A5101933574- Tendon Structure and Treatment
- Diet and metabolism studies
- Knee injuries and reconstruction techniques
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- HER2/EGFR in Cancer Research
- Dietary Effects on Health
- Osteoarthritis Treatment and Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Shoulder Injury and Treatment
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Chronic Kidney Disease and Diabetes
- Head and Neck Anomalies
- Gallbladder and Bile Duct Disorders
- Trauma Management and Diagnosis
- Potassium and Related Disorders
- Aortic aneurysm repair treatments
- Obstructive Sleep Apnea Research
- Parathyroid Disorders and Treatments
- Extracellular vesicles in disease
- Clinical Nutrition and Gastroenterology
- Plant Surface Properties and Treatments
- Antioxidant Activity and Oxidative Stress
The First People's Hospital of Jiangxia District
2025
Huazhong University of Science and Technology
2020-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Fujian Agriculture and Forestry University
2024
University of Science and Technology of China
2024
Anhui Medical University
2024
Children's Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
China International Science and Technology Cooperation
2023
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage renal (ESRD) worldwide. SGLT2 inhibitors are clinically effective in halting DKD progression. However, underlying mechanisms remain unclear. The serum and kidneys mice with were analyzed using liquid chromatography tandem mass spectrometry (LC–MS/MS)-based metabolomic proteomic analyses. Three groups established: placebo-treated littermate db/m mice, db/db EMPA-treated mice. Empagliflozin (EMPA) placebo (10 mg/kg/d)...
Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is commonly used as dietary supplement in treating woman with menopausal irregularity, contains two herbs: Radix Astragali (Huangqi) and Angelicae Sinensis (Danggui). The ratio of DBT should be 5:1 described China 1247 A.D.; however, the rationale this formula has not been given. Here, chemical biological properties DBT, prepared from different ratios drugs, were determined. Significantly, higher amounts Astragali-derived...
Despite our previous study that demonstrates human embryonic stem cells (hESCs) can be used as seed for tendon tissue engineering after stepwise induction, suboptimal regeneration implies a new strategy needs to developed repair. We investigated whether overexpression of the tendon-specific transcription factor scleraxis (SCX) in hESC-derived mesenchymal (hESC-MSCs) together with knitted silk-collagen sponge scaffold could promote regeneration.hESCs were initially differentiated into MSCs...
The increasing prevalence of obesity-related glomerulopathy (ORG) poses a significant threat to public health. Sodium-glucose cotransporter-2 (SGLT2) inhibitors effectively reduce body weight and total fat mass in individuals with obesity halt the progression ORG. However, underlying mechanisms their reno-protective effects ORG remain unclear. We established high-fat diet-induced model using C57BL/6J mice, which were divided into three groups: normal chow diet (NCD group), (HFD) mice treated...
Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain the short-term but often leads to osteoarthritis (OA) long-term. Here, this study aimed identify and characterize a novel population of meniscus-derived stem cells (MeSCs) develop new strategy articular cartilage protection by intra-articular injection these cells. The "stemness" immune properties MeSCs were investigated vitro, while efficacy for...
Abstract Background Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular neurological manifestations poor wound healing. Adhering to Mediterranean Diet (MED) generally considered an effective intervention in individuals at risk for type mellitus (T2DM). However, little known about its effect respect the different specific T2DM. This prompted us explore MED on three most significant microvascular complications T2DM: diabetic retinopathy (DR),...
Abstract Calcification of soft tissues, such as heart valves and tendons, is a common clinical problem with limited therapeutics. Tissue specific stem/progenitor cells proliferate to repopulate injured tissues. But some them become divergent the direction ossification in local pathological microenvironment, thereby representing cellular target for pharmacological approach. We observed that HIF-2alpha (encoded by EPAS1 inclined form) signaling markedly activated within recruited at calcified...
Current surgical management of anterior cruciate ligament (ACL) rupture still remains an intractable challenge in ACL regeneration due to the weak self-healing capability ACL. Inadequate cell numbers and vascularization within articular cavity contribute mainly poor prognosis. This time, we fabricated a new tissue engineering scaffold by adding stem/progenitor (LSPC) sheets our previous knitted silk-collagen sponge scaffold, which overcame these limitations providing sufficient seed cells...
End-stage renal disease (ESRD) patients usually develop extensive and progressive vascular calcification, lots of calcification inhibitors as well procalcifying factors are involved in the process. However, mechanisms ESRD still ill-defined. In present study, we found that plasma exosomes derived from (ESRD-Ex) promoted smooth muscle cells (VSMCs) significantly, while transplant recipients (RTR-Ex) could partially attenuate VSMCs calcification. Moreover, protein concentration ESRD-Ex was...
// Yabing Dong 1, 2, * , Gaoyi Wu 3, Ting Zhu Hongyu Chen 2 Yong Guoxiong 3 Fabin Han 4 Huaqiang Zhao 1 School of Stomatology, Shandong University, Wen Hua Xi Lu, Jinan City 250012, Province, China Provincial Key Laboratory Oral Tissue Regeneration, Department Military General Hospital, Shi Fan 250031, Center for Stem Cells and Regenerative Medicine, The Affiliated Liaocheng Taishan Medical 252000, These authors contributed equally to this work Correspondence to: Zhao, email:...
Ultrasonography (renamed from the Journal of Korean Society Ultrasound in Medicine January 2014), official English-language journal (KSUM), is an international peer-reviewed academic dedicated to practice, research, technology, and education dealing with medical ultrasound, Aims Scope:Ultrasonography ultrasound.It published four times per year: 1, April July October 1. Original articles, topical reviews, pictorial essays, notable case reports are covering state-of-the-art content. also...
Although cell transplantation therapy can effectively promote functional tendon repair, occasional ectopic ossification during regeneration undermines its efficacy. The effect of transplanted types on has not yet been systematically evaluated. This study compared the rate repair upon with mouse fetal fibroblasts (FFs) and their adult counterparts (adult [AFs]). Alkaline phosphatase (ALP) staining, immunofluorescence, gene expression analysis were used to compare spontaneous osteogenic...
Identification of cholangiocarcinoma (CCA) associated with hepatolithiasis (HL) is difficult. There no effective method to discriminate CCA HL (HL-CCA) from currently.To explore the value clinical data, ultrasonic characteristics and miRNA expression level in identification HL-CCA.Thirty-one patients HL-CCA Huazhong University Science Technology Union Shenzhen Hospital were enrolled observation group, while 40 alone included control group. The characteristics, two groups recorded analyzed...
The objective of this study was to investigate the clinical characteristics and analysis related factors associated with early death in newly diagnosed patients acute promyelocytic leukemia (APL). This retrospective included who visited our hospital between January 2010 August 2022 were APL for first time. We analyzed their laboratory death. A total 269 a primary diagnosis collected. male female ratio 6:5, median age 42 years (range 7–80). Among initial diagnosis, there 34 deaths, resulting...
Duck circovirus (DuCV) infections commonly induce immunosuppression and secondary in ducks, resulting significant economic losses the duck breeding industry. Currently, effective vaccines treatments for DuCV have been lacking. Therefore, rapid, specific, sensitive detection methods are crucial preventing controlling DuCV. A lateral flow strip (LFS) method was developed using recombinase polymerase amplification (RPA) clustered regularly interspaced short palindromic repeats...