A5072916081- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Chemokine receptors and signaling
- Olfactory and Sensory Function Studies
- Dental Radiography and Imaging
- Cancer, Hypoxia, and Metabolism
- Dental Anxiety and Anesthesia Techniques
- Circular RNAs in diseases
- Neonatal Health and Biochemistry
- Bone and Dental Protein Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- Anesthesia and Sedative Agents
- Oral Health Pathology and Treatment
- melanin and skin pigmentation
- Bone Tumor Diagnosis and Treatments
- Obstructive Sleep Apnea Research
- Temporomandibular Joint Disorders
- Endodontics and Root Canal Treatments
- Oral and Maxillofacial Pathology
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
Shandong University
2014-2024
Beijing University of Agriculture
2014
Second Military Medical University
2013
Stomatology Hospital
2013
Westat (United States)
2009
Children's Hospital of Philadelphia
2009
Qilu Hospital of Shandong University
2006
Quanta Computer (China)
2005
Abstract Background Due to the lack of research on pathological mechanism temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in clinic. In recent years, microRNAs (miRs) have been demonstrated play an important role pathogenesis (OA) by regulating a variety target genes, and latest evidence shows that miR-21-5p is specifically overexpressed OA. The purpose this project was clarify whether can regulate TMJOA process targeting Spry1. Methods induced...
To examine the possible involvement and regulatory mechanisms of extracellular signal-regulated kinase (ERK) pathway in temporomandibular joint (TMJ) rats subjected to chronic sleep deprivation (CSD).Rats were CSD using modified multiple platform method (MMPM). The serum levels corticosterone (CORT) adrenocorticotropic hormone (ACTH) tested histomorphology ultrastructure TMJ observed. ERK phospho-ERK (p-ERK) expression detected by Western blot analysis, MMP-1, MMP-3, MMP-13 real-time...
The main causes of cartilage destruction during temporomandibular joint osteoarthritis (TMJOA) are extracellular matrix degradation and angiogenesis, accompanied by an increased level matrix-degrading enzymes proangiogenic factors. Interleukin 6 signal-regulated kinase (ERK) signaling pathways may play a critical role in these two processes simultaneously, but researchers have not clearly determined the mechanism. We hypothesized that estrogen-related receptor γ (ERRγ) is involved both...
Abstract Objectives The pathogenesis of temporomandibular joint osteoarthritis (TMJOA) remains not fully understood. Our previous studies demonstrated that miR‐21‐5p may participate in the TMJOA development and interaction between circRNA‐ACAP2 (CircACAP2) miR‐21‐5p. present study aimed to explore biological functions regulatory mechanisms CircACAP2 TMJOA. Materials Methods differential expression pattern OA normal tissues or cells was detected. experiments were performed chondrocytes by...
The purpose of this study was to elucidate the role circadian gene Bmal1 in human cartilage and its crosstalk with MAPK/ERK signaling pathway temporomandibular joint osteoarthritis (TMJ-OA). We verified periodical variation then established a modified multiple platform method (MMPM) induce rhythm disturbance leading TMJ-OA. IL-6, p-ERK, mRNA protein expression levels were assessed by real-time RT-PCR immunohistochemistry. Chondrocytes treated an ERK inhibitor (U0126), siRNA plasmid targeting...
Aims The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). Methods TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) a unilateral anterior crossbite (UAC) procedure. Mouse tissues exhibited histopathological changes, as assessed by: Safranin O, toluidine blue, immunohistochemistry staining; western blotting (WB); quantitative real-time polymerase chain...
Circular RNAs (circRNAs) contain microRNA (miRNA)-specific binding sites and can function as miRNA sponges to regulate gene expression by suppressing the inhibitory effect of miRNAs on their target genes. MiR-21-5p has been reported be involved in development head neck squamous cell carcinoma (HNSCC) plays an important role activation epithelial-mesenchymal transition (EMT). However, upstream regulatory mechanism downstream targets miR-21-5p tumor cells remain unknown. CircRNA_ACAP2 inhibits...
// Yabing Dong 1, 2, * , Gaoyi Wu 3, Ting Zhu Hongyu Chen 2 Yong Guoxiong 3 Fabin Han 4 Huaqiang Zhao 1 School of Stomatology, Shandong University, Wen Hua Xi Lu, Jinan City 250012, Province, China Provincial Key Laboratory Oral Tissue Regeneration, Department Military General Hospital, Shi Fan 250031, Center for Stem Cells and Regenerative Medicine, The Affiliated Liaocheng Taishan Medical 252000, These authors contributed equally to this work Correspondence to: Zhao, email:...
The aim of this study was to explore the mechanisms Hyperbaric oxygen (HBO) protective on interleukin-1β (IL-1β) induced rat's mandibular condylar chondrocytes. Chondrocytes were exposure after inflammatory by IL-1β. After that, expression p-JNK and c-Jun increased significantly, while Sox-9 decreased Immunofluorescence results showed that p-c-Jun COL2 in chondrocytes treated with IL-1β selective JNK inhibitor. might plays similar roles JNK-specific inhibitor SP600125, inducing increase...