A5052504970- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Virus Infections Studies
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- RNA Interference and Gene Delivery
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Parasites and Host Interactions
- HIV Research and Treatment
- Quantum Dots Synthesis And Properties
- RNA modifications and cancer
- interferon and immune responses
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
Tianjin Medical University
2019-2025
National University of Defense Technology
2024-2025
Shanghai Public Health Clinical Center
2020-2025
Baotou Medical College
2019-2024
Children's Hospital of Zhejiang University
2017-2024
Nanjing Drum Tower Hospital
2018-2024
Kunming Medical University
2024
Nanjing University of Chinese Medicine
2024
Nantong University
2024
Inner Mongolia University of Science and Technology
2019-2024
Pathogenic viral infections represent a major challenge to human health. Host immune responses respiratory viruses are closely associated with microbiome and metabolism via the gut-lung axis. It has been known that host defense against influenza A virus (IAV) involves activation of NLRP3 inflammasome, however, mechanisms behind protective function not fully known. Here we show an isolated bacterial strain, Bifidobacterium pseudolongum NjM1, enriched in gut microbiota Nlrp3-/- mice, protects...
Abstract Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) influenza viruses continue to pose a global health burden. Thus, we developed chimpanzee adenovirus-based combination vaccine, AdC68-HATRBD, with dual specificity against SARS-CoV-2 virus. When used as standalone intranasal immunization AdC68-HATRBD induced comprehensive potent immune responses consisting of immunoglobin (Ig) G, mucosal IgA, neutralizing antibodies,...
ABSTRACT In this study we compared a prime-boost regimen with two serologically distinct replication-defective adenovirus (Ad) vectors derived from chimpanzee serotypes C68 and C1 expressing Gag, Pol, gp140, Nef of human immunodeficiency virus type 1 in which Ad the serotype 5 (AdHu5) were given twice. Experiments conducted rhesus macaques that had or not been preexposed to antigens AdHu5. There was no significant difference T-cell responses tested peripheral blood different groups, although...
In order to better understand the broad applicability of adenovirus (Ad) as a vector for human vaccine studies, we compared four vectors from families C (Ad serotype 5 [HAdV-5; here referred AdHu5]), D (HAdV-26; AdHu26), and E (simian serotypes SAdV-23 SAdV-24; chimpanzee 6 7 [AdC6 AdC7, respectively]) Adenoviridae. Seroprevalence rates titers neutralizing antibodies two human-origin Ads were found be higher than those reported previously, especially in countries sub-Saharan Africa....
The neovascular form of age-related macular degeneration (nvAMD) is the leading cause blindness in elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role choroidal neovascularization (CNV), and anti-VEGF therapy recommended as first-line for nvAMD. However, many patients do not radically benefit from this therapy. Epidemiological data suggest that physical exercise beneficial human diseases, including Yet, its protective mechanism therapeutic potential remain...
Regulation of cell migration is an important feature tetraspanin CD151. Although it well established that CD151 physically associates with integrins, the mechanism by which regulates integrin-dependent basically unknown. Given fact localized in both plasma membrane and intracellular vesicles, we found its associated alpha3beta1, alpha5beta1, alpha6beta1 integrins undergo endocytosis accumulate same vesicular compartments. contains a YRSL sequence, YXXvarphi type endocytosis/sorting motif,...
The recent outbreak of Zika virus (ZIKV) has emerged as a global health concern. ZIKV can persist in human semen and be transmitted by sexual contact, well mosquitoes, seen for classical arboviruses. We along with others have previously demonstrated that infection leads to testis damage infertility mouse models. So far, no prophylactics or therapeutics are available; therefore, vaccine development is urgently demanded. Recombinant chimpanzee adenovirus been explored the preferred vector many...
We analysed the association between influenza A(H7N9) confirmed cases and exposure to poultry in Huzhou city, China. All (n=12) had a history of direct or live markets. detected A(H7N9)-positive samples from each site that was epidemiologically associated with cases. None cases’ close contacts tested positive. After closure markets, no new were identified, suggesting an epidemiological link virus infection.
Abstract Regulatory T (T reg ) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve lineage-specific features mostly unknown. Here, we show Lkb1 maintains cell identity stabilizing enforcing function. Upon receptor (TCR) stimulation protein is upregulated in not conventional cells. Mice with cell-specific deletion of develop fatal early-onset autoimmune disease, no most stabilizes...
Efficient recruitment and angiogenesis of endothelial progenitor cells (EPCs) are critical during a thrombus event. However, the details EPC regulation have not been fully determined. The aim this study was to determine role long noncoding (lnc)RNA Wilms tumor 1 associated protein pseudogene (WTAPP1) in migration EPCs. EPCs were isolated from human peripheral blood characterized by flow cytometry, after which lentivirus-mediated lncRNA WTAPP1 overexpression knockdown performed. Scratch...
Covalently closed circular DNA of hepatitis B virus (HBV) is critical for viral persistence in vivo. We recently reported a technique involving recombinant covalently (rcccDNA) HBV by site-specific recombination. Using hydrodynamic injection, rcccDNA induces temporarily prolonged antigenemia immunocompetent mice, similar to acute resolving infection. In this study, we simulated the pathophysiological impact chronic reproduce mouse models. showed that achieved long-lasting presence...
Abstract Deciphering the complicated excited-state process is critical for development of luminescent materials with controllable emissions in different applications. Here we report emergence a photo-induced structural distortion accompanied by an electron redistribution series gold nanoclusters. Such unexpected slow transformation results near-infrared dual emission extended photoluminescent lifetime. We demonstrate that this exhibits highly sensitive and ratiometric response to solvent...
Abstract Interfacial charge transfer is a fundamental and crucial process in photoelectric conversion. If not fast enough, carrier harvesting can compromise with competitive relaxation pathways, e.g., cooling, trapping, recombination. Some of these processes strongly affect the speed efficiency In this work, it elaborated that plasmon‐induced hot‐electron (HET) from tungsten suboxide to graphene sufficiently prevent cooling trapping processes. A near‐infrared detector empowered by HET...
Non-noble metal plasmonic materials, e.g. doped semiconductor nanocrystals, compared to their noble counterparts, have shown unique advantages, including broadly tunable plasmon frequency (from visible infrared) and rich surface chemistry. However, the fate harvesting of hot electrons from these non-noble plasmons been much less explored. Here we report driven electron generation transfer oxide nanocrystals adsorbed molecules by ultrafast transient absorption spectroscopy. We show...
Abstract Chimeric antigen receptor (CAR) T cells show suboptimal efficacy in acute myeloid leukemia (AML). We find that CAR exposed to impaired activation and cytolytic function, accompanied by downstream calcium, ZAP70, ERK, C-JUN signaling, compared those B-cell leukemia. These defects are caused part the high expression of CD155 AML. Overexpressing C-JUN, but not other components, maximally restores anti-tumor function. overexpression increases costimulatory molecules cytokines through...
Colloidal ZnO semiconductor nanocrystals have previously been shown to accumulate multiple delocalized conduction-band electrons under chemical, electrochemical, or photochemical reducing conditions, leading emergent semimetallic characteristics such as quantum plasmon resonances and raising prospects for application in multielectron redox transformations. Here, we demonstrate a dramatic enhancement the capacitance of colloidal through aliovalent Fe3+-doping. Very high areal volumetric...