A5101931376- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Bone Tumor Diagnosis and Treatments
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Endometrial and Cervical Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Management of metastatic bone disease
- Cardiac tumors and thrombi
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Medical Imaging and Pathology Studies
- TGF-β signaling in diseases
- PI3K/AKT/mTOR signaling in cancer
- Musculoskeletal synovial abnormalities and treatments
- Retinoids in leukemia and cellular processes
- Medicinal Plant Pharmacodynamics Research
Tianjin Medical University Cancer Institute and Hospital
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking Union Medical College Hospital
2023
National Clinical Research
2019
Tianjin Medical University
2012-2019
Malignant bone tumors are a group of rare malignant and our study aimed to update the recent epidemiologic estimates based on Surveillance, Epidemiology End Results database. Patients diagnosed with from 2000 2019 were included their characteristics retrospectively described. The limited-duration prevalence, annual age-adjusted incidence mortality calculated, percentage changes analyzed quantify rate change. Finally, observed survival relative illustrated. Subgroup analysis across tumor...
The purpose of the present study was to characterize prevalence, associated factors, and construct a nomogram for predicting bone metastasis (BM) with different histological types lung cancer.This descriptive that basing on invasive cancer patients diagnosed between 2010 2014 in Surveillance, Epidemiology, End Results program. A total 125,652 adult were retrieved. Logistic regression analysis conducted investigate homogeneous heterogeneous factors BM occurrence. Nomogram constructed predict...
Hepatocellular carcinoma (HCC) is one of the most prevalent causes cancer-related morbidity and mortality worldwide. Late-stage detection complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded nucleic acid structures associated with genome instability, play a key role in malignant characteristics various tumors. However, detailed mechanism R-loops HCC remain elusive require further exploration. This study...
Osteosarcoma is a highly aggressive bone disease with tendency to metastasize the lung. The 5-year survival of patients metastatic osteosarcoma only 20 %. Many studies have demonstrated SDF-1/CXCR4 and MMP9 play important roles in metastasis malignant tumors, including osteosarcoma. aim this study was investigate association CXCR4 expression clinicopathological features pulmonary Using tumor tissue microarrays, we analyzed among 34 primary osteosarcomas 62 without metastasis. A median time...
Osteosarcoma is the most prevalent malignant bone tumor in children and adolescents. Lung metastases are associated with poor prognosis.The aim here was to explore prevalence of risk prognostic factors for lung high-grade osteosarcoma patients.Retrospective cohort study based on Surveillance, Epidemiology End Results (SEER) database United States.Data 1,408 patients registered SEER between 2010 2015 were extracted. From these, all initial metastasis selected analysis metastases. Overall...
Using the Surveillance, Epidemiology, and End Results database (SEER) to assess incidence risk factors of morbidity prognosis for bone metastases in initial metastatic prostate cancer.The records 249,331 cancer patients SEER database, diagnosed between 2010 2014, were obtained investigate developing metastasis, 9925 them who registered before 2013 retrieved (with at least 1 year follow up) explore prognostic metastasis. Multivariate logistic Cox regression used identify metastases,...
BACKGROUND:The aims of this study were to investigate the incidence and risk factors for development bone metastases prognosis in women with cancer uterine cervix using database analysis. MATERIAL AND METHODS:The National Cancer Institute (NCI) Surveillance, Epidemiology, End Results (SEER) was analyzed survival rates diagnosed cervical United States between 2010–2015. Multivariate logistic regression analysis identified metastases. Kaplan-Meier estimated overall survival. Proportional...
The purpose of this study was to assess the incidence and risk factors prognostic for bone metastasis (BM) in initial metastatic renal cell carcinoma (RCC) based on a large population analysis.Data were obtained total 45,824 RCC patients recorded database Surveillance, Epidemiology, End Results program National Cancer Institute between 2010 2014. Multivariate logistic Cox regression analyses used identify associated with BM patients. Kaplan-Meier analysis estimate overall survival patients,...
Purpose: Based on a large-population analysis, we aimed to estimate the incidence and survival of bone metastases (BM) in initial bladder cancer (BC) patients identify risk prognostic factors BC with BM.Patients methods: Using National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) database, diagnosed between 2010 2014 were retrieved.Multivariate logistic Cox regression analyses employed for BM patients.A Kaplan-Meier analysis log-rank test was used overall difference...
Background: Ovarian cancer (OC) is one of the most common malignancies in women. Advanced bone metastases (BM) commonly result poor prognosis. We aim to evaluate prevalence and associated factors for de novo BM development prognosis OC. Materials methods: The present study was a cohort that used United States based National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) database. SEER documented OC patients, diagnosed between 2010 2015, were included study. Univariable...
// Lin Li 1 , Shoulei Liang 2 Amanda R. Wasylishen 3 Yanqin Zhang Xueli Yang Bingzheng Zhou Luling Shan Xiuxin Han Tianyang Mu Guowen Wang Shunbin Xiong 1, Institute of Cancer Stem Cell, Dalian Medical University Center, Dalian, China Department Bone and Soft Tissue Tumors, Tianjin Hospital, National Clinical Research Center for Cancer, Key Laboratory Prevention Therapy, Tianjin, Genetics, The Texas MD Anderson Houston, Texas, United States America Correspondence to: Mu, e-mail:...
BACKGROUND The objective of the present research was to explore prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered Surveillance, Epidemiology, End Results (SEER) database, we enrolled 1263 BM at initial diagnosis from 2010 2014. Kaplan-Meier curves log-rank tests used estimate overall survival for different subgroups. Univariate multivariate...
Oral hypoglycemic agent metformin is commonly used for treating type II diabetes; however, initial reports demonstrated that it could be suppressing tumor growth in vitro and vivo. Moreover, novel potential anticancer drug histone deacetylase (HDAC) inhibitor trichostatin A (TSA) have been extensively studied inducing various malignancies inhibition, cell cycle arrest, apoptosis. The object of the present study was to investigate anti-proliferation apoptosis induction effects TSA...
Background Osteosarcoma is the most frequent type of malignant bone tumor in children and adolescents associated with a high propensity for lung metastasis. Recent experiments have indicated that PLA2G16 contributes to osteosarcoma progression metastasis both mouse human cell lines. The aim this study was compare expression non-metastatic metastatic osteosarcomas determine whether can serve as biomarker prognosis Methods Quantitative real-time PCR used examine mRNA primary patients (18...
This retrospective case-series study evaluated efficacy and safety of Endostar combined with chemotherapy in the treatment advanced bone soft tissue sarcomas stage IV.Forty-seven patients diagnosed IV treated Tianjin Medical University Cancer Institute & Hospital were reviewed. Of these patients, 23 plus (designated as group), 24 received only control group). Progression-free survival (PFS), overall (OS), objective response rate (ORR) clinical benefit (CBR) analyzed to find difference...
Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells named them MG-63/Dox HOS/Dox, respectively. The Dox had greater invasion ability than that of parental cells. expression ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased Silencing ZEB1 can attenuate metastasis increase sensitivity HOS/Dox upregulation interlukin-6 (IL-6)....
Background The purpose of this study was to develop a new prognostic model for osteosarcoma based on cuproptosis-mitochondrion genes. Materials and methods data were obtained from TARGET database. By using Cox regression LASSO analysis, novel risk score constructed Kaplan-Meier, ROC curve independent analyses performed validate the in GSE21257 dataset. Then, predictive nomogram further validated by calibration plot, C-index curve. Based score, all patients divided into high-risk low-risk...
Abstract Enhancer of zeste homologue 2 (EZH2) is a clarified promoter in list tumours, including osteosarcoma (OS). Our research was projected to define the mechanism involved EZH2‐mediated OS progression through protein kinase B (AKT)/glycogen synthase 3β (GSK3β) pathway. EZH2 expression tested 66 tissues and five cell lines (143B, SJSA‐1, HOS, MG63, U2OS). In HOS U2OS cells, cellular malignant characteristics, markers AKT/GSK3β signalling pathway were measured when silenced or...