A5078947486- Gastroesophageal reflux and treatments
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Nutrition and Health in Aging
- Helicobacter pylori-related gastroenterology studies
- Neonatal Respiratory Health Research
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Neonatal and Maternal Infections
- Cancer Risks and Factors
- Inflammatory Bowel Disease
- Cytomegalovirus and herpesvirus research
- Pediatric health and respiratory diseases
- Esophageal and GI Pathology
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Gallbladder and Bile Duct Disorders
- Gestational Diabetes Research and Management
- Bone health and osteoporosis research
- Central Venous Catheters and Hemodialysis
- Obesity, Physical Activity, Diet
- Pancreatitis Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Esophageal Cancer Research and Treatment
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Jiujiang First People's Hospital
2023
Soochow University
2012-2022
Jiangsu University
2022
First People's Hospital of Kunshan
2022
Sichuan University
2009-2021
West China Second University Hospital of Sichuan University
2009-2020
Second Affiliated Hospital of Zhengzhou University
2018-2020
Yueqing People's Hospital
2012
Proton pump inhibitors (PPIs) have a major impact on gut microbiome and immune function, which in turn, may increase the risk of inflammatory bowel disease (IBD). Our aim this study was to evaluate PPI use subsequent IBD subtypes (ie, Crohn's ulcerative colitis).This pooled analysis Nurses' Health Study (NHS, n = 82,869), NHS II (n 95,141), UK Biobank 469,397). We included participants with information personal PPIs free or cancer at baseline. evaluated hazard ratios 95% confidence intervals...
Abstract Objective The association between Metabolic Syndrome (MetS), its components, and the risk of osteoarthritis (OA) has been a topic conflicting evidence in different studies. aim this present study is to investigate MetS, OA using data from UK Biobank. Methods A prospective cohort was conducted Biobank assess related MetS. MetS defined according criteria set by International Diabetes Federation (IDF). Additionally, lifestyle factors, medications, inflammatory marker C-reactive protein...
The association between the regular use of proton pump inhibitors (PPIs) and risk type 2 diabetes remains unclear, although a recent randomised controlled trial showed trend towards increased risk. This study was undertaken to evaluate PPIs diabetes.This is prospective analysis 204 689 participants free in Nurses' Health Study (NHS), NHS II Professionals Follow-up (HPFS). Type confirmed using American Diabetes Association (ADA) diagnostic criteria. We evaluated hazard ratios (HRs) adjusting...
Abstract Proton pump inhibitors (PPIs) are commonly used for gastric acid-related disorders, but their safety profile and risk stratification high-burden diseases need further investigation. Analyzing over 2 million participants from five prospective cohorts the US, UK, China, we found that PPI use correlated with increased of 15 leading global diseases, such as ischemic heart disease, diabetes, respiratory infections, chronic kidney disease. These associations showed dose-response...
Abstract Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, the potential mechanisms underlying associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis based on UK Biobank dataset. MetS was defined according International Diabetes Federation criteria identified through linkage registries (median follow‐up time: 6.6 years). We...
Although excess adiposity has been linked with various cancers, association between body composition and some cancers remains unclear, like lung prostate cancers. We investigated associations of risk overall cancer major site-specific in a prospective cohort 454 079 cancer-free participants from UK-Biobank. Body was measured bioimpedance analysis. evaluated hazard ratio (HR) 95% confidence interval (CI) multivariate Cox linear nonlinear models men women separately. identified 27 794 over 7.6...
Abstract Background Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular neurological manifestations poor wound healing. Adhering to Mediterranean Diet (MED) generally considered an effective intervention in individuals at risk for type mellitus (T2DM). However, little known about its effect respect the different specific T2DM. This prompted us explore MED on three most significant microvascular complications T2DM: diabetic retinopathy (DR),...
ABSTRACT The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such body mass index, which are unable to discriminate between lean and fat mass. We undertook this study examine composition subsequent cancer. This prospective analysis participants free from the UK Biobank. measured baseline with electrical bioimpedance confirmed diagnosis through linkage death registries. evaluated hazard ratios (HRs) confidence interval (CIs)...
Objective Gestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific diseases is lacking, and findings potential impact type 2 are not consistent. This study aimed explore between risks Methods Data were from 12,025 women (≥20 years) who had delivered at least one live birth in National Health Nutrition Examination Survey, 2007–2018. history including coronary heart disease (CHD), failure...
Abstract Background Paracetamol induces hepatotoxicity and subsequent liver injury, which may increase the risk of cancer, but epidemiological evidence remains unclear. We conducted this study to evaluate association between paracetamol use cancer. Methods This prospective included 464,244 participants free cancer diagnosis from UK Biobank. Incident was identified through linkage death registries National Health Service Central Register using International Classification Diseases (ICD)-10...
Abstract Background Limited epidemiological evidence exists regarding the role of healthy eating patterns in reducing risk Crohn’s disease (CD) and ulcerative colitis (UC). This study aimed to investigate association between adherence four established subsequent CD or UC risk, further examined whether these associations are linked anti-inflammatory mechanisms. Methods We conducted a prospective cohort 197,391 participants from UK Biobank who completed at least one dietary questionnaire were...
The obesity paradox is common among older adults at risk for various diseases. Although this has also been observed in the association between and osteoporosis, available evidence remains controversial. This study aimed to investigate OP an population. A cross-sectional prospective was conducted using data from 177,734 participants UK Biobank. of body mass index (BMI), waist circumference (WC), fat percentage with BMD examined Spearman correlation analysis baseline data. Cox proportional...
<title>Abstract</title> <bold>Background</bold> Mediterranean Diet (MED) is recommended for managing patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). However, the potential metabolic changes involved in this relationship remain unclear. This study aims to investigate how biomarkers mediate association between MED adherence and liver-related events (LRE) mortality MASLD.<bold>Methods</bold> We performed a prospective analysis using UK Biobank data, including...
Abstract Background Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but extent which increased genetic risk can be mitigated by adhering a healthy remains unclear. We aimed investigate association combined with cancer within groups. Methods conducted prospective study 375 998 unrelated participants European ancestry genotype data free from UK biobank. generated polygenic score (PRS) using 16 single nucleotide polymorphisms based on body weight, smoking...
Little is known on the gender-specific effect and potential role of non-linear associations between metabolic syndrome (MetS) components liver cancer risk. We evaluated these based UK Biobank cohort.We included 474,929 individuals without previous cohort. Gender-specific hazard ratios (HRs) 95% confidence interval (CIs) were calculated by Cox proportional hazards regression, adjusting for confounders. Non-linear individual MetS assessed restricted cubic spline method.Over a median follow-up...
INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status longstanding diseases, regular PPIs not associated an increased risk all-cause due to neoplasms, circulatory system respiratory digestive external causes, other causes....
Cross-sectional studies have suggested a potential association between living alone and hypertension risk, but longitudinal evidence remains limited. We aimed to investigate the correlation alone, alterations in arrangements, risk among older adults utilizing population-based design.The study included 8 782 (≥65 years) without from Chinese Longitudinal Healthy Longevity Survey. Participants were surveyed during 2008 2011/2012 waves subsequently followed up next wave. Hypertension was defined...
Abstract Background Waist circumference (WC), calf (CC), and body mass index (BMI) have been independently linked to mortality. However, it's not yet clear how the waist-calf ratio (WCR) relates This study aims investigate relationship between WCR, WC, CC, BMI with all-cause cause-specific mortality in older adults. Methods In 2014 Chinese Longitudinal Healthy Longevity Survey, 4627 participants aged 65 years were included, they subsequently followed up 2018. Cox proportional hazards models...
Abstract Several observational studies have suggested that proton‐pump inhibitor (PPI) use might increase diabetes risk, but the mechanism remains unclear. This study aimed to investigate effects of PPI on gut microbiota and bile acids (BAs) profiles, explore whether these changes could mediate association PPIs with fasting blood glucose (FBG) levels insulin resistance (IR) in Chinese population. A cross‐sectional was conducted Shenzhen, China, from April August 2021, enrolled 200 eligible...