A5034198553- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- vaccines and immunoinformatics approaches
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Medicinal Plants and Neuroprotection
- Diabetes and associated disorders
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Neurological disorders and treatments
- Prion Diseases and Protein Misfolding
- Aluminum toxicity and tolerance in plants and animals
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Nerve injury and regeneration
- interferon and immune responses
- Mitochondrial Function and Pathology
Institute of Process Engineering
2016-2025
Chinese Academy of Sciences
2015-2024
Tsinghua University
2009-2012
Abstract Background Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During progression, abnormally phosphorylated forms tau aggregate accumulate into neurofibrillary tangles, leading to synapse loss, neuroinflammation, neurodegeneration. Thus, targeting expected be promising strategy for AD treatment. Methods The effect rutin on aggregation was detected by thioflavin T fluorescence transmission electron microscope imaging. oligomer-induced cytotoxicity assessed...
Cancer immunotherapy efficacy is largely limited by the suppressive tumor immune microenvironment (TIME) where antitumor cells are inhibited and antigens continue to mutate or be lost. To remodel TIME, we here applied weakly alkaline layered double hydroxide nanoparticles (LDH NPs) neutralize excess acid block autophagy of for neoadjuvant cancer immunotherapy. Peritumoral injection LDH NPs provided a long-term efficient acid-neutralization in blocked lysosome-mediated pathway cells,...
Alzheimer's disease (AD) is the most common form of dementia, characterized by formation extracellular senile plaques and neuronal loss caused amyloid β (Aβ) aggregates in brains AD patients. Conventional strategies failed to treat clinical trials, partly due poor solubility, low bioavailability ineffectiveness tested drugs cross blood-brain barrier (BBB). Moreover, a complex, multifactorial neurodegenerative disease; one-target may be insufficient prevent processes AD. Here, we designed...
Resveratrol exerts neuroprotective effects on the A53T α-synuclein mouse model of Parkinson's disease.
Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on virus and their immunogenicity poorly understood. Here, we simulate 3D structures predict B cell spike (S), envelope (E), membrane (M), nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches validate epitope by immunizing mice. Almost all 33 predicted effectively induce antibody production, six these immunodominant in individuals, 23...
Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC through synergistically depleting endogenous glutathione (GSH) activating STING signaling pathway, but also facilitated the delivery of model ovalbumin (OVA) into lymph nodes subsequent in DCs. Significant...
Rutin inhibited amylin aggregation, amylin-induced neurocytotoxicity, and decreased the production of ROS, NO, GSSG, malondialdehyde pro-inflammatory cytokines.
Cancer recurrence and metastasis are worldwide challenges but current bimodular strategies such as combined radiotherapy chemotherapy (CTX), photothermal therapy (PTT) immunotherapy have succeeded only in some limited cases. Thus the present study, a multifunctional nanomedicine has been rationally designed via elegantly integrating three FDA-approved therapeutics, that is, indocyanine green (for PTT), doxorubicin CTX), CpG immunotherapy) into structure of layered double hydroxide (LDH)...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Diagnosing AD before symptoms arise will facilitate earlier intervention. The early diagnostic approaches are thus urgently needed.The multifunctional nanoparticles W20/XD4-SPIONs were constructed by conjugation oligomer-specific scFv antibody W20 class A scavenger receptor (SR-A) activator XD4 onto superparamagnetic iron oxide (SPIONs). SPIONs' stability uniformity in size measured...
Abstract Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease (AD). However, almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitive deficits AD animal models. Here, we showed that Aβ-targeting antibodies including their lgG1 lgG4 subtypes induced microglial engulfment neuronal synapses by activating CR3 or FcγRIIb via complex Aβ, antibody, complement. Notably, anti-Aβ without...
Synapse loss is one of the most critical features in Alzheimer’s disease (AD) and correlates with cognitive decline. Astrocytes mediate synapse elimination through multiple EGF-like domains 10 (MEGF10) pathways developing adult brain to build precise neural connectivity. However, whether how astrocytes AD remains unknown. We here find that phagocytic receptor MEGF10 significantly increased vivo vitro, which results excessive engulfment synapses by APP/PS1 mice. also observe astrocytic...
Abstract The elderly frequently present impaired blood–brain barrier which is closely associated with various neurodegenerative diseases. However, how the albumin, most abundant protein in plasma, leaking through disrupted BBB, contributes to neuropathology remains poorly understood. We here demonstrated that mouse serum albumin-activated microglia induced astrocytes A1 phenotype remarkably increase levels of Elovl1, an astrocytic synthase for very long-chain saturated fatty acids,...
Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs accumulation cytoplasm, which a hallmark multiple neurodegenerative diseases. Our previous study showed that neuronal DNase II drove tau hyperphosphorylation and neurodegeneration (Li et al., Transl Neurodegener 13:39, 2024). Although it has been verified participates type I interferons (IFN-I) mediated autoinflammation senescence peripheral systems, role microglial...