A5100460910- Sirtuins and Resveratrol in Medicine
- Toxin Mechanisms and Immunotoxins
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Nuts composition and effects
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Health Systems, Economic Evaluations, Quality of Life
- Melamine detection and toxicity
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Biomedical Research and Pathophysiology
- Polyoxometalates: Synthesis and Applications
- Effects of Radiation Exposure
- Genomics, phytochemicals, and oxidative stress
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Boron and Carbon Nanomaterials Research
- Cancer therapeutics and mechanisms
- Aluminum Alloys Composites Properties
- Calcium signaling and nucleotide metabolism
Nankai University
2011-2025
Tianjin University of Traditional Chinese Medicine
2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Tongji Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
National Vaccine and Serum Institute
2023
State Key Laboratory of Oncogene and Related Genes
2023
Shanghai Jiao Tong University
2023
Southwest Minzu University
2023
Sirtuins play an important role in cancer development. Sirt7, as a member of this family, is frequently overexpressed certain carcinomas, but the oncogenic mechanism seldom reported. In study, Sirt7 was characterized for its colorectal aggressiveness and underlying molecular mechanisms.Quantitative PCR, Western blotting, immunohistochemistry were performed to study expression cohort tissues non-tumor cells. A series vitro vivo assays elucidate function mechanisms. Association between...
Two in one: pseudorotaxanes can be combined to form a twin-axial hetero[7]rotaxane (see picture) by using the copper-catalyzed alkyne–azide "click" reaction. The synthetic route, which and single-axial rotaxanes are formed, combines self-assembly formation of covalent bonds ensure correct positioning two types rings final product. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family protein deacylase that catalyzes removal post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light SIRT5's roles in regulating mitochondrion function, we show here SIRT5 deficiency leads to suppression mitochondrial NADH oxidation inhibition ATP synthase activity. As result, decreases production, increases AMP/ATP ratio, subsequently activates AMP-activated kinase...
Radiation enteritis (RE) is the most common radiotherapy complication, and effective RE treatments are lacking. Resveratrol exerts beneficial effects on radiation injury. However, effect of resveratrol in radiation-induced intestinal injury underlying mechanism remain unclear. Here, a C57BL/6 mouse model was established an epithelial cell line used to evaluate protective against mechanisms. improved oxidative stress apoptosis via upregulating antioxidant enzymes downregulating p53...
The SARS-CoV-2 Omicron variant evades most currently approved neutralizing antibodies (nAbs) and caused drastic decrease of plasma activity elicited by vaccination or prior infection, urging the need for development pan-variant antivirals. Breakthrough infection induces a hybrid immunological response with potentially broad, potent durable protection against variants, therefore, convalescent from breakthrough may provide broadened repertoire identifying elite nAbs. We performed single-cell...
Abstract Resveratrol (3,5,4'‐tihydroxy‐trans‐stilbene), a polyphenolic phytoalexin found in the skin and seeds of grapes, has been reported to possess wide range biological pharmacological activities including antioxidant, anti‐inflammatory, antimutagenic effects. The present study intended explore neuroprotective effects resveratrol against Aβ 25–35 ‐induced neurotoxicity cultured mouse cortical neurons possible mechanisms involved. For this purpose, were exposed 30 μM absence or presence...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary cause pathogenesis Alzheimer's disease (AD). And elimination Aβ25-35 is considered important target for treatment AD. Triptolide (TP), isolated from Tripterygium wilfordii Hook.f. (TWHF), has been shown to possess a broad spectrum biological profiles, including neurotrophic and neuroprotective effects. In our study investigating effect potential mechanism triptolide on cytotoxicity...
Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role mechanism of action norcantharidin in increasing CRC sensitivity radiotherapy. We treated cell lines LoVo DLD-1 with NCTD (10 or 50 μmol/L), ionizing radiation (IR, 6 Gy), combination two found that significantly inhibited proliferation cells enhanced their induced by decreasing mitochondrial membrane potential, permeability, promoting cytochrome C...
Zwei in einem: Pseudorotaxane können mithilfe der kupferkatalysierten Alkin-Azid-"Klick-Reaktion" zu einem Doppelachsen-Hetero[7]rotaxan (siehe Bild) kombiniert werden. Die Syntheseroute, doppelachsige und einachsige Rotaxane gebildet werden, Selbstorganisation die Knüpfung kovalenter Bindungen, um korrekte Positionierung beiden Ringarten im Endprodukt sicherzustellen.
Studies exploring the association of cognitive frailty and mortality have been mainly based on community settings or nursing home settings. The aim our study was to explore between 30-day among older Chinese inpatients.A national cohort performed in different hospitals China. A baseline survey conducted from October 2018 February 2019. Trained investigators collected mortality. Cognitive impairment were defined by Mini-Cog FRAIL scale, respectively. Multivariate regression used status with...
SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent histone/protein deacetylase, has been extensively studied recently for its critical role in the regulation of physiology, calorie restriction and aging. Studies on laboratory mice showed that expression SIRT1 can be induced by starvation p53-dependent manner requires p53-binding sites present Sirt1 promoter. However, it remains to determined whether these findings based rodents apply human beings. In this paper, we characterized...
Resveratrol, an activator for longevity regulatory genes-sirtuin family (SIRTs) and Sirtuin 2 (SIRT2) is important factor of SIRTs which demonstrated biological function in cancers, but the underlying mechanism unrevealed.We investigated mRNA protein levels SIRT2 a variety cancers potential role clinical prognosis, as well analysed association between gene immune infiltration various cancers. And analysis two types lung cancer was conducted to construct systematic prognostic landscape....
Radiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance crucial cause poor therapeutic outcomes in cancer. However, underlying mechanism radioresistance still poorly defined. Herein we established a radioresistant cell line and performed transcriptomics analyses to search genes that contribute investigate its association prognosis CRC patients.The was developed from parental HCT116 by stepwise increased dose irradiation....
Sirtuin 1 (SIRT1) overexpression significantly inhibits lipid deposition during yak intramuscular preadipocyte (YIMA) differentiation; however, the regulatory mechanism remains unknown. We elucidated role of SIRT1 in YIMA differentiation using lentivirus-mediated downregulation technology and conducted mRNA-seq ChIP-seq assays H3K9ac antibodies after order to reveal targets adipogenesis. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses were performed identify functional...