A5019378507- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Total Knee Arthroplasty Outcomes
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Coal Properties and Utilization
- Methane Hydrates and Related Phenomena
- Hydrocarbon exploration and reservoir analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Orthopedic Infections and Treatments
- Spinal Fractures and Fixation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Functional Brain Connectivity Studies
- Dental Implant Techniques and Outcomes
- Cellular and Composite Structures
- Ferroptosis and cancer prognosis
- Hip disorders and treatments
- Soft tissue tumor case studies
- Landfill Environmental Impact Studies
Second Hospital of Hebei Medical University
2022-2025
Hebei Medical University
2021-2025
Nankai University
2025
Second Affiliated Hospital of Jilin University
2019-2024
National Clinical Research Center for Digestive Diseases
2023-2024
Peking University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
China University of Geosciences (Beijing)
2021-2023
Tongji University
2022-2023
Beijing Friendship Hospital
2015-2023
Abstract Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-ex) have become a hopeful substitute for whole-cell therapy due to their minimal immunogenicity and tumorigenicity. The present study aimed investigate the hypothesis that hUCMSC-ex can alleviate excessive inflammation resulting intracerebral hemorrhage (ICH) facilitate rehabilitation of nervous system in rats. In vivo, hemorrhagic stroke was induced by injecting collagenase IV into striatum rats using...
Solid titanium alloys are extensively employed in orthopedic applications due to their reliable mechanical strength, but the stress shielding phenomenon caused by its high elastic modulus and disadvantage of lack bone integration may lead clinical complications. The design porous structure is a feasible approach reduce promote vascular ingrowth. This paper reviewed application current challenges solid implants orthopedics. To address drawbacks explore that can effectively integrate with...
Abstract Background Due to the lack of research on pathological mechanism temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in clinic. In recent years, microRNAs (miRs) have been demonstrated play an important role pathogenesis (OA) by regulating a variety target genes, and latest evidence shows that miR-21-5p is specifically overexpressed OA. The purpose this project was clarify whether can regulate TMJOA process targeting Spry1. Methods induced...
In orthopedic implant development, incorporating a porous structure into implants can reduce the elastic modulus to prevent stress shielding but may compromise yield strength, risking prosthesis fracture. Bamboo's natural structure, with its exceptional strength-to-weight ratio, serves as inspiration. This study explores biomimicry using bamboo-inspired scaffolds (BISs) resembling cortical bone, assessing their mechanical properties and fluid characteristics. The BIS consists of two 2D units...
Circular RNAs (circRNAs) exert critical functions in tumorigenesis and tumor development, but whether how circRNAs contribute to laryngeal squamous cell carcinoma (LSCC) is unclear. In this study, we explored the function mechanisms of circRNA_100290 LSCC. Tissue samples were obtained from 40 patients with The expression other targets was measured through quantitative reverse transcription-polymerase chain reaction western blot analysis. Cell proliferation, colony-forming ability, apoptosis...
Background and objective: The osteoporotic vertebral compression fracture (OVCF) has an incidence of 7.8/1000 person-years at 55-65 years. At 75 years or older, the increases to 19.6/1000 in females 5.2-9.3/1000 males. To solve this problem, percutaneous vertebroplasty (PVP) was developed recent been widely used clinical practice treat OVCF. Are effects unilateral (UPVP) bilateral (BPVP) same? purpose study compare biomechanical differences between UPVP BPVP using finite element analysis....
Exosome-based therapeutics have garnered significant attention for intracerebral hemorrhage (ICH) treatment due to their capacity regulate metabolic dysregulation, restore cellular homeostasis, and modulate the injury microenvironment via bioactive cargoes such as microRNAs proteins. However, rapid systemic clearance enzymatic degradation critically limit therapeutic efficacy. To address this challenge, we engineered a three-dimensional (3D) bioprinted scaffold capable of encapsulating...
Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-ex) have emerged as a promising alternative to whole-cell therapies due their minimal immunogenicity and tumorigenicity. Pentraxin 3 (PTX3) acts an inflammatory marker pattern recognition receptor, playing critical role in promoting tumor progression diseases. Fibrotic scars resulting from cerebral hemorrhage can impair motor sensory functions, leading poor prognosis. This study aimed investigate whether hUCMSC-ex regulate...
The updated classification of odontogenic tumors by the World Health Organization (WHO) has included adenoid ameloblastoma (AA) as a distinct entity. However, distinguishing between AA and dentinogenic ghost cell tumor (DGCT) can still be challenging due to their significant morphologic similarities. In this study, we aimed compare clinicopathologic, immunohistochemical, molecular characteristics DGCT aid in differentiation shed light on pathologic mechanisms. Thirteen cases 14 (15 samples)...
Intracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high incidence, disability rate, and mortality. Epigallocatechin gallate (EGCG), key catechin compound found in green tea, has received increasing attention for its potential neuroprotective therapeutic effects neurological disorders. Studies have indicated that EGCG may influence various signaling pathways molecular targets, including the inhibition of oxidative stress, reduction inflammatory responses,...
Our previous studies have confirmed that α2δ1 has the potential to function as a cancer stem cell marker, and CACNA2D1 is coding gene of α2δ1. But it unclear how microRNAs regulate expression in laryngeal cells. We detected expressions protein, microRNA-107, 40 pairs tissues adjacent normal tissues. Laryngeal squamous carcinoma cells, TU212 TU686, were cultured transfected blank control group, agomiR negative agomiR-107 antagomiR or antagomiR-107 dual-luciferase reporter assay was employed...
In this study, the electromagnetic (EM) performance of rice husk ash (RHA) calcined from was evaluated. Porous RHA with a bulk density 0.4 g cm-3 is mainly composed carbon and silica. The degrees surface melting destruction porous structure increase ashing temperature, while nitrogen atmosphere retards because retention carbon. A temperature 700 oC lower limit for achieving significant melting, whereas 800 in air will destroy conductive network formed by melting. All samples showed low...