A5100357758- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
- Esophageal Cancer Research and Treatment
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Orthopedic Infections and Treatments
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related gene regulation
- Infectious Diseases and Tuberculosis
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
Chongqing Medical University
2015-2025
Stomatological Hospital of Chongqing Medical University
2018-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2025
Changzhou Vocational Institute of Light Industry
2025
Fourth Hospital of Changsha
2018-2025
Shanghai East Hospital
2022-2025
Air Force Medical University
2011-2024
Xi’an Children’s Hospital
2024
Huazhong Agricultural University
2019-2024
Tianjin Medical University
2012-2024
With the blossoming of network functions virtualization and software-defined networks, networks are becoming more agile with features like resilience, programmability, open interfaces, which help operators to launch a or service flexibility shorter time market. Recently, concept slicing has been proposed facilitate building dedicated customized logical virtualized resources. In this article, we introduce hierarchical NSaaS, helping offer end-to-end cellular as service. Moreover,...
The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation, reactive oxygen species (ROS), and overexpression proteinases (such matrix metalloproteinases, MMPs). A "diagnostic" therapeutic dual-logic-based hydrogel for therefore developed through design a double-network consisting phenylboronic-acid-crosslinked poly(vinyl alcohol) gelatin colloids. It exhibits logic to interpret pathological cues (glucose ROS, MMPs)...
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong to tissues (up 38.72 ± 10.94 kPa). We also demonstrate mechanism relies on both physical association covalent bonding between mucus. Additionally, incorporated...
The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases (such as matrix metalloproteinases, MMPs), etc. In view the fact that exosomes represent a promising nanomaterial, herein, we reported excellent capacity stem cells from apical papilla-derived (SCAP-Exo) to facilitate angiogenesis osteogenesis whether normal or diabetic conditions vitro. Then, bioresponsive polyethylene...
To parallelly compare the efficacy of neoadjuvant immunotherapy (tislelizumab), chemotherapy (gemcitabine and cisplatin), combination therapy (tislelizumab + GC) in patients with muscle-invasive bladder cancer (MIBC) explore predictors, we perform a multi-center, real-world cohort study that enrolls 253 treated treatments (combination therapy: 98, chemotherapy: 107, immunotherapy: 48) from 15 tertiary hospitals. We demonstrate achieves highest complete response rate pathological downstaging...
Abstract Currently used wound dressings are ineffective. Hence, there is a need to develop introduce high‐performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity meet the growing worldwide demand for healing products. Here, inspired by strong adhesion of mussels enzyme‐mimicking nanometallic biomaterials, authors developed an injectable hydrogel overcome limitations current dressings. The synthesized via esterification reaction between...
Hydrogels that are capable of wet adhesion and self-healing can enable major advances in a variety biomedical applications such as tissue regeneration, wound dressings, wearable/implantable devices, drug delivery. We hereby developed an innovative but simple strategy to achieve adhesive, self-healing, highly stretchable double-network hydrogels, which were composed primary covalent polyethylene glycol diacrylate (PEGDA) network combination with noncovalent diffusive, giant PEG chains. The...
Bone healing is a dynamic process regulated by biochemical signals such as chemokines and growth factors, biophysical topographical mechanical features of extracellular matrix or stimuli. Hereby, mechanically tough bioactive hydrogel based on autologous injectable platelet-rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) developed. This composite demonstrates double network (DN) mechanism, wherein covalent serves to maintain material integrity, self-assembled colloidal GNPs...
SsITL, a secretory protein of the necrotrophic phytopathogen Sclerotinia sclerotiorum, was previously reported to suppress host immunity at early stages infection. However, molecular mechanism that SsITL uses inhibit plant defence against S. sclerotiorum has not yet been elucidated. Here, we report interacted with chloroplast-localized calcium-sensing receptor, CAS, in chloroplasts. We found CAS is positive regulator salicylic acid signalling pathway and CAS-mediated resistance depends on...
Abstract Risk of implant failure increases profoundly in patients with pre‐existing conditions (e.g., diabetes). Current therapies adopt a one‐sided focus on the direct antibacterial properties biomaterials and osteogenesis stimulation. However, this study it is demonstrated that “chain armor” structure (Ce‐TA) mainly targets regulation local pathological microenvironment, provides novel solution to scavenge reactive oxygen species (ROS) by simulating superoxide dismutase catalase...
Abstract To date, hydrogen (H 2 ) therapy has received widespread attention. However, X‐ray triggered sustainable H ‐producing materials with controlled release for cancer treatment have not been reported. Herein, an in situ producing platform, Au NR‐TiO @ZnS:Cu,Co‐A(Au‐TiO @ZnS), composed of Au‐amorphous TiO nano‐dumbbell‐shaped heterostructure coated long afterglow particles, was developed synergistic ‐radiotherapy. The mechanism production verified by theoretical calculations and vitro...
Abstract Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate (4-OI) cell-permeable derivative has been recognized as promising therapeutic target for treatment inflammatory diseases. Here, we explored, first time, protective effect 4-OI on inhibiting destruction, ameliorating local inflammation, underlying mechanism in periodontitis....
Autophagy is an important protective mechanism in maintaining or restoring cell homeostasis under physiological and pathological conditions. Nanoparticles (NPs) with certain components morphologies can induce autophagic responses cancer cells, providing a new perspective for establishing therapy strategies. Herein, novel nanodrug system, membranes-coated zeolitic imidazolate framework-8 (ZIF-8) NPs encapsulating chloroquine (CQ) glucose oxidase (GOx) (defined as mCG@ZIF), designed to achieve...
Periodontitis is an inflammatory disease characterized by tooth loss and alveolar bone resorption. Bacteria are the original cause of periodontitis, excess reactive oxygen species (ROS) encourage intensify inflammation. In this study, a mussel-inspired MnO2 NPs-reinforced adhesive hydrogel capable alleviating periodontitis with improved antibacterial antioxidant abilities was developed. The created combining polyvinyl alcohol (PVA), 3,4-dihydroxy-d-phenylalanine (DOPA), nanoparticles (NPs)...
Abstract Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting‐edge glue developed in this study satisfies these criteria. Inspired by excellent adhesive properties of mussels, herein, super (L‐DPZ) that integrates poly(vinyl alcohol), L‐dopa amino acid, zeolitic imidazolate framework‐8 characterized catechol–metal coordination is used successfully adhere hard with...
Infected bone defects (IBDs) exhibit impaired healing due to excessive inflammation triggered by pathogen-associated molecular patterns (PAMPs) from bacteria. As a vital factor in orchestrating immune responses, mitochondrial homeostasis maintenance is central blockade. This research developed chameleon-like nanoplatform covering hydroxyapatite nanoparticles with cerium ion coordinated tannic acid supramolecular network (HA@Ce-TA), which adaptively functions regulate based on intra- and...
Photothermal therapy (PTT) demonstrates significant potential in cancer treatment, wound healing, and antibacterial therapy, with its efficacy largely depending on the performance of photothermal agents (PTAs). Metal‐phenolic network (MPN) materials are ideal PTA candidates due to their low cost, good biocompatibility excellent ligand‐to‐metal charge transfer properties. However, not all MPNs exhibit properties, vast chemical space (over 700,000 combinations) complicates screening...
As a promiscuous xenobiotic sensor, the constitutive androstane receptor (CAR; NR1I3) regulates expression of multiple drug-metabolizing enzymes and transporters in liver. The constitutively activated nature CAR cell-based transfection assays has hindered its use as predictor metabolism-based drug-drug interactions. Here, we have identified 1-(2-chlorophenylmethylpropyl)-3-isoquinoline-carboxamide (PK11195), typical peripheral benzodiazepine (PBR) ligand, selective potent inhibitor human (h)...
The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes osteogenic-related cells resulting in inflammatory response tissue healing. healing phase can be influenced various environmental factors biological cascade effect. To synthetically orchestrate bone-promoting on biomaterial surface, built a dual delivery system coated titanium surface (abbreviated as AH-Sr-AgNPs). results show that this...
Level-specific lumbar bone mineral density (BMD) evaluation of a single vertebral body can provide useful surgical planning and osteoporosis management information. Previous comparative studies have primarily focused on detecting spinal but not at specific levels.To compare the detection rate between quantitative computed tomography (QCT) dual-energy X-ray absorptiometry (DXA); to explore analyze distribution models QCT-derived BMD DXA T-score levels; evaluate diagnostic accuracy...
The healing of infected bone defects (IBD) is a complex physiological process involving series spatially and temporally overlapping events, including pathogen clearance, immunological modulation, vascularization, osteogenesis. Based on the theory that regulated by both biochemical biophysical signals, in this study, copper doped bioglass (CuBGs)/methacryloyl-modified gelatin nanoparticle (MA-GNPs)/methacrylated silk fibroin (SilMA) hybrid hydrogel developed to promote IBD healing. This...