A5029627298- Software Engineering Research
- Software System Performance and Reliability
- Software Reliability and Analysis Research
- Alzheimer's disease research and treatments
- Advanced Software Engineering Methodologies
- Software Engineering Techniques and Practices
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Distributed and Parallel Computing Systems
- Pregnancy and preeclampsia studies
- Smart Grid and Power Systems
- Advanced Malware Detection Techniques
- Software Testing and Debugging Techniques
- Scientific Computing and Data Management
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Endodontics and Root Canal Treatments
- Histone Deacetylase Inhibitors Research
- Oral microbiology and periodontitis research
- Data Quality and Management
Guangzhou Medical University
2010-2025
North China Electric Power University
2020-2025
China Electric Power Research Institute
2020-2025
Nanjing University of Science and Technology
2021-2024
Huazhong University of Science and Technology
2014-2023
Wuhan Children's Hospital
2018-2023
Second Xiangya Hospital of Central South University
2005-2023
Central South University
2005-2023
Hainan University
2021
The First Affiliated Hospital, Sun Yat-sen University
2020
Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, reverse role of MAPT accumulation autophagy neurodegeneration is not clear. Here, we found that overexpression human wild-type full-length MAPT, which models pathologies as seen sporadic AD patients, induced deficits via repression autophagosome-lysosome fusion leading to significantly increased LC3 (microtubule-associated protein 1...
Although effects of weather changes on human health have been widely reported, there is limited information regarding pregnant women in developing countries.We investigated the association between maternal exposure to ambient temperature and risk preterm birth (< 37 weeks gestation) Guangzhou, China.We used a Cox proportional hazards model estimate associations average during each week gestation, with weekly modeled as time-varying four time windows: 1 (the last pregnancy), 4 late pregnancy...
Abstract Intracellular accumulation of tau protein is hallmark sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby causes neurodegeneration poorly understood. Here we report that overexpression human wild-type full-length (termed htau) disrupted mitochondrial dynamics by enhancing fusion and induced their perinuclear in HEK293 cells rat primary hippocampal neurons. The htau at later stage inhibited functions shown decreased ATP level, ratio ATP/ADP complex I activity....
// Yu Hu 1,* , Xia-Chun Li Zhi-hao Wang 1 Luo Xiangnan Zhang 2 Xiu-Ping Liu Qiong Feng Qun Zhenyu Yue 3 Zhong Chen Keqiang Ye 4 Jian-Zhi 1,5 and Gong-Ping Department of Pathophysiology, School Basic Medicine The Collaborative Innovation Center for Brain Science, Key Laboratory Ministry Education China Neurological Disorders, Tongji Medical College, Huazhong University Science Technology, Wuhan, Pharmacology, College Pharmaceutical Sciences, Zhejiang University, Hangzhou, Departments...
Our prior work showed that the majority of error-prone source files in a software system are architecturally connected. Flawed architectural relations propagate defects among these and accumulate high maintenance costs over time, just like debts interest. We model groups connected as debts. To quantify such debts, we formally define debt, show how to automatically identify their costs, time. describe novel history coupling probability matrix for this purpose, architecture using 4 patterns...
Our recent research has shown that, in large-scale software systems, defective files seldom exist alone. They are usually architecturally connected, and their architectural structures exhibit significant design flaws which propagate bugginess among files. We call these flawed the architecture roots, a type of technical debt that incurs high maintenance penalties. Removing roots requires refactoring, but benefits refactoring have historically been difficult for architects to quantify or...
Despite decades of research on software metrics, we still cannot reliably measure if one design is more maintainable than another. Software managers and architects need to understand whether their architecture "good enough", it decaying over time and, so, by how much. In this paper, contribute a new maintainability metric---Decoupling Level (DL)---derived from Baldwin Clark's option theory. Instead measuring coupled an is, well the can be decoupled into small independently replaceable...
Our recent research has shown that, in large-scale software systems, defective files seldom exist alone. They are usually architecturally connected, and their architectural structures exhibit significant design flaws which propagate bugginess among files. We call these flawed the architecture roots, a type of technical debt that incurs high maintenance penalties. Removing roots requires refactoring, but benefits refactoring have historically been difficult for architects to quantify or...
In large-scale software systems, error-prone or change-prone files rarely stand alone. They are typically architecturally connected and their connections usually exhibit architecture problems causing the propagation of error-proneness change-proneness. this paper, we propose empirically validate a suite anti-patterns that occur in all systems involved high maintenance costs. We define these based on fundamental design principles Baldwin Clark's rule theory. can automatically detect by...
The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer's disease (AD). In addition acetyltransferases (HATs) and deacetylases (HDACs), inhibitor (INHAT) can also regulate acetylation. As a key component INHAT, level ANP32A selectively upregulated brain AD patients. Here we investigated whether downregulating rescue AD-like synapse memory deficits.RFP-labeled lentiviral ANP32A-shRNA was infused stereotaxically into hippocampal CA3 region human tau...
To evaluate the first prospective screening program in China for control of alpha and beta-thalassemia population pregnant couples.During period between January 1993 December 2003, a hospital-based preventive was conducted at biggest birth center Guangzhou, with 1/17 all deliveries this city referred annually by use conventional heterozygote strategy combination system regular healthcare examination pregnancy.The screened records included 49 221 women, 4503 husbands women showed positive on...
Recently there has been increased attention to the consequences of architecture design decisions and their impact on security. Architectural have identified as being critical for achieving high levels software system However majority this research anecdotal are few tools or methods understanding architectural relations among files, In paper we employ a DRSpace-based analysis approach identify flaws show, via an empirical study 10 open source projects, that areas suffer from greater numbers...
In this paper, we propose an architecture model called Design Rule Space (DRSpace). We the of a software system as multiple overlapping DRSpaces, reflecting fact that any complex must contain aspects, features, patterns, etc. show provides new ways to analyze quality. particular, introduce Architecture Root detection algorithm captures DRSpaces containing large numbers project's bug-prone files, which are Roots (ArchRoots). After investigating ArchRoots calculated from 15 open source...
<h3>Objective</h3> To formulate a new birthweight reference for different gestational ages in Guangzhou, southern China, and compare it with the currently used China global reference. <h3>Design setting</h3> All singleton live births of more than 26 weeks' age recorded Guangzhou Perinatal Health Care Delivery Surveillance System years 2009, 2010 2011 (n=510 837) were retrospectively included study. In addition, study sample was supplemented by all (n=3538) at 26–33 weeks from 2007 2008. We...
To investigate the prevalence of adult-onset autoimmune diabetes (ADM) and predisposition to diseases by quantifying serum organ-specific autoantibodies in people with phenotype type 2 (T2D).We included a nationally representative sample 46 239 adults aged ≥20 years from 14 provinces, whom 4671 had diabetes, plus 1000 control subjects normal glucose tolerance (NGT). Participants were screened centrally for glutamic acid decarboxylase (GAD), islet antigen (IA2) zinc transporter isoform-8...
Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose this study was to compare the frequency pregnancy among syphilis-seropositive women who received different treatment regimens at times Guangzhou, China. Pregnant with syphilis infection prenatal and delivery services Guangzhou between January 2014 December 2016 were included. Association status composite (preterm birth, infant smaller than gestational age, stillbirth, spontaneous...
The prevalence of visual impairment (VS) among children in China is increasing. oral microbiome crucial for maintaining homeostasis and health. This study aimed to investigate the health hygiene habits with VS Guangzhou explore differences salivary microbiota (SM) between healthy vision (HS). included examinations surveys 101 VS. Saliva samples from 20 HS were analysed microbiota. 16s rRNA V3-V4 regions sequenced using Illumina MiSeq platform operational taxonomic units clustered QIIME...