A5082155253- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Dental Radiography and Imaging
- Temporomandibular Joint Disorders
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- dental development and anomalies
- Advanced Breast Cancer Therapies
- Graphene and Nanomaterials Applications
- Statistical Methods in Clinical Trials
- PARP inhibition in cancer therapy
- Dental materials and restorations
- Tuberous Sclerosis Complex Research
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Cleft Lip and Palate Research
- Dental Research and COVID-19
- Acute Lymphoblastic Leukemia research
Chongqing Medical University
2016-2025
Stomatological Hospital of Chongqing Medical University
2014-2025
Analysis Group (United States)
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2024
Southwest Medical University
2023
Stomatology Hospital
2022
Tianjin University of Commerce
2021
Ibero American University
2019
Hunan University
2017-2018
Eisai (United States)
2016
Scar formation is an intractable medical problem that appears after skin wounds have healed. Recent research has shown exosomes secreted by human adipose mesenchymal stem cells (ASC-Exos) can benefit wound healing. To further explore the therapeutic potential of ASC-Exos, we investigated their effects on mitigating scar formation, and underlying mechanisms these effects. We found intravenous injection ASC-Exos decreased size scars increased ratio collagen III to I in murine incisional...
The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases (such as matrix metalloproteinases, MMPs), etc. In view the fact that exosomes represent a promising nanomaterial, herein, we reported excellent capacity stem cells from apical papilla-derived (SCAP-Exo) to facilitate angiogenesis osteogenesis whether normal or diabetic conditions vitro. Then, bioresponsive polyethylene...
Nanohydroxyapatite (HA) synthesized by biomimetic strategy is a promising nanomaterial as bone substitute due to its physicochemical features similar those of natural nanocrystal in tissue. Inspired mussel adhesive chemistry, novel nano-HA was our work employing polydopamine (pDA) template under weak alkaline condition. Subsequently, the as-prepared pDA-templated HA (tHA) introduced into polycaprolactone (PCL) matrix via coelectrospinning, and bioactive tHA/PCL composite nanofiber scaffold...
Mucormycosis is a rare but devastating fungal infection primarily affecting immunocompromised patients such as those with hematological malignancy, bone marrow and solid organ transplantation, diabetes, and, even more rarely, immunocompetent patients. The objective of this study was to assess the prevalence burden, both clinical economic, mucormycosis among hospitalized in U.S.This retrospective using Premier PerspectiveTM Comparative Database, than 560 participating hospitals covering 104...
Bone healing is a dynamic process regulated by biochemical signals such as chemokines and growth factors, biophysical topographical mechanical features of extracellular matrix or stimuli. Hereby, mechanically tough bioactive hydrogel based on autologous injectable platelet-rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) developed. This composite demonstrates double network (DN) mechanism, wherein covalent serves to maintain material integrity, self-assembled colloidal GNPs...
Abstract Major depressive disorder (MDD) is a serious mental illness. Increasing evidence from both animal and human studies suggested that the gut microbiota might be involved in onset of depression via gut–brain axis. However, mechanism remains unclear. To explore protein changes axis modulated by microbiota, germ-free mice were transplanted with MDD patients to induce depression-like behaviors. Behavioral tests performed following fecal transplantation. A quantitative proteomics approach...
Infected bone defects (IBDs) exhibit impaired healing due to excessive inflammation triggered by pathogen-associated molecular patterns (PAMPs) from bacteria. As a vital factor in orchestrating immune responses, mitochondrial homeostasis maintenance is central blockade. This research developed chameleon-like nanoplatform covering hydroxyapatite nanoparticles with cerium ion coordinated tannic acid supramolecular network (HA@Ce-TA), which adaptively functions regulate based on intra- and...
Periodontal tissue destruction in periodontitis is a consequence of the host inflammatory response to periodontal pathogens, which could be aggravated presence type 2 diabetes mellitus (T2DM). Accumulating evidence highlights intricate involvement macrophage-mediated inflammation pathogenesis under both normal and T2DM conditions. However, underlying mechanism remains elusive. Alpha-2-glycoprotein 1 (AZGP1), glycoprotein featuring an MHC-I domain, has been implicated metabolic disorders. In...
Human periodontal ligament cells (hPDLCs) possess stem cell properties, which play a key role in regeneration. Physical stimulation at appropriate intensities such as low-intensity pulsed ultrasound (LIPUS) enhances proliferation and osteogenic differentiation of mesechymal cells. However, the impacts LIPUS on hPDLCs vitro its molecular mechanism are unknown. This study was undertaken to investigate effects hPDLCs. HPDLCs were isolated from premolars adolescents for orthodontic reasons,...
High variability in patients' changes 6 minute walk distance (6MWD) over time has complicated clinical trials of treatment efficacy Duchenne muscular dystrophy (DMD). We assessed whether boys with DMD could be grouped into classes that shared similar ambulatory function trajectories as measured by 6MWD. Ambulatory aged 5 years or older genetically confirmed who were enrolled a natural history study at 11 care centers throughout Italy included. For each boy, standardized assessments 6MWD...
The design and development of functional biomimetic systems for programmed stem cell response is a field topical interest. To mimic bone extracellular matrix, we present an innovative strategy constructing drug-loaded composite nanofibrous scaffolds in this study, which could integrate multiple cues from calcium phosphate mineral, bioactive molecule, highly ordered fiber topography the control fate. Briefly, inspired by mussel adhesion mechanism, polydopamine (pDA)-templated...
Since generating toxic reactive oxygen species is largely dependent on oxygen, bacteria-infected wounds' hypoxia significantly inhibits photodynamic therapy's antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria developed based the light-activated alkyl free-radical generation (that independent). According to polydopamine-coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was...
The integration of 3D bioprinting and stem cells is great promise in facilitating the reconstruction cranial defects. However, effectiveness scaffolds has been hampered by limited cell behavior functions. Herein, a therapeutic cell-laden hydrogel for bone regeneration therefore developed through design void-forming hydrogel. This prepared digital light processing (DLP)-based marrow (BMSCs) mixed with gelatin methacrylate (GelMA)/dextran emulsion. 3D-bioprinted can not only promote...
Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be a featured salivary biomarker for discriminating periodontitis in presence diabetes. This study aimed explore whether macrophage plays role development diabetes mellitus-periodontitis, as well potential therapeutic strategies. By establishing model experimental mellitus-periodontitis rats, we found that IL-1β and gasdermin D were highly expressed, leading aggravated destruction periodontal tissue....
Background: The limited regenerative potential of periodontal tissue remains a challenge in orthodontic treatment, especially with respect to alveolar bone remodeling. dynamic balance between the formation osteoblasts and resorption osteoclasts controls homeostasis. osteogenic effect low-intensity pulsed ultrasound (LIPUS) is widely accepted, so LIPUS expected be promising method for regeneration. Osteogenesis regulated by acoustic mechanical LIPUS, while cellular perception, transduction...
Abstract Background The aim of this study is to conduct a comparative evaluation different designs clear aligners and examine the disparities between fixed appliances. Methods 3D digital models were created, consisting maxillary dentition without first premolars, maxilla, periodontal ligaments, attachments, micro-implant, printed lingual retractor, brackets, archwire aligner. involved creation five design for aligner anterior internal retraction one model appliance retraction, which...
Background Deficits in ambulatory function progress at heterogeneous rates among individuals with Duchenne muscular dystrophy (DMD). The resulting inherent variability outcomes has complicated the design of drug efficacy trials and clouded interpretation trial results. We developed a prediction model for 1-year change six minute walk distance (6MWD) DMD patients, compared its predictive value to that commonly used prognostic factors (age, baseline 6MWD, steroid use). Methods Natural history...
Automotive cyber-physical systems are energy-aware and safety-critical where energy consumption should be controlled from a perspective of design constraints reliability enhanced toward functional safety goal assurance. In this paper, we solve the problem enhancement an automotive function (i.e., functionality or application) under response-time based on dynamic voltage frequency scaling technique. The is solved by two-stage solution, namely, reduction constraint constraints. first stage...
Abstract Early childhood caries (ECC) is the most common chronic disease in young children. Its reported prevalence varies greatly across China. This systematic review aimed to explore epidemiological characteristics of ECC mainland China from 1987 2013. In total, 102 articles were included. The pooled national and care index (ft/dmft%) for 65.5% 3.6%, respectively. overall declined 77.9% during 1987–1994 56.4% 2010–2013. children aged 1–6 years was 0.3%, 17.3%, 40.2%, 54.4%, 66.1% 70.7%,...
DICER is the central enzyme that cleaves precursor microRNAs (miRNAs) into 21-25 nucleotide duplex in cell lineage differentiation, identity, and survival. In current study, we characterized specific bone metabolism genes corresponding miRNAs found Runt-related transcription factor 2 (Runx2) expressions increased simultaneously during osteogenic differentiation. Luciferase assay showed Runx2 significantly expression levels of luciferase promoter reporter. Our analysis also revealed weaker...
Abstract Background and Aims Follistatin-like protein-1 (FSTL-1) is considered to be an adipokine or myokine that could a potential regulator of metabolism. Our purpose investigate the relationship between circulating FSTL-1 levels insulin resistance (IR) in type 2 diabetes mellitus (T2DM) identify regulatory factors. Methods expression C57BL/6J db/db mice was examined by quantitative reverse transcriptase–polymerase chain reaction (qRT-PCR) Western blots. Serum were measured enzyme-linked...