A5047713923- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Bone Metabolism and Diseases
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Bone health and treatments
- Nerve injury and regeneration
- Cancer Immunotherapy and Biomarkers
- Bone health and osteoporosis research
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Inflammasome and immune disorders
- Electrospun Nanofibers in Biomedical Applications
- Venous Thromboembolism Diagnosis and Management
- RNA Research and Splicing
- Atherosclerosis and Cardiovascular Diseases
- Blood transfusion and management
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
Affiliated Hospital of Southwest Medical University
2016-2025
Southwest Medical University
2011-2025
British Heart Foundation
2021-2025
King's College London
2020-2025
Northwest A&F University
2024-2025
Tianjin Hospital
2012-2024
Nantong University
2010-2024
First Affiliated Hospital of Sichuan Medical University
2011-2024
Xuzhou Medical College
2014-2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Generally, mRNAs that prematurely terminate translation are abnormally low in abundance. In the case of mammalian cells, nonsense codons most often mediate a reduction abundance newly synthesized, nucleus-associated mRNA by mechanism is not well understood. With aim defining cis-acting sequences important to process, effects particular β-globin gene rearrangements on metabolism harboring one series have been assessed. Results indicate located 54 bp or more upstream 3′-most intron, intron 2,...
Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In case human triosephosphate isomerase (TPI gene), codons located less than 50 55 bp upstream intron 6, 3'-most intron, fail mediate mRNA decay. With aim understanding feature(s) TPI 6 confer function in positioning boundary between do not decay, effects deleting or duplicating introns been assessed. The results demonstrate functions position...
All eukaryotic cells analyzed have developed mechanisms to eliminate the production of mRNAs that prematurely terminate translation. The are thought exist protect from deleterious effects in-frame nonsense codons generated by routine inefficiencies and inaccuracies in RNA metabolism such as pre-mRNA splicing. Depending on particular mRNA how it is produced, can mediate a reduction abundance either ( i ) before its release an association with nuclei into cytoplasm, presumably but not...
Abstract Regulatory T (T reg ) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve lineage-specific features mostly unknown. Here, we show Lkb1 maintains cell identity stabilizing enforcing function. Upon receptor (TCR) stimulation protein is upregulated in not conventional cells. Mice with cell-specific deletion of develop fatal early-onset autoimmune disease, no most stabilizes...
Prompt and strong reconnection of severed peripheral nerves is crucial to nerve regeneration. The development biocompatible adhesives that are stronger than commonly used fibrin glue would be extremely beneficial this field. We designed an in situ forming adhesive hydrogel composed chitosan ε-polylysine (PL), which mimics the polysaccharides/protein structure natural epineurium matrices, thus, enhancing compatibility with nerves. Michael-type addition between maleimide thiol group was...
Human FOXP3
Abstract Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases deposits extracellular Aβ fibrils but also inhibits activation NRLP3 inflammasome. Here, we aimed to identify potent autophagy enhancers from Penthorum chinense Pursh (PCP) that alleviate pathology AD via inhibiting Methods At first, activity-guided isolation was performed PCP. Secondly,...
Hypertension is a major risk factor for cardiovascular diseases. However, vascular remodelling, hallmark of hypertension, has not been systematically characterized yet. We described systematic especially the artery type- and cell type-specific changes, in hypertension using spontaneously hypertensive rats (SHRs).
Ultrasonic flowmeters play an important role in industrial production, aerospace and other fields. In this paper, a high-precision ultrasonic flowmeter based on the cross-correlation method is designed, commercial finite element software COMSOL Multiphysics 5.6 used to simulate propagation process of waves during flow measurement, implementation algorithm simulated by Python language. The adopts improve measurement accuracy time flight combining FPGA embedded microprocessor operation...
Natural small molecule compounds play crucial roles in regulating fat deposition. Beta-sitosterol exhibits multiple biological activities such as cholesterol reduction and anticancer effects. However, its regulatory mechanism the differentiation of bovine preadipocytes remains unclear. We identified potential associations with processes regulation lipid metabolism through prediction targets. utilized techniques Oil Red O staining, Western blotting, RNA-seq, others to elucidate promoting...