A5100664825- Alzheimer's disease research and treatments
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Osteoarthritis Treatment and Mechanisms
- Cholesterol and Lipid Metabolism
- Bone Metabolism and Diseases
- Histone Deacetylase Inhibitors Research
- Effects and risks of endocrine disrupting chemicals
- Fatty Acid Research and Health
- Animal Virus Infections Studies
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- SARS-CoV-2 and COVID-19 Research
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Neuroinflammation and Neurodegeneration Mechanisms
- Knee injuries and reconstruction techniques
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Shoulder Injury and Treatment
- Per- and polyfluoroalkyl substances research
- Hormonal and reproductive studies
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2025
Wenzhou Medical University
2022-2025
University of Southern California
2019-2025
Shandong Academy of Agricultural Machinery Sciences
2025
Shanxi Medical University
2014-2024
Southern California University for Professional Studies
2022-2024
Harbin Medical University
2002-2024
Air Force Medical University
2019-2024
Second Hospital of Shanxi Medical University
2011-2024
Wuhan Sports University
2024
Abstract Background Cellular senescence, a hallmark of aging, has been implicated in Alzheimer’s disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role cholesterol homeostasis, and expression trafficking altered APOE4 AD models. However, the ABCA1 senescence associated with remains unclear. Methods We examined association between...
Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and prevention intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk tumor formation, low engraftment rates, as well storage transportation logistics. While attempts been to curb these issues, there remains a need for simple effective solutions. A growing body evidence supports theory that delivering media, conditioned with mesenchymal stem cells,...
The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). ApoE protein aggregation plays a central role in AD pathology, including accumulation of β-amyloid (Aβ). Lipid-poor ApoE4 prone to aggregate and lipidating protects it from aggregation. mechanisms regulating vivo are surprisingly not known. lipidation controlled by activity ATP binding cassette A1 (ABCA1). ABCA1 recycling degradation regulated ADP-ribosylation 6 (ARF6). We found that promoted...
Ovarian cancer is the most lethal gynecological cancer. In spite of recent advances, clinical outcomes remain poor, urgently needing novel therapeutic approaches. Growing evidence indicates that microRNAs play crucial roles in ovarian carcinogenesis and progression ferroptosis serves as a tumor suppressor. However, molecular mechanisms miRNA-mediated regulation are still largely unknown. present study, we show miR-424-5p negatively regulates by directly targeting ACSL4 cells. Upregulation...
Abstract Introduction Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, there is no direct genetic evidence for the role of Ihh OA, mice with cartilage or other tissue-specific deletion gene die shortly after birth. We evaluated vivo via a Cre-loxP-mediated approach to circumvent early death caused by deficiency. Methods To evaluate OA...
Rutin inhibited amylin aggregation, amylin-induced neurocytotoxicity, and decreased the production of ROS, NO, GSSG, malondialdehyde pro-inflammatory cytokines.
To determine if supplemental intraarticular α2-macroglobulin (α2 M) has a chondroprotective effect in rat model of osteoarthritis (OA).Using Western blotting, mass spectrometry, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry, α2 M was identified as potential therapeutic agent through comparison concentrations serum, synovial fluid (SF), cartilage from normal subjects patients with OA. In cultured chondrocytes, the effects on interleukin-1 (IL-1)-induced catabolic enzymes...
To investigate if decreased histone deacetylase 4 (HDAC4) is associated with human osteoarthritis (OA) cartilage degeneration by releasing HDAC4 inhibition of runt-related transcription factor-2 (Runx2) resulting in increase OA degeneration-related genes.The mRNA and protein levels HDAC4, Runx2, matrix metalloproteinase (MMP)-13, Indian hedgehog (Ihh) type X collagen were detected performing real-time PCR (RT-PCR), western blotting immunohistochemistry on specimens from normal cartilage....
Abstract Background Apolipoprotein E4 ( APOE4 ) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but mechanisms for this association are not clear. The activation calcium-dependent cytosolic phospholipase A 2 (cPLA2) involved in inflammatory signaling elevated within plaques AD brains. relation between genotype cPLA2 activity known. Methods Mouse primary astrocytes, mouse human brain samples differing by APOE genotypes...
Abstract Background Chronic neuroinflammation is one of the hallmarks late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying apolipoprotein ε4 ( APOE4 ) allele has been associated with an accentuated response to brain inflammation and increases risk AD progression. Among signaling pathways, aberrant eicosanoid activation plays a prominent role in neurodegeneration. Methods Using brains from Religious Order Study (ROS), this study compared measures lipidome older persons...
Background: Although patients with an anterior cruciate ligament (ACL) injury have a high risk of developing posttraumatic osteoarthritis (PTOA), the role meniscus hypertrophy and mineralization in PTOA after ACL remains unknown. Purpose/Hypothesis: The purpose this study was to determine if menisci respond abnormal loading results calcification. hypotheses were that (1) mechanical induces mineralization, which correlates articular cartilage damage vivo, (2) on bovine explants overexpression...
Abstract Histone deacetylase 6 (HDAC6), a member of the HDAC family, has been identified as potential therapeutic target for tumor therapy, but function and underlying mechanisms HDAC6 in colon cancer are incompletely characterized. Our study showed that infiltration ratio M2 macrophages was increased tissues with high expression. Similarly, knockdown cells inhibited cocultured macrophage polarization vitro. Analysis antibody chip revealed promoted sIL-6R release to enhance polarization....