Abstract Purpose The study aimed to investigate the prevalence of dry eye disease (DED) and relevant risk factors among Chinese high school students during COVID-19 outbreak. Methods A cross-sectional was conducted from November December 2020, 4825 nine schools in Shanghai were recruited. All completed ocular surface index (OSDI) perceived stress scale (PSS) questionnaires answered other questions designed ascertain information on related DED. DED diagnosed when OSDI scores greater than or...

BACKGROUND The objective of the present research was to explore prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered Surveillance, Epidemiology, End Results (SEER) database, we enrolled 1263 BM at initial diagnosis from 2010 2014. Kaplan-Meier curves log-rank tests used estimate overall survival for different subgroups. Univariate multivariate...

The aim of this study was to examine the survival rate patients with different bone sarcomas and investigate homogenous heterogenous prognostic factors for types sarcomas.This is a retrospective analysis records from Surveillance, Epidemiology, End Result (SEER) database. Clear information on distant metastasis cancer provided in SEER database diagnosed between January 2010 December 2016. Data four malignant were extracted, including osteosarcoma, chondrosarcoma, Ewing sarcoma, chordoma....

Abstract Objective Limited by sample size, angiosarcoma was rarely studied. We aimed to investigate the characteristics and prognosis of in National Cancer Institute’s Surveillance, Epidemiology End Results database. Methods Patients who were diagnosed with primary from 1973 2014 extracted Kaplan–Meier analysis used estimate overall survival, difference between groups tested log-rank test. Multivariate Cox regression analyses employed identify prognostic factors for angiosarcoma. A total...

Protein expression in colon and rectal cancer (CRC) paired normal tissues was examined by two-dimensional gel electrophoresis (2-DE) to identify differentially expressed proteins.Five fresh colorectal adjacent were obtained protein spots determined using PDQuest software, with identification on the basis of MALDI- TOF mass spectra.Compared mucosa, abnormal 65 varying more than 1.5 times found 2-DE gels from samples (P<0.05); forty-two proteins up-regulated 23 down-regulated; twelve...

Abstract Background Pexidartinib (Turalio) is the only systemic therapy approved by FDA for treatment of adult patients with symptomatic tenosynovial giant-cell tumor (TGCT) associated severe morbidity or functional limitations, and not amenable to improvement surgery. This study assessed patient-reported experiences symptom among receiving pexidartinib. Methods A cross-sectional, web-based survey collected data on demographics, disease history, pexidartinib dosing, symptoms before after...

•Patients with HER2-mutant advanced/metastatic NSCLC used a wide range of therapies. •Duration treatment across lines therapy was modest. •HER2-directed infrequently in early before 2021. Background Real-world data for non-small cell lung cancer (NSCLC) mutations human epidermal growth factor 2 (HER2) are scarce. We aimed to assess patterns and outcomes among patients NSCLC. Patients methods This retrospective nationwide electronic health record study evaluated patient characteristics,...

Objective: Race disparities exist in bone metastasis (BM) development and survival lung cancer (LC) patients. The Surveillance, Epidemiology, End Results (SEER) database was used to investigate different patterns of BM races.Design: LC patients with were identified from the 2010 2014. Risk factors investigated by univariable multivariable logistic regression. Potential for prognosis evaluated Cox regression.Results: Asian Pacific Islander (API) presented highest prevalence (24.6%), followed...

Objectives: The present study aimed to evaluate the early mortality rate and associated factors for death in bone soft tissue tumors, construct predictive nomogram. Methods: Patients diagnosed between 2010 2015 Surveillance, Epidemiology, End Results (SEER) dataset were enrolled. (survival time ≤ 3 months) was calculated risk evaluated by logistic regression models. significant used nomograms. Results: A total of 2,003 (8.5%) patients died within months after cancer diagnosis, among whom...

Background The occurrence of distant metastases (DM) limits the overall survival (OS) patients with chondrosarcoma (CS). Early diagnosis and treatment CS remains a great challenge in clinical practice. aim this study was to investigate metastatic factors develop risk stratification model for clinicians’ decision-making. Methods Six machine learning (ML) algorithms, including logistic regression (LR), plain Bayesian classifier (NBC), decision tree (DT), random forest (RF), gradient boosting...

Liposarcoma arising in the mediastinum is extremely rare. Herein we present a case of 47-year-old man with huge posterior mediastinal tumor that extended to bilateral thorax. The patient underwent complete resection and experienced an uneventful recovery. Postoperative pathology finally revealed liposarcoma. follow-up for 25 months, during which time no recurrence was found.

Objective: To assess the economic burden of tenosynovial giant cell tumor (TGCT) among US employed workforce. Methods: Patients with TGCT medical claims ( N = 1395) and matched controls (1:10) without 13,950) were identified from OptumHealth Care Solutions, Inc. database (January 1, 1999 to March 31, 2017). Adjusted regression models used compare healthcare resource utilization, time lost work, associated costs between cohorts. Results: In patients TGCT, rates inpatient admissions, emergency...

Objective: To understand the influence of meteorological factors on morbidity influenza in northern cities China and explore differences 15 cities. Methods: The monthly reported data from 2008 to 2020 were collected provincial capital cities, including Xi 'an, Lanzhou, Xining, Yinchuan Urumqi (5 northwestern cities), Beijing, Tianjin, Shijiazhuang, Taiyuan, Hohhot, Ji'nan, Zhengzhou (7 Shenyang, Changchun Harbin (3 northeastern cities). panel regression model was applied conduct quantitative...

Abstract Purpose: To investigate the possible correlation factors of choroidal thickness in ABCA4-related retinopathy. Methods: A total 66 patients were included cohort. It is a retrospective, cross-sectional laboratory investigation. The tested using whole exon sequencing (WES) and ophthalmic exams, including slip lamp best corrected visual acuity (BCVA), spectral-domain optical coherence tomography (SD-OCT), fundus photo (FP), autofluorescence (FAF). Results: Besides demographic...

The aim of this is study to assess the efficacy and safety conversion capecitabine plus oxaliplatin (XELOX) in Chinese patients with potentially resectable colorectal liver metastases (CLMs).Thirty (median age 57.5 years) CLMs were treated XELOX a single-arm, open-label, nonrandomized, multicenter clinical trial.The objective response rate 30 was 40% (95% confidence interval: 22.7%-59.4%), 43.3%. Patients who underwent resection (n = 11) had longer median progression-free survival overall...

e18737 Background: Tenosynovial giant cell tumor (TGCT) is a rare and locally aggressive that arises from synovium in joints, bursae, tendon sheaths. The objective was to examine treatment patterns of TGCT real-world setting. Methods: A retrospective claims analysis performed using the IQVIA Real-Word Data Adjudicated Claims - US Database. Adults who were diagnosed with (ICD-9: 727.02, 719.2x; ICD-10: D48.1, D21.x, M12.2) between 2011 2015 did not have any diagnosis 2 years pre-index...

Aim: The objectives were to investigate the differences in per patient month (PPPM) healthcare resource utilization (HCRU) and costs among commercially insured Medicare Advantage patients with human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer (mBC) who experience disease progression 12 months compared those don't impact of timing on cumulative costs. Patients &amp; methods: This claims-based study included diagnosed mBC between 1 January 2013 30 April 2020...

ABSTRACT Objectives Targeted therapies have been shown to improve outcomes in metastatic non‐small cell lung cancer (mNSCLC) with driver mutations. We evaluated the real‐world prevalence of human epidermal growth factor receptor 2 (HER2; ERBB2 ) tumor gene mutations among patients mNSCLC and described historical treatments HER2 ‐mutant mNSCLC, during a period when there was no approved targeted therapy for mNSCLC. Materials Methods This retrospective observational study used US nationwide...

Background: Tenosynovial giant cell tumor (TGCT) may be misdiagnosed as osteoarthritis (OA), or the chronic course of TGCT lead to development secondary OA. However, little is known about effect comorbid OA on long-term surgical patterns and costs among patients. Methods: This cohort study used claims data from Merative MarketScan Research Databases. The included adults diagnosed with January 1, 2014, June 30, 2019, who have at least 3 years continuous enrollment before after first diagnosis...

Trastuzumab in combination with chemotherapy is the standard first-line (1L) treatment for HER2+ metastatic gastric cancer (mGC) USA. This study characterizes real-world patterns, healthcare resource use (HRU), and costs patients mGC post-1L trastuzumab before approval of fam-trastuzumab deruxtecan-nxki. retrospective used IQVIA PharMetrics® Plus Database (October 2014-September 2019) to identify adults who discontinued trastuzumab-based regimens 1L. Patient characteristics, second-line (2L)...

e22527 Background: Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive and debilitating that generally affects young working-age adults. This study assessed work productivity loss in TGCT patients. Methods: Incident patients aged 18-64 years with diagnosis of TGCT, who had earning disability data, were identified the OptumHealth database (Q1 1999 – Q1 2017). Patients classified into surgical non-surgical groups depending on presence joint surgery claim postindex period....