A5022278851- Ferroptosis and cancer prognosis
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Cell Image Analysis Techniques
- Spinal Cord Injury Research
- Photodynamic Therapy Research Studies
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- Polyomavirus and related diseases
- Meningioma and schwannoma management
- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Healthcare and Venom Research
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
Hebei Medical University
2015-2024
Second Hospital of Hebei Medical University
2015-2024
Jilin University
2024
Union Hospital
2024
Capital University
2022
Capital Medical University
2022
Handan College
2022
Fifth Tianjin Central Hospital
2022
Abstract Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-ex) have become a hopeful substitute for whole-cell therapy due to their minimal immunogenicity and tumorigenicity. The present study aimed investigate the hypothesis that hUCMSC-ex can alleviate excessive inflammation resulting intracerebral hemorrhage (ICH) facilitate rehabilitation of nervous system in rats. In vivo, hemorrhagic stroke was induced by injecting collagenase IV into striatum rats using...
Intracerebral hemorrhage (ICH) is a common cerebral vascular disease with high incidence, disability, and mortality. Ferroptosis regulated type of iron-dependent, non-apoptotic programmed cell death. There increasing evidence that ferroptosis may lead to neuronal damage mediated by hemorrhagic stroke damage. Salvianolic acid A (SAA) natural bioactive polyphenol compound extracted from salvia miltiorrhiza, which has anti-inflammatory, antioxidant, antifibrosis activities. SAA reported be an...
Controlled generation of cytotoxic reactive oxygen species (ROS) is essential in cancer therapy. Ultrasound (US)-triggered sonodynamic therapy (SDT) has shown considerable ability to trigger
Calcium/calmodulin-dependent protein ID (CAMK1D) is widely expressed in many tissues and involved tumor cell growth. However, its role gliomas has not yet been elucidated. This study aimed to investigate the roles of CAMK1D proliferation, migration, invasion glioma. Through online datasets, Western blot, immunohistochemical analysis, glioma tissue significantly lower expression levels than normal brain (NB) tissues, was positively correlated with WHO classification. Kaplan-Meier survival...
Objective . Human umbilical cord mesenchymal stem cells (hUC-MSCs) potentially differentiate to various types of including neuron-like cells. The natural polyphenol resveratrol benefits patients with many diseases ischemic brain injury. We hypothesize that induces differentiation hUC-MSCs into Methods Flow cytometry was used determine the surface antigens in different stage (P2, P5, and P10). Nestin, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) were detected by...
Objective . The human umbilical cord mesenchymal stem cells (hUMSCs) are characterized with the potential ability to differentiate several types of cells. Edaravone has been demonstrated prevent hUMSCs from oxidative damage, especially its in antioxidative stress. We hypothesized that induces into neuron-like Methods were obtained tissue. differentiation was induced by three different doses: 0.65 mg/ml, 1.31 and 2.62 mg/ml. Flow cytometry used detect cell markers. Protein mRNA levels nestin,...
In the present study, human umbilical cord-derived mesenchymal stem cells (hUMSCs) were investigated for their potential to be induced differentiate in vitro into neuron-like by monosialoteterahexosyl ganglioside (GM1). Mononuclear obtained from cords women with full-term pregnancies whose babies delivered cesarean section cultivated and surface antigen expression profiles monitored. Following amplification, divided 5 groups, of which 4 (groups A-D) treated GM1 at doses 50, 100, 150 200...
Abstract Background ATP7B is a copper-transporting protein that contributes to the chemo-resistance of human cancer cells. It remains unclear what molecular mechanisms behind are in cancer, as well its role pan-cancer studies. Methods Our study evaluated differential expression and paracancerous tissues based on RNA sequencing data from GTEx TCGA. Kaplan–Meier Cox proportional hazards regressions were used estimate prognostic factors associated with ATP7B.The correlations between immune cell...
STEAP3 is a metal reductase located on the plasma membrane close to nucleus and vesicles. Despite numerous studies indicating involvement of in tumor advancement, prognostic value glioma related mechanisms have not been fully investigated.Initially, we examined correlation between expression survival rate various datasets. To assess capability for one-year, three-year, five-year survival, created receiver operating characteristic (ROC) curves nomograms. Additionally, an investigation was...
ACSS3 (acyl-CoA synthetase short-chain family member 3) is found in numerous tissues and linked to tumor cell type development metastasis.
Abstract Background ZFHX4-AS1 is a recently discovered long noncoding RNA, and whether it involved in glioma progression unclear. Results We found that its nearby gene ZFHX4 were highly expressed gliomas through analysis of online databases combined with experimental validation collected tissues cells. In functional experiments, we high expression levels or stimulated the proliferation, invasion migration Furthermore, overexpression silencing resulted same changes levels. Combined rescue...
Abstract Aims: This study aimed to determine the role and correlation of miR-153-5p GAB1 in proliferation, invasion migration malignant meningioma. Background: Meningiomas are most common primary intracranial tumor adults.For meningioma, only effective treatment targeted therapy is excision radiotherapy.However,some meningiomas prone recurring due specific disease sites or an blood vessels nerves, prognosis poor.To discover biomarkers develop therapies, it necessary better understand...