A5026491390- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- Pluripotent Stem Cells Research
- Cytokine Signaling Pathways and Interactions
- Spine and Intervertebral Disc Pathology
- Bone health and treatments
- interferon and immune responses
- Immune Response and Inflammation
- Exercise and Physiological Responses
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Natural product bioactivities and synthesis
- Musculoskeletal pain and rehabilitation
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Protease and Inhibitor Mechanisms
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Bone and Dental Protein Studies
- Flavonoids in Medical Research
- NF-κB Signaling Pathways
- Climate Change and Health Impacts
- Ferroptosis and cancer prognosis
- Biochemical effects in animals
Shanghai University of Traditional Chinese Medicine
2012-2025
Yueyang Hospital
2020-2022
Shuguang Hospital
2013-2018
Shanghai University
2011-2016
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2010-2016
Zhejiang Chinese Medical University
2015
Hunan Academy of Traditional Chinese Medicine
2012
Louisiana State University
2004
Aims: The purpose of this study was to investigate how Osthole affects glioma cell proliferation, apoptosis, invasion and migration. Methods: Rat cells were treated with different concentrations (0 µM, 25 50 100 µM). Cell proliferation assessed by measuring PCNA expression CCK8 assay at time points. Apoptosis evaluated the pro-apoptotic protein including Bax, Bcl2, PARP, cleaved Caspase3, anti-apoptotic Survivin. migration using methods. Signaling pathways such as PI3K/Akt MAPK, which are...
Background: Although patients with an anterior cruciate ligament (ACL) injury have a high risk of developing posttraumatic osteoarthritis (PTOA), the role meniscus hypertrophy and mineralization in PTOA after ACL remains unknown. Purpose/Hypothesis: The purpose this study was to determine if menisci respond abnormal loading results calcification. hypotheses were that (1) mechanical induces mineralization, which correlates articular cartilage damage vivo, (2) on bovine explants overexpression...
Ischemic stroke, a serious neurological disease, is associated with cell death, axonal and dendritic plasticity, other activities. Anti-inflammatory, anti-apoptotic, promote synaptic plasticity are critical therapeutic targets after ischemic stroke. Fibroblast growth factor-2 (FGF2), which involved in the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/CAMP response element (CRE)-binding protein (CREB) pathway, has been shown to facilitate plasticity. Salidroside (Sal) reported...
Background/Aims: Bone marrow-derived mesenchymal stem cells (MSCs) are responsible for new bone formation during adulthood. Accumulating evidences showed that Osthole promotes the osteogenic differentiation in primary osteoblasts. The aim of this study was to investigate whether exhibits a potential stimulate MSCs and underlying mechanism. Methods: were treated with gradient concentration (6.25 µM, 12.5 25 µM). Cell proliferation assessed by western blotting proliferating cell nuclear...
To investigate the characteristics of Vitamin D (VitD) and bone metabolism in patients with knee osteoarthritis (KOA) concurrent osteoporosis (OP). A retrospective analysis was performed on 240 who were admitted to orthopedics department between March 2019 2024. Patients stratified into four distinct groups according their respective disease categories.There 90 simple KOA group, comprising 13 males 77 females, age ranged from 50 91 years old an average (68.48±8.96) old. There OP 7 83 52 88...
Several senescence biomarkers were observed to investigate cell in degenerative intervertebral lumbar discs of foreleg-amputated rats.To determine if is accelerated disc cells an upright-rat model.Cellular was human and sand rat (IVD) cells. Repeated use upright posture by rats contributed changes. No convincing evidence the foreleg amputated rat.The forelimbs 20 at 1 month age such that they maintained stance; housed custom-made cages. Nonamputated rats, also age, kept regular cages served...
Background/Aims: Cartilage destruction is thought to be the major mediator of osteoarthritis. Recent studies suggest that inhibition subchrondral bone loss by anti-osteoporosis (OP) drug can protect cartilige erosion. Osthole, as a promising agent for treating osteoporosis, may show potential in The purpose this study was investigate whether Osthole affects proliferation and catabolism rat chondrocytes, degeneration cartilage explants. Methods: Rat chondrocytes were treated with (0 μM, 6.25...
Most chronic low back pain is the result of degeneration lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly able to relieve pain, suppress inflammation, and treat osteoarthritis it has protective effect on cartilage chondrocytes. Therefore, we asked whether ligustrazine could reduce disc degeneration. To determine degeneration, applied a rat model. The rats was induced by prolonged upright posture. We found that pretreatment with for 1 month recovered...
Tooth eruption requires alveolar bone resorption and formation, both of which appear to be regulated by the dental follicle. Osteoclastogenesis needed for this appears occur as a result reduction in expression osteoprotegerin ( OPG ) gene follicle at specific time. This is mediated vitro cells colony‐stimulating factor‐1 (CSF‐1) parathyroid hormone‐related protein (PTHrP). Using enzyme‐linked immunosorbent assays immunoblotting, study shows that after incubation either CSF‐1 or PTHrP also...
Manipulation under anesthesia (MUA) is often used for frozen shoulder treatment, but controversy still exists regarding MUA compared with conservative treatment. This research was conducted to compare the outcome between and celecoxib (CLX) in secondary shoulder. Patients were randomized into two groups, an plus exercise (EX) group a CLX EX group. Clinical outcomes documented at baseline 1 day, 2, 4, 12 weeks after intervention, including Constant-Murley Score (CMS) function, Pain Rating...
Patients with knee osteoarthritis (KOA) often complain about clinical symptoms affected by weather-related factors. The purpose of the present study was to use cross-sectional analysis determine whether weather sensitivity associated symptoms, as well structure abnormalities, in KOA patients. Data from 80 participants were obtained Feng Hans Shi Effects on OA (FHS) study, an cohort initiated China 2015. each participant determined a self-reported questionnaire. following measurements used...
To study role of TLR4/NF-κB pathway for early change synovial membrane in knee osteoarthritis rats.Eighteen male SD rats weighted (200±20) g were randomly divided into 2 groups, namely control and model group, 9 each group. Knee OA group was established by using modified Hulth method Control not treated. Synovial tissue serum extracted at 4 21 d after operation. Expression CD14, TLR4, IL-1β, TNF-α, ADAMTS-4, MMP-13 detected real-time PCR respectively. NF-κB p65 protein Western-blot;...
To date, it remains poorly understood whether astrocytes can be easily reprogrammed into neurons. Mash1 and Brn2 have been previously shown to cooperate reprogram fibroblasts In this study, we examined from 2-month-old Sprague-Dawley rats, found that was expressed, but not detectable. Thus, hypothesized alone could used We transfected a recombinant MSCV-MASH1 plasmid for 72 hours, saw all cells expressed Mash1. One week later, observed the changes in morphology of astrocytes, which showed...