A5100430427- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Mast cells and histamine
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Amino Acid Enzymes and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- EEG and Brain-Computer Interfaces
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
Zhejiang University
2016-2025
Zhejiang Chinese Medical University
2015-2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Affiliated Hospital of Nantong University
2009-2025
Nantong University
2015-2025
Huzhou Central Hospital
2025
Southern Illinois University School of Medicine
2024
Southern Medical University
2010-2024
Augusta University
2002-2024
Loma Linda University
2020-2024
By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV-2) invades host cells and affects many organs, including brain. However, distribution of ACE2 in brain is still obscure. Here, we investigated expression by analyzing data from publicly available transcriptome databases. According to our spatial analysis, was relatively highly expressed some locations, such as choroid plexus paraventricular nuclei thalamus....
Cerebral ischemia-reperfusion (I-R) is a complex pathological process. Although autophagy can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and contribution to fate of neurons remains largely unknown. In present investigation, we found that was activated phase, as revealed both mice with middle cerebral artery occlusion oxygen-glucose deprived cortical culture. Interestingly, contrast permanent inhibition (by 3-methyladenine, bafilomycin A1, Atg7 knockdown or...
Highlights•SCCs show chromosome or methylation alterations affecting multiple related genes•These regulate squamous stemness, differentiation, growth, survival, and inflammation•Copy-quiet SCCs have hypermethylated (FANCF, TET1) mutated (CASP8, MAPK-RAS) genes•Potential targets include ΔNp63, WEE1, IAPs, PI3K-mTOR/MAPK, immune responsesSummaryThis integrated, multiplatform PanCancer Atlas study co-mapped identified distinguishing molecular features of cell carcinomas (SCCs) from five sites...
Transient cerebral ischemia leads to endoplasmic reticulum (ER) stress. However, the contributions of ER stress are not clear. To address this issue, activators tunicamycin (TM) and thapsigargin (TG) were administered transient middle artery occluded (tMCAO) mice oxygen-glucose deprivation-reperfusion (OGD-Rep.)-treated neurons. Both TM TG showed significant protection against ischemia-induced brain injury, as revealed by reduced infarct volume increased glucose uptake rate in ischemic...
Cerebral ischemia induces massive mitochondrial damage. These damaged mitochondria are cleared, thus attenuating brain injury, by mitophagy. Here, we identified the involvement of BNIP3L/NIX in cerebral ischemia-reperfusion (I-R)-induced Bnip3l knockout (bnip3l-/-) impaired mitophagy and aggravated I-R injury mice, which can be rescued BNIP3L overexpression. The rescuing effects overexpression observed park2-/- showed deficiency after I-R. Interestingly, bnip3l park2 double-knockout mice a...
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment myeloid-derived suppressor cells (MDSC) into tumor microenvironment. Here we demonstrate functional inhibition MDSC with IPI-145, inhibitor PI3Kδ PI3Kγ isoforms, which enhances responses PD-L1 blockade. Combination therapy induced CD8
Abstract By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic SARS-coronavirus (SARS-CoV-2) may invade host cells in many organs, including brain. However, distribution of ACE2 brain is still obscure. Here we investigated expression by analyzing data from publicly available transcriptome databases. According to our spatial analysis, was relatively highly expressed some locations, such as choroid plexus and paraventricular nuclei thalamus. cell-type nuclear found...
Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of homeostasis2, it remains elusive whether and how autophagy is engaged dynamics. Here we discover that acute activates, whereas chronic suppresses, mainly the lateral habenula (LHb). Systemic administration distinct antidepressant drugs similarly restores function LHb, suggesting LHb as common target. Genetic ablation neuronal promotes susceptibility, enhancing exerts...
Abstract —Atherosclerotic coronary heart disease is a common complication of the insulin resistance syndrome that can occur with or without diabetes mellitus. Thiazolidinediones (TZDs), which are insulin-sensitizing antidiabetic agents, modulate development atherosclerosis not only by changing systemic metabolic conditions associated but also exerting direct effects on vascular wall cells express peroxisome proliferator–activated receptor-γ (PPAR-γ), nuclear receptor for TZDs. Here we show...
// Jinjin Lu 1 , Xiufen Zheng 2 Fan Li Yang Yu 3 Zhong Chen Liu Zhihua Wang Hua Xu Weimin Department of Urology, Tongji Hospital, Medical College, Huazhong University Science and Technology, Wuhan, 430030, P. R. China Pathology, Oncology, Surgery, Western University, Lawson Health Research Institute, London, Ontario, N6A 5A5, Canada Ultrasound, Correspondence to: Li, email: fanli117@hotmail.com Keywords: tunneling nanotubes, mitochondria, bladder cancer, cell invasion, connection Received:...
Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal survival in cerebral ischemia. Previous studies found deficient mitophagy ischemic neurons, but mechanisms are still largely unknown. We determined that BNIP3L/NIX, a receptor, was degraded by proteasomes, which led to deficiency both neurons and brains. BNIP3L exists as monomer homodimer mammalian cells, effects on unclear. Site-specific mutations transmembrane domain (S195A G203A) only formed failed...
// Yu Hu 1,* , Xia-Chun Li Zhi-hao Wang 1 Luo Xiangnan Zhang 2 Xiu-Ping Liu Qiong Feng Qun Zhenyu Yue 3 Zhong Chen Keqiang Ye 4 Jian-Zhi 1,5 and Gong-Ping Department of Pathophysiology, School Basic Medicine The Collaborative Innovation Center for Brain Science, Key Laboratory Ministry Education China Neurological Disorders, Tongji Medical College, Huazhong University Science Technology, Wuhan, Pharmacology, College Pharmaceutical Sciences, Zhejiang University, Hangzhou, Departments...
The lateral parabrachial nucleus (LPBN) is known to relay noxious information the amygdala for processing affective responses. However, it unclear whether LPBN actively processes neuropathic pain characterized by persistent hyperalgesia with aversive emotional Here we report that pain-like hypersensitivity induced common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic neurons. Optogenetic activation of GABAergic neurons does not affect basal...
Abstract Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading synapse dysfunction in Alzheimer’s disease (AD). In the present study, we report that probability (Pr) at between Schaffer collateral (SC) and CA1 pyramidal neurons significantly reduced an stage mouse models of AD with elevated Aβ production. High nanomolar synthetic oligomeric 42 also suppresses Pr SC-CA1 wild-type mice. This Aβ-induced suppression mainly due...
Prompt reperfusion after cerebral ischemia is critical for neuronal survival. Any strategies that extend the limited window will be of great importance. Acidic postconditioning (APC) a mild acidosis treatment involves inhaling CO2 during following ischemia. APC attenuates ischemic brain injury although underlying mechanisms have not been elucidated. Here we report reinforces ischemia-reperfusion-induced mitophagy in middle cortical artery occlusion (MCAO)-treated mice, and oxygen-glucose...
Astrocytes are critical in synapse development, and their dysfunction crucial developmental stages leads to serious neurodevelopmental diseases, including seizures epilepsy. Immune challenges not only affect brain but also promote seizure generation epileptogenesis, implying immune activation is one of the key factors linking epilepsy abnormal development. In this study, we report that activating astrocytes by systemic lipopolysaccharide (LPS) second postnatal week promotes excitatory...