A5072433757- Lymphoma Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer-related gene regulation
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- T-cell and Retrovirus Studies
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
Fudan University Shanghai Cancer Center
2025
Hubei University of Technology
2022-2025
Sun Yat-sen University
2006-2024
Sun Yat-sen University Cancer Center
2019-2024
Tianjin Institute of Pharmaceutical Research (China)
2019-2024
Xuzhou Medical College
2008-2023
Chongqing Medical University
2016-2023
Second Affiliated Hospital of Chongqing Medical University
2020-2023
Yangzhou University
2015-2023
Shanghai University of Traditional Chinese Medicine
2005-2023
Abstract Background The widespread application of colonoscopy screening and genetic testing in colorectal cancer (CRC) treatment has led to the identification a subset familial adenomatous polyposis (FAP) patients who lack family history disease but harbor germline gene mutations. Moreover, distinct genotypes may be associated with varied clinical presentations therapeutic options. This case report describes male patient de novo FAP harbored double heterozygosity (GDH) for APC BRCA2...
Forkhead box (FOX) F2 and FOXC2 belong to the FOX transcription factor superfamily. is recognized as an inducer of epithelial–mesenchymal transition (EMT), its overexpression promotes basal-like breast cancer (BLBC) metastasis. Our previous study demonstrated that FOXF2 functions EMT suppressor deficiency BLBC However, relationship between opposite EMT-related factors remains unknown. Here, we found directly targets negatively regulate in cells. Functionally, observed mediates...
// Zhouguang Wang 1 , Yan Huang Yi Cheng Tan 1,2 Fenzan Wu Jiamin Hongxue Shi Hongyu Zhang Xichong Yu Hongchang Gao Li Lin Jun Cai 2 Jinsan Xiaokun Lu and Jian Xiao Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory Biotechnology Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Department Pediatrics, Children's Hospital Institute, the University Louisville, Kentucky, USA Correspondence to: Xiao, email: Cai,...
Advanced natural killer/T cell lymphoma (NKTL) has demonstrated poor prognosis with currently available therapies. Here, we report the efficacy of anti-programmed death 1 (PD-1) antibody P-GEMOX (pegaspargase, gemcitabine, and oxaliplatin) regimen in advanced NKTL. Nine patients underwent six 21-day cycles anti-PD-1 (day 1), pegaspargase 2000 U/m2 gemcitabine g/m2 (days 8) oxaliplatin 130 mg/m2 followed by maintenance every 3 weeks. Programmed death-ligand (PD-L1) expression genetic...
Sexual dysfunction is a common long-term complication of cervical cancer and its treatment. However, due to traditional Chinese culture, there are few studies on interventions improve sexual function in China.To evaluate the effectiveness nurse-led positive psychology intervention function, depression subjective well-being amongst postoperative patients with early-stage cancer.A randomized controlled trial.Patients who had undergone radical hysterectomy for were followed up gynaecological...
Rationale : Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on function and how mediates cytoprotection following injury. Objective To examine IGFBP-3–mediated repair Methods Results We used 2 complementary injury models: laser occlusion retinal vessels in adult green fluorescent (GFP)...
The molecular regulation of the invasion osteosarcoma (OS) remains elusive. Here, we reported significant lower level miR-143 and levels phosphorylated EGFR MMP9 in resected OS from patients, compared to adjacent normal tissue. Moreover, strong correlation was detected among these three factors. We thus hypothesized existence a causal link, which prompted us use two human cell lines study interaction miR-143, MMP9, activation signaling. found that EGF-induced phosphorylation both activated...
Metabolic syndrome (MetS) is associated with nephropathy. Along common risk factors such as hypertension and hyperglycemia, adipocytokines released from perirenal adipose tissue (PRAT) are implicated in the pathogenesis of MetS The study was designed to elucidate adverse effects PRAT-derived leptin on nephropathy determine whether angiotensin II type 1 receptor antagonist telmisartan exerts a renoprotective effect by decreasing level high-fat diet-induced rat. In rats, expression increased...
Collagen XI, a member of the collagen family, is present in extracellular matrix (ECM), and high XI/αI (COL11A1) expression tumor tissue reportedly correlated with clinicopathological parameters pancreatic ductal adenocarcinoma (PDAC).However, function COL11A1 development cancer cells remains unclear.In current study, we assessed mRNA its receptors created testing-model both COL11A1-overexpressing microenvironment and/or altered-COL11A1 cell lines.Next, investigated mechanism by which...
Abstract Extranodal natural killer/T‐cell lymphoma, nasal‐type (ENKTL) is a distinct subtype of non‐Hodgkin lymphoma and most the patients presented localized disease. Combined modality therapy (CMT), namely chemotherapy combined with radiotherapy, has been recommended for early‐stage ENKTL. However, optimal CMT not fully clarified. This study reports efficacy toxicity sequential P‐GEMOX (pegaspargase, gemcitabine oxaliplatin) radiotherapy in large Chinese cohort comprising 202 diagnosed...
Although anti-vascular endothelial growth factor (VEGF) treatments reduce pathological neovascularization in the eye and tumors, regression is often not sustainable or incomplete. We investigated whether vascular cells circumvent anti-VEGF therapies by activating unfolded protein response (UPR) to override classic extracellular VEGF pathway. Exposure of VEGF, high glucose, H2O2 up-regulated X-box binding protein-1/inositol-requiring protein-1 (IRE1) α transcription 6 (ATF6) arms UPR compared...
Fractalkine (FKN, CX3CL1) is highly expressed in a majority of malignant solid tumours. the only known ligand for CX3CR1. In this study, we performed an analysis to determine effects fractalkine/CX3CR1 on modulating apoptosis and explored related mechanisms. The expression was detected by immunohistochemistry western blotting. levels AKT/p-AKT, BCL-xl, BCL-2 were Then, exogenous endogenous fractalkine regulation tumour proliferation investigated. mechanism cancer cells through activation...
Tenascin-C (TNC), a large extracellular matrix glycoprotein, has been reported to be associated with metastasis and poor prognosis in pancreatic cancer. However, the effects mechanisms of TNC cancer largely remain unclear. We performed Transwell assays investigate on Capan-2, AsPC-1 PANC-1 cells. In addition, western blot RT-qPCR were used examine potential metastasis-associated targets, such as JNK/c-Jun, Paxillin/FAK, E-cadherin, N-cadherin, Vimentin, MMP9/2. Lastly, we utilized variety...
Osteosarcoma is the most prevalent malignant bone tumor in children and adolescents. Lung metastases are associated with poor prognosis.The aim here was to explore prevalence of risk prognostic factors for lung high-grade osteosarcoma patients.Retrospective cohort study based on Surveillance, Epidemiology End Results (SEER) database United States.Data 1,408 patients registered SEER between 2010 2015 were extracted. From these, all initial metastasis selected analysis metastases. Overall...
Alteration of podocyte behavior is critically involved in the development and progression many forms human glomerular diseases. The molecular mechanisms that control behavior, however, are not well understood. Here, we investigated role Kindlin-2, a component cell-matrix adhesions, vivo . Ablation Kindlin-2 podocytes resulted alteration actin cytoskeletal organization, reduction levels slit diaphragm proteins, effacement foot processes, ultimately massive proteinuria death due to kidney...
Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of leading causes breast cancer-related death. To verify performance clinicomics-guided distant risk prediction for via artificial intelligence and to investigate accuracy created models metachronous metastasis, bone visceral metastasis.We retrospectively enrolled 6703 patients from 2011 2016 in our hospital. The figures magnetic resonance imaging scanning ultrasound were collected, features...