A5008963233- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Aeolian processes and effects
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Geology and Paleoclimatology Research
- Cardiovascular Health and Disease Prevention
- Spinal Dysraphism and Malformations
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- Spinal Cord Injury Research
- Transplantation: Methods and Outcomes
- Pathogenesis and Treatment of Hiccups
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Geological formations and processes
Chengdu University of Traditional Chinese Medicine
2024
First Affiliated Hospital Zhejiang University
2021-2024
Zhejiang University
2023
King's College London
2017-2020
British Heart Foundation
2019
Linyi University
2015
Shandong Normal University
2015
Objective- Vascular adventitia encompasses progenitors and is getting recognized as the major site of inflammation in early stage atherosclerosis. However, cellular atlas heterogeneous adventitial cells, intercellular communication, response to hyperlipidemia, its contribution atherosclerosis have been elusive. Approach Results- Single-cell RNA sequencing was applied wt (wild type) ApoE (apolipoprotein E)-deficient aortic from 12-week-old C57BL/6J mice fed on normal laboratory diet with...
Transplantation-accelerated arteriosclerosis is one of the major challenges for long-term survival patients with solid organ transplantation. Although stem/progenitor cells have been implicated to participate in this process, origin and underlying mechanisms not fully defined.The objective our study was investigate role c-Kit lineage allograft-induced neointima formation explore process.Using an inducible tracing Kit-CreER;Rosa26-tdTomato mouse model, we observed that expressed multiple cell...
Hypertension is a major risk factor for cardiovascular diseases. However, vascular remodelling, hallmark of hypertension, has not been systematically characterized yet. We described systematic especially the artery type- and cell type-specific changes, in hypertension using spontaneously hypertensive rats (SHRs).
• A calcium alginate hydrogel combined with DPSC and FGF21 were synthesized. Ca2+@Alg-FGF21 + promotes the reconnection of spinal cord cross-section. cell migration differentiation. The protects neurons via inhibiting apoptosis promoting autophagy. effectively recovery motor function in HSCI mice. Spinal injury (SCI) often leads to persistent functional deficits due loss glia after injury. Hemisection (HSCI) is a special type SCI. most important difference between SCI occurrence dissection....
Adventitial progenitor cells, including SCA-1+ and mesenchymal stem are believed to be important in vascular remodeling. It has been shown that cells involved neointimal hyperplasia of vein grafts, but little is known concerning their involvement hyperlipidemia-induced atherosclerosis. We employed single-cell sequencing technology on primary adventitial mouse from wild-type atherosclerotic-prone (ApoE-deficient) mice found a group genes controlling cell migration matrix protein degradation...
Rationale: Transplant arteriosclerosis is the major limitation to long-term survival of solid organ transplantation. Although both immune and nonimmune cells have been suggested contribute this process, complex cellular heterogeneity within grafts, underlying mechanisms regulating disease progression remain largely uncharacterized. Objective: We aimed delineate allografts, explore possible process. Methods Results: Here, we reported transcriptional profiling 11 868 in a mouse model...
Vein graft failure remains a significant clinical problem.Similar to other vascular diseases, stenosis of vein grafts is caused by several cell lines; however, the sources these cells remain unclear.The objective this study was investigate cellular that reshape grafts.By analyzing transcriptomics data and constructing inducible lineage-tracing mouse models, we investigated components their fates.The sc-RNAseq suggested Sca-1+ were vital players in might serve as progenitors for multilineage...
The ambiguous results of multiple CD34+ cell-based therapeutic trials for patients with heart disease have halted the large-scale application stem/progenitor cell treatment. This study aimed to delineate biological functions heterogenous populations and investigate net effect intervention on cardiac remodeling. We confirmed, by combining single-cell RNA sequencing human mouse ischemic hearts an inducible Cd34 lineage-tracing model, that Cd34+ cells mainly contributed commitment mesenchymal...
The increasing incidence of arteriosclerosis has become a significant global health burden. Arteriosclerosis is characterized by the thickening and hardening arterial walls, which can lead to narrowing or complete blockage blood vessels. However, pathogenesis disease remains incompletely understood. Recent research shown that stem progenitor cells found in bone marrow local vessel walls play role development differentiating into various types vascular cells, including endothelial smooth...