A5061395897- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Dental Implant Techniques and Outcomes
- Polymer Surface Interaction Studies
- Smart Grid and Power Systems
- Endodontics and Root Canal Treatments
- Periodontal Regeneration and Treatments
- Advanced Drug Delivery Systems
- Oral and gingival health research
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- MXene and MAX Phase Materials
- Electrospun Nanofibers in Biomedical Applications
- Electricity Theft Detection Techniques
- Mesenchymal stem cell research
- Surgical Sutures and Adhesives
- Radiomics and Machine Learning in Medical Imaging
- Smart Grid Energy Management
- Cancer, Hypoxia, and Metabolism
- Quantum optics and atomic interactions
- Transplantation: Methods and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Hydraulic flow and structures
- Hemostasis and retained surgical items
Sichuan University
2012-2025
State Key Laboratory of Oral Diseases
2016-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Quzhou City People's Hospital
2024
Dalian Medical University
2024
Stomatological Hospital of Chongqing Medical University
2020-2023
Chongqing Medical University
2020-2023
Xiangya Hospital Central South University
2023
Central South University
2023
University of Kentucky
2022
The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation, reactive oxygen species (ROS), and overexpression proteinases (such matrix metalloproteinases, MMPs). A "diagnostic" therapeutic dual-logic-based hydrogel for therefore developed through design a double-network consisting phenylboronic-acid-crosslinked poly(vinyl alcohol) gelatin colloids. It exhibits logic to interpret pathological cues (glucose ROS, MMPs)...
Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for defect reconstructive treatment, especially graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol–chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the environment, ensure blood supply, promote osteogenic differentiation, accelerate reconstruction. Characterizations confirmed...
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong to tissues (up 38.72 ± 10.94 kPa). We also demonstrate mechanism relies on both physical association covalent bonding between mucus. Additionally, incorporated...
The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases (such as matrix metalloproteinases, MMPs), etc. In view the fact that exosomes represent a promising nanomaterial, herein, we reported excellent capacity stem cells from apical papilla-derived (SCAP-Exo) to facilitate angiogenesis osteogenesis whether normal or diabetic conditions vitro. Then, bioresponsive polyethylene...
Abstract Currently used wound dressings are ineffective. Hence, there is a need to develop introduce high‐performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity meet the growing worldwide demand for healing products. Here, inspired by strong adhesion of mussels enzyme‐mimicking nanometallic biomaterials, authors developed an injectable hydrogel overcome limitations current dressings. The synthesized via esterification reaction between...
Omentum metastasis is a common occurrence in epithelial ovarian cancer (EOC), which often accompanied by ascites that facilitates the spread of EOC cells. A subpopulation fibroblasts-the cancer-associated fibroblasts (CAFs) are important promoters tumor progression. We have shown previously CAFs exist not only omentum with but also without metastasis. In present study, using primary human isolated from normal (NFs) and (CAFs), we established vitro coculture models 3D culture model mimicking...
Abstract As a new class of crystalline nanoporous materials, metal‐organic frameworks (MOFs) have recently been used for biomedical applications due to their large surface area, high porosity, and theoretically infinite structures. To improve the biological performance titanium, MOF films were applied modification titanium. Zn‐based composed zeolitic imidazolate framework‐8 (ZIF‐8) crystals with nanoscale microscale sizes (nanoZIF‐8 microZIF‐8) prepared on porous titanium surfaces by...
Abstract Risk of implant failure increases profoundly in patients with pre‐existing conditions (e.g., diabetes). Current therapies adopt a one‐sided focus on the direct antibacterial properties biomaterials and osteogenesis stimulation. However, this study it is demonstrated that “chain armor” structure (Ce‐TA) mainly targets regulation local pathological microenvironment, provides novel solution to scavenge reactive oxygen species (ROS) by simulating superoxide dismutase catalase...
Periodontitis is an inflammatory disease characterized by tooth loss and alveolar bone resorption. Bacteria are the original cause of periodontitis, excess reactive oxygen species (ROS) encourage intensify inflammation. In this study, a mussel-inspired MnO2 NPs-reinforced adhesive hydrogel capable alleviating periodontitis with improved antibacterial antioxidant abilities was developed. The created combining polyvinyl alcohol (PVA), 3,4-dihydroxy-d-phenylalanine (DOPA), nanoparticles (NPs)...
Abstract Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting‐edge glue developed in this study satisfies these criteria. Inspired by excellent adhesive properties of mussels, herein, super (L‐DPZ) that integrates poly(vinyl alcohol), L‐dopa amino acid, zeolitic imidazolate framework‐8 characterized catechol–metal coordination is used successfully adhere hard with...
The interaction between an electric field and the energy levels of Rydberg states results in Stark effect, which can be used for quantum detection by measuring frequency shift EIT (Electromagnetically Induced Transparency) spectra. By leveraging functional relationship field, it is possible to measure question. However, when mismatch probe laster polarisation direction coupled leads errors measurement shift, turn affects accurate field. In this paper, Schrödinger equation firstly solved...
Abstract: Neurodegenerative diseases represent a prevalent category of age-associated diseases. As human lifespans extend and societies become increasingly aged, neurodegenerative pose growing threat to public health. The lack effective therapeutic drugs for both common rare amplifies the medical challenges they present. Current treatments these primarily offer symptomatic relief rather than cure, underscoring pressing need develop efficacious interventions. Drug repositioning, an innovative...
Autophagy is a pathophysiological phenomenon in liver cirrhosis that can further progress into hepatocarcinoma. Liver cancer stem cells (CSCs) are believed to initiate hepatocarcinogenesis. To investigate the precise mechanism related origin of CSCs and hepatocarcinogenesis, we labeled Axin2+ hepatic with EGFP Axin2Cre;Rosa26EGFP transgenic rats, then stratified clinical rat samples by autophagy flux. Clinical follow-up lineage tracing revealed while Axin2/EGFP+ were present normal livers...
Since the microgap between implant and surrounding connective tissue creates pass for pathogen invasion, sustained pathological stimuli can accelerate macrophage-mediated inflammation, therefore affecting peri-implant regeneration aggravate peri-implantitis. As transmucosal component of implant, abutment needs to be biofunctionalized repair gingival barrier. Here, a mussel-bioinspired coating containing tannic acid (TA), cerium minocycline (TA-Ce-Mino) is reported. TA provides pyrogallol...
Transplant arteriosclerosis is a leading cause of late allograft loss. Medial smooth muscle cell (SMC) apoptosis considered to be an important event in transplant arteriosclerosis. However, the precise contribution medial SMC and underlying mechanisms remain unclear. We transferred wild-type p53 induce cultured SMCs. found that induces production SDF-1α from apoptotic neighboring viable cells, resulting increased culture media. Conditioned media Ltv-p53-transferred SMCs activated...
Irrigation is considered to be a critical part of root canal treatment. However, little known about the effect needle movement on irrigation process. Therefore, this study aimed investigate influence syringe and using three-dimensional computational fluid dynamics (CFD) numerical model. The CFD codes Flow-3D was adopted simulate process with moving up down in motions at different amplitudes frequencies. One stationary allow comparison needles up-and-down motions. Six cases where were...
In the present study, a cell-penetrating peptide, transactivating transcriptional factor (TAT) domain from HIV, was linked to PEGylated multi-walled carbon nanotubes (MWCNTs) develop highly effective antitumor drug delivery system. FITC conjugated on MWCNTs-polyethylene glycol (PEG) and MWCNTs-PEG-TAT provide fluorescence signal for tracing cellular uptake of nanocarrier. After loaded with an anticancer agent, doxorubicin (DOX) via π - stacking interaction, physicochemical characteristics,...
Endoscopic ultrasound (EUS) is vital for early pancreatic cancer diagnosis. Advances in artificial intelligence (AI), especially deep learning, have improved medical image analysis. We developed and validated the Modified Faster R-CNN (M-F-RCNN), an AI algorithm using EUS images to assist diagnosing cancer.
Stiff person syndrome (SPS) is a rare disease characterized by axial and lower-extremity muscle rigidity, spasm, pain. Progressive encephalomyelitis with rigidity myoclonus (PERM) variant of SPS. This case particularly notable for its uncommon initial symptom: orthostatic hypotension, coupled the presence multiple antibodies. Such presentation rarity in context PERM, thus providing fresh unique angle both diagnosis treatment.