A5022397831- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Electron and X-Ray Spectroscopy Techniques
- Spinal Cord Injury Research
- Fibroblast Growth Factor Research
- Advanced Electron Microscopy Techniques and Applications
- Quasicrystal Structures and Properties
- Integrated Circuits and Semiconductor Failure Analysis
- Tissue Engineering and Regenerative Medicine
- Mineralogy and Gemology Studies
- X-ray Diffraction in Crystallography
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Surface and Thin Film Phenomena
- Barrier Structure and Function Studies
- Neuroscience of respiration and sleep
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Quantum and electron transport phenomena
- Mesenchymal stem cell research
- Semiconductor materials and devices
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Extracellular vesicles in disease
Wenzhou Medical University
2016-2025
Zhejiang Lab
2023-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2025
The First People's Hospital of Wenling
2025
Wenzhou University
2018-2025
Institute of Macromolecular Chemistry
2025
University of Chinese Academy of Sciences
2025
Micron (United States)
2010-2024
Lishui University
2024
Zhejiang University
2024
Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures reduce all kinds of trauma and improve the combat effectiveness troops, it is imperative develop new strategies scaffolds promote bone regeneration.
Electrical stimulation (ES) has shown beneficial effects in repairing injured tissues. However, current ES techniques that use tissue-traversing leads and bulky external power suppliers have significant limitations translational medicine. Hence, exploring noninvasive vivo to provide controllable electrical cues tissue engineering is an imminent necessity. Herein, a conductive hydrogel with situ generation capability as biodegradable regeneration scaffold wireless platform for spinal cord...
Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results from an overproduction of fibroblasts excessive deposition collagen. Studies suggest a possible anti-scarring effect basic fibroblast growth factor (bFGF) during wound healing, but the precise mechanisms bFGF still unclear. In view this, we investigated therapeutic effects on HTS animal model as well human scar (HSF) model. We show that promoted healing reduced area flattened non-pathological in rat...
Abstract Therapeutics used to treat central nervous system (CNS) injury were designed repair neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 exerts potential neuroprotective effects after cerebral ischemia injury. However, little is known about the role of endogenous in recovery process spinal cord (SCI). In this study, we found mainly produced by neuron microglia/macrophages, its expression increased SCI. Exogenous treatment improved functional...
Heart attack is a global health problem that leads to significant morbidity, mortality, and care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally higher capacity than mammals. The extracellular matrix (ECM) may contribute this difference. Mammalian cardiac ECM not be optimally inductive for regeneration because of the fibrotic, instead regenerative, responses in injured adult mammalian hearts. Given high...
Summary Aim To investigate the mechanism of endoplasmic reticulum (ER) stress–induced apoptosis as well protective action basic fibroblast growth factor ( bFGF ) both in vivo and vitro . Methods Results ER was involved injuries spinal cord injury (SCI) model rat. administration improved recovery increased survival neurons lesions The effect is related to inhibition CHOP, GRP78 caspase‐12, which are response proteins. also expression growth‐associated protein 43 (GAP43), neural regeneration....
Abstract Apelin is highly expressed in the lungs, especially pulmonary vasculature, but functional role of apelin under pathological conditions still undefined. Hypoxic hypertension most common cause acute right heart failure, which may involve remodeling artery and regulation autophagy. In this study, we determined whether treatment with regulated proliferation migration rat arterial smooth muscle cells ( SMC s) hypoxia, investigated underlying mechanism relationship Our data showed that...
Endoplasmic reticulum (ER) stress-induced apoptosis plays a major role in various diseases, including spinal cord injury (SCI). Nerve growth factor (NGF) show neuroprotective effect and improve the recovery of SCI, but relations ER NGF therapeutic SCI still unclear. Young adult female Sprague-Dawley rats's vertebral column was exposed laminectomy done at T9 vertebrae moderate contusion injuries were performed using vascular clip. stock solution diluted with 0.9% NaCl administered...
Abstract Autophagy is involved in the development and/or progression of many diseases, including myocardial ischemia/reperfusion (I/R). In this study, we hypothesized a protective role basic fibroblast growth factor (bFGF) both vivo and vitro demonstrated that excessive autophagy ubiquitinated protein accumulation I/R model. Our results showed bFGF improved heart function recovery increased survival cardiomyocytes The effect related to inhibition LC3II levels. Additionally, enhances...
Low back pain, mainly caused by intervertebral disc degeneration (IVDD), is a common health problem; however, current surgical treatments are less than satisfactory. Thus, it essential to develop novel non-invasive methods for IVDD treatment. Here, we describe therapeutic strategy inhibit injecting hydrogels modified with the extracellular matrix of costal cartilage (ECM-Gels) that loaded endplate stem cells (CESCs). After CESCs overexpressing Sphk2 (Lenti-Sphk2-CESCs) and injected near...
Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of spinal cord, overly rigid hydrogels cannot be used treat SCI. Hence, we TPA Laponite develop hydrogel with shear-thinning ability. This exhibits good deformation, allowing it match physical properties cord; additionally, this scavenges ROS well, inhibit lipid peroxidation caused by ferroptosis. According in vivo studies, TPA@Laponite could synergistically ferroptosis improving vascular function...
Abstract The nerve guidance conduits incorporated with stem cells, which can differentiate into the Schwann cells (SCs) to facilitate myelination, shows great promise for repairing severe peripheral injury. innovation of advanced hydrogel materials encapsulating is highly demanded generating supportive scaffolds and adaptive microenvironment regeneration. Herein, this work demonstrates a novel strategy in regulating regenerative repair biodegradable conductive scaffold, offer multifunctional...
Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown have therapeutic potential in some heart disorders, including ischaemic In this study, we demonstrate that bFGF administration can inhibit the endoplasmic reticulum (ER) stress and mitochondrial dysfunction induced a mouse model of I/R vitro, exerts protective effect by inhibiting ER response...
// Zhouguang Wang 1 , Yan Huang Yi Cheng Tan 1,2 Fenzan Wu Jiamin Hongxue Shi Hongyu Zhang Xichong Yu Hongchang Gao Li Lin Jun Cai 2 Jinsan Xiaokun Lu and Jian Xiao Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory Biotechnology Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Department Pediatrics, Children's Hospital Institute, the University Louisville, Kentucky, USA Correspondence to: Xiao, email: Cai,...
Fibroblasts play a pivotal role in the process of cutaneous wound repair, whereas their migratory ability under diabetic conditions is markedly reduced.In this study, we investigated effect basic fibroblast growth factor (bFGF) on human dermal migration high-glucose environment.bFGF significantly increased by increasing percentage fibroblasts with high polarity index and reorganizing F-actin.A significant increase intracellular reactive oxygen species (ROS) was observed following bFGF...
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent...
Background:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate have become novel signaling targets for the development of cancer therapeutic drugs.Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical trials research; however, role ER stress effects curcumin new analogues remains unclear.Methods: Cell viability was determined using MTT assay.Apoptosis detected flow cytometry with...