major component in TME, and dominance of M2 phenotype over M1 TIMs plays pivotal role sustaining character. We thus investigate effect bufalin on promoting polarization toward improve HCC immunotherapy. Methods The impact evoking antitumor immune response was evaluated immunocompetent mouse...
Abstract Background Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond well to immunotherapy, mainly due the stromal microenvironment and fibrosis-related immunosuppressive factors. The characteristic of sinusoidal endothelial cells (LSECs) contributing fibrosis orchestrating immune response is responsible for refractory targeted therapy or immunotherapy HCC. We aim seek a new strategy HCC treatment based on an old drug simvastatin which shows protecting effect LSEC....
Abstract Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, subsequent replication in separate cohort 907 2,127 controls. Our results show 14 risk loci including previously identified 6p21 ( HLA-DRA DPB1 ), 17q12 ORMDL3 3q13.33 CD80 2q32.3 STAT1 / STAT4 3q25.33 IL12A 4q24 NF-κB ) 22q13.1 RPL3 SYNGR1 ). We also variants IL21 ,...
It remains crucial to develop a laboratory model for studying hepatitis B virus (HBV) chronic infection. We hereby produced recombinant covalently closed circular DNA (rcccDNA) in view of the key role cccDNA HBV persistence. A loxP-chimeric intron was engineered into monomeric genome precursor plasmid (prcccDNA), which excised using Cre/loxP-mediated recombination 3.3-kb rcccDNA nuclei hepatocytes. The chimeric spliced from RNA transcripts without interrupting life cycle. In cultured...
Covalently closed circular DNA of hepatitis B virus (HBV) is critical for viral persistence in vivo. We recently reported a technique involving recombinant covalently (rcccDNA) HBV by site-specific recombination. Using hydrodynamic injection, rcccDNA induces temporarily prolonged antigenemia immunocompetent mice, similar to acute resolving infection. In this study, we simulated the pathophysiological impact chronic reproduce mouse models. showed that achieved long-lasting presence...
Xiaozhi formula (XZF) is a practical Chinese herbal for the treatment of non-alcoholic fatty liver disease (NAFLD), which possesses an authorized patent certificate issued by State Intellectual Property Office China (ZL202211392355.0). However, underlying mechanism XZF treats NAFLD remains unclear.
Background Androgen receptor (AR) signalling contributes to male predominance in hepatocellular carcinoma (HCC), which is more pronounced HBV-endemic areas. Cell cycle-related kinase (CCRK) essential for AR-induced hepatocarcinogenesis but its molecular function HBV-associated HCC remains obscure. Objective To determine the of CCRK HCC. Design Transcriptional regulation was assessed by chromatin immunoprecipitation, promoter mutation and luciferase reporter assays. Hepatocellular...
Background: Traditional Chinese Medicine (TCM) JingYinGuBiao formula (JYGB) was recommended by the Expert consensus on diagnosis and treatment of COVID-19 infection in Shanghai.We evaluated safety efficacy JYGB treating mild patients.Methods: A prospective, double-blind, randomized, controlled trial conducted (ClinicalTrial.govregistration number: ChiCTR2200058695).A total 885 patients were randomized into group (administration JYGB,n=508) or control TCM placebo, n=377) with 7-day...