A5101822417- Bone Metabolism and Diseases
- Temporomandibular Joint Disorders
- Dental Implant Techniques and Outcomes
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Orthodontics and Dentofacial Orthopedics
- Bone Tumor Diagnosis and Treatments
- Cell Adhesion Molecules Research
- Dental materials and restorations
- Oral and Maxillofacial Pathology
- Inflammatory mediators and NSAID effects
- Periodontal Regeneration and Treatments
- Head and Neck Surgical Oncology
- Orthopaedic implants and arthroplasty
- Voice and Speech Disorders
- Electrospun Nanofibers in Biomedical Applications
- Oral microbiology and periodontitis research
- Facial Nerve Paralysis Treatment and Research
- Medical and Biological Sciences
- Total Knee Arthroplasty Outcomes
- Enhanced Oil Recovery Techniques
- Anatomy and Medical Technology
- Bone and Dental Protein Studies
- Streptococcal Infections and Treatments
Shanghai Jiao Tong University
2016-2025
Changzhou University
2025
Renji Hospital
2025
Children's Hospital of Fudan University
2024
Shanghai Ninth People's Hospital
2015-2024
Shanghai Stomatological Hospital
2023-2024
National Clinical Research
2023-2024
Shandong University
2022-2024
National Clinical Research Center for Digestive Diseases
2023
Photochemistry Center
2020
Abstract Orthopedic prostheses are the ultimate therapeutic solution for various end‐stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO 2 ) nanotube drug delivery system loaded cinnamaldehyde surface modification of implants, is constructed. These specially designed dual‐layer TiO nanotubes enhance material reactivity provide an extensive...
Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of reconstruction. However, there still urgent need to design a new TMJ because no commercially available appropriate for the clinical application on Chinese population. This study was introduced prospectively confirm safety effectiveness with customized 3D printing additive fabrication in application.Patients unilateral end-stage osteoarthrosis were recruited this from Nov 2016 Mar 2017. Computed tomography...
Rationale: Inflammatory macrophages and osteoclasts (OCs) play critical roles in joint inflammation, which feature the excessive production of reactive oxygen species (ROS), resulting synovial inflammation bone erosion.Scavenging ROS, especially by modulating mitochondrial metabolic activity, could be a desirable strategy for management inflammatory joints.This study aimed to develop mitochondria-targeted supramolecular drug delivery system with exogenous endogenous ROS-scavenging activities...
Abstract Background Previous research has revealed that the 18 glycoside hydrolase gene family (GH18) member Chitinase 3-like 1 (Chi3l1) can regulate osteoclast differentiation and bone resorption. However, its downstream receptors molecular mechanisms during osteoclastogenesis have yet to be elucidated. Methods Initially, we conducted a comprehensive investigation evaluate effects of recombinant Chi3l1 protein or siRNA on RANKL-induced MAPK/AKT signaling pathways. Moreover, used...
Abstract Nanoparticles exhibit significant potential in modulating oil‐water interfacial tension, altering rock wettability, and optimizing fluid flow for enhanced oil recovery. This study employs MD simulations to investigate the effects of surface‐modified nanoparticles (pure‐NP, alkyl‐NP, carboxylate‐NP) on layer thickness, displacement energy. Results reveal that alkyl‐NP reduces tension most effectively (32.57 mN·m⁻¹), followed by carboxylate‐NP (38.64 mN·m⁻¹) pure‐NP (45.02 mN·m⁻¹)....
Objective: To explore the relationship between sleep quality and risk of all-cause mortality based on a large-scale prospective cohort elderly people aged 60 above in Shanghai community. Methods: In 2019, 17 948 community were recruited to participate Community Elderly Cohort. Baseline information members was collected through face-to-face questionnaires, during most recent month using Pittsburgh Sleep Quality Index (PSQI) scale. The association analyzed multifactorial Cox regression models....
Kaempferide (KF) is an O-methylated flavonol, a natural plant extract, which often found in Kaempferia galanga. It has variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties. In this study, we aimed to investigate whether KF effectively inhibits titanium particle induced calvarial bone loss via down regulation the JNK signaling pathway. mice with osteolysis, Low dose mildly reduced resorption pits while high group, fewer...
As a degenerative disease in joints, temporomandibular joint osteoarthritis (TMJOA) is characterized by progressive cartilage degradation, subchondral bone remodeling, and chronic synovitis, severely undermining functions quality of life patients. NADPH oxidase 4 (NOX4) contributes to reactive oxygen species (ROS) production inflammatory pathway activation osteoarthritis, which has attracted increasing attention research recent years. GLX351322 (GLX), novel NOX4 inhibitor, exerts protective...
Abstract A series of osteolytic bone diseases are usually related to excessive resorption and osteoclast formation. Thus, agents or drugs which can target development attenuate loss potentially considerable in preventing treating lytic diseases. In recent years, many studies have reported that Notch signaling has substantial impacts on the process differentiation, maturation, destruction. present study, we showed LY411575, a γ‐secretase inhibitor, could potently suppress osteoclast‐specific...
Abstract Considering the high rate of osteoclast‐related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well function dose‐dependently. CS suppressed osteoclast‐specific genes expression during osteoclastogenesis. Furthermore, found attenuated receptor activator nuclear factor kappa B ligand (RANKL)‐mediated mitogen‐activated protein kinase (MAPK) pathway...
Inflammatory macrophages within the synovium play a pivotal role in progression of arthritis inflammation. Effective drug therapy targeting inflammatory has long been goal for clinicians and researchers. The standard approach treating osteoarthritis (OA) involves systemic treatment local injection. However, high incidence side effects associated with long-term administration increases risk complications patients. Additionally, rapid clearance joint cavity poses biological barrier to...
Abstract The purpose of this study was to confirm the 5-year efficiency temporomandibular joint (TMJ) anchorage, using clinical evaluation and magnetic resonance imaging (MRI). We also studied influence disc length position on postoperative condylar height. Sixty-one patients (76 joints) undergoing TMJ anchorage were followed up for >5 years. Visual analogue scale (VAS) score maximum mouth-opening pre-and postsurgery analysed patient satisfaction recorded. Disc length, condyle height pre-...
To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently combination, for repair defects Beagle dogs. Six months after extraction mandibular premolars and first molars from three beagle dogs, inserted implants assigned into 3 groups covered with following combinations: Group A: Implant + Bio-Oss Ti-mesh, B: Bio-Gide, C: Ti-mesh Bio-Gide. At 6 months, micro-CT...
Abstract This study aimed to establish an effective prognostic nomogram for predicting the probability of postoperative bone remodeling patients with anterior disc displacement without reduction (ADDWoR). The was based on a retrospective underwent surgical approaches ADDWoR at Shanghai Ninth People’s Hospital, Jiao Tong University from January, 2007 2017. A multivariate logistic regression analysis used develop variables suitable estimation model. predictive accuracy and discriminative...
The application of a coordination container in biomedicine is hindered by single binding domains and unsatisfactory biostability biocompatibility. Herein, we designed sulfonylcalix[4]arene-based decahexanuclear zinc(II) employing flexible tetracarboxylate ligand as linker utilized it novel drug delivery system. consisting one endo four exo cavities provides multiple for efficient encapsulation molecules clearly revealed systematic host–guest studies using NMR techniques 1H titration...