A5100772628- Oral microbiology and periodontitis research
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Studies
- Fatty Acid Research and Health
- Neuroscience and Neuropharmacology Research
- Periodontal Regeneration and Treatments
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Advanced Nanomaterials in Catalysis
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
- Bone Tissue Engineering Materials
- Alzheimer's disease research and treatments
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Ectopic Pregnancy Diagnosis and Management
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Reproductive tract infections research
- Lung Cancer Treatments and Mutations
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
Harbin Institute of Technology
2025
Zhejiang Chinese Medical University
2023-2025
Guangdong Provincial People's Hospital
2024
Institute of Process Engineering
2021-2024
University of Chinese Academy of Sciences
2023-2024
Shanghai Jiao Tong University
2013-2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2017-2024
Guangzhou University of Chinese Medicine
2024
Shenzhen Chipscreen Biosciences Co.
2019-2024
Abstract Background Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During progression, abnormally phosphorylated forms tau aggregate accumulate into neurofibrillary tangles, leading to synapse loss, neuroinflammation, neurodegeneration. Thus, targeting expected be promising strategy for AD treatment. Methods The effect rutin on aggregation was detected by thioflavin T fluorescence transmission electron microscope imaging. oligomer-induced cytotoxicity assessed...
Background and Aims HSCs portal fibroblasts (PFs) are the major sources of collagen‐producing myofibroblasts during liver fibrosis, depending on different etiologies. However, mechanisms by which their dynamic gene expression directs transition from quiescent to activated state—as well as contributions fibrotic myofibroblasts—remain unclear. Here, we analyze activation PFs in CCL 4 ‐induced bile duct ligation–induced fibrosis mouse models, using single‐cell RNA sequencing lineage tracing....
Abstract Currently used wound dressings are ineffective. Hence, there is a need to develop introduce high‐performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity meet the growing worldwide demand for healing products. Here, inspired by strong adhesion of mussels enzyme‐mimicking nanometallic biomaterials, authors developed an injectable hydrogel overcome limitations current dressings. The synthesized via esterification reaction between...
Periodontitis is an inflammatory disease characterized by tooth loss and alveolar bone resorption. Bacteria are the original cause of periodontitis, excess reactive oxygen species (ROS) encourage intensify inflammation. In this study, a mussel-inspired MnO2 NPs-reinforced adhesive hydrogel capable alleviating periodontitis with improved antibacterial antioxidant abilities was developed. The created combining polyvinyl alcohol (PVA), 3,4-dihydroxy-d-phenylalanine (DOPA), nanoparticles (NPs)...
The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes osteogenic-related cells resulting in inflammatory response tissue healing. healing phase can be influenced various environmental factors biological cascade effect. To synthetically orchestrate bone-promoting on biomaterial surface, built a dual delivery system coated titanium surface (abbreviated as AH-Sr-AgNPs). results show that this...
Bone targeting is one of the most potentially valuable therapeutic methods for medically treating bone diseases, such as osteoarthritis, osteoporosis, nonunion defects, cancer, and myeloma-related disease, but its efficacy remains a challenge due to unfavorable biodistribution, off-target effects, lack cell specificity. To address these problems, we synthesized new dual-targeting nanocarrier delivery by covalently modifying G4.0 PAMAM dendrimer with C11 peptide CH6 aptamer (CH6-PAMAM-C11)....
Fear extinction is an evolutionarily conserved biological process that allows organism to better re-adapt; its deficits can lead psychiatric disorders. considered rely mostly on neuronal function. However, whether and how astrocytes contribute fear largely unknown. Here, we show hippocampal CA1 exhibit de novo Ca 2+ dynamics during extinction. Inhibition of these astrocytic impairs, while their activation facilitates, In this regulation extinction, the posterior basal forebrain (pBF)...
Mariculture wastewater is an intractable wastewater, owing to its high salinity inhibiting microbial metabolism. The biocarrier bacterial–microbial consortium (BBM) and (BM) were developed investigate the mechanism of pollutant degradation community evolution. BBM exhibited excellent mariculture treatment, with highest removal for TOC (91.78%), NH4+-N (79.33%) PO43−-P (61.27%). Biocarriers accelerated anaerobic region formation, levels denitrifying bacteria accumulation improving nitrogen in...
Abstract Background Brain metastasis (BM) are a devastating consequence of lung cancer. This study was aimed to screen risk factors for predicting BM. Methods Using an in vivo BM preclinical model, we established series adenocarcinoma (LUAD) cell subpopulations with different metastatic ability. Quantitative proteomics analysis used and identify the differential protein expressing map among subpopulation cells. Q-PCR Western-blot were validate proteins vitro. The candidate measured LUAD...
Human periodontal ligament stem cells (hPDLSCs) sheets play an important role in tissue engineering. Low-intensity pulsed ultrasound (LIPUS) has been reported as effective stimulus to regulate cell biological behavior. The present study aims explore the potential of LIPUS promote formation and function hPDLSC (hPDLSCSs). Hematoxylin-eosin (H&E) staining, western blot, real-time PCR, alkaline phosphatase (ALP), alizarin red staining were used evaluate osteogenic effect on hPDLSCSs vitro....
STK40 is a putative serine/threonine kinase and was shown to induce extraembryonic endoderm differentiation from mouse embryonic stem cells. However, little known about its physiological function <i>in vivo</i>. Here, we generate <i>Stk40</i> knock-out mice demonstrate that loss of the gene causes neonatal lethality at birth. Further examination reveals respiratory distress atelectasis occur in homozygous mutants. The maturation lung alveolar epithelium delayed mutant, as indicated by...
The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development contributes to exhaustion, thereby causing defective tumor immunity deficient responses older adults who have increased expression. Tuning enzymatic activity targeting transcriptional regulation ENTPD1 can be used modulate signaling. Here, we describe that STAT6 phosphorylation downstream IL-4...
A 76-year-old woman has got both lower limbs petechia and ecchymosis for 1 month, edema 6 days fever 3 days. The patient suffered from purpura of limbs, edema, arthralgia, recurrent fever, kidney damages, serositis, progressive
Amyloid-β (Aβ) plays an important role in the neuropathology of Alzheimer's disease (AD), but some factors promoting Aβ generation and oligomer (Aβo) neurotoxicity remain unclear. We here find that levels ArhGAP11A, a Ras homology GTPase-activating protein, significantly increase patients with AD amyloid precursor protein (APP)/presenilin-1 (PS1) mice. Reducing ArhGAP11A level neurons not only inhibits by decreasing expression APP, PS1, β-secretase (BACE1) through RhoA/ROCK/Erk signaling...
Abstract The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but factors affecting α-syn generation neurotoxicity remain unclear. We here first found that thrombomodulin (TM) significantly decreased plasma PD patients brains A53T mice, increased TM primary neurons reduced by inhibiting transcription factor p-c-jun production through Erk1/2 signaling pathway. Moreover, reducing levels oxidative stress PAR1-p53-Bax...
Temporomandibular joint (TMJ) osteoarthritis (OA) affects millions of people worldwide, characterized by imbalance metabolism, excess reactive oxygen species (ROS), aberrant epigenetic alterations and so on. Currently, analgesics anti-inflammatory drugs are mainly used for treatment, but they only alleviate symptoms. Here, we designed a ultrasmall copper-based nanoclusters agent (copper iodide coordination, Cu2I2), which exhibited remarkable ROS-scavenging activities. And the antioxidant...